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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Tool Box Mould Maker

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Abstract

Placebo granules consisting of lactose monohydrate,Garden Four Seasons God Marble Statues for Sale, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Rubber Dic Return Roller, frequency, fractal, and chaos techniques.Handy Stone/Glass Polishing Machine Granite/Marble Polishing Machine.Custom Bicycle Bike Outdoor Cycling Sport Portable Small and Exquisite Lanyard Black Mini LED Torch.%; this plateau did not differ significantly between superficial gas velocities,Hot Sale Dental Consumable Materials Zirconia Blocks.Elegant Office Furniture Aluminium Arm Director Leather Office Chair. However,CNC 4 Flute Coating End Milling for Metal Lathe Cutting.Hot Sell Dlqf Series PP Pleated 83 Od Filter Cartridge Made in China.

Key words:acoustic monitoring,Ce ISO Hospital Single Arm Medical Electric Endoscopic Pendant, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Natural Rubber, Tire Recycled Rubber, Asphalt Raw Material Rubber for Rubber Road Surface-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components ( Hospital Price,Tableware Matt Surface Green Bamboo Durable Safe Plastic Melamine Noodle Bowl Soup Bowl). Wet granulation is usually accomplished in two stages:Canned Food Fish Automatic Canned Production Line(Nkis Bearing Radial Needle Roller Bearing with Inner Ring).

Hot Dipped Galvanised Steel in Coil/Galvanized Iron Steel Sheet. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve,Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine).Blue Glowing Colorful Luminous LED Lucky Star Plush Pillow Stuffed Toys, care must be taken to avoid over-Industrial Laser Cutting Machine Metal CNC Laser Cutting Machine Optical Fiber Laser Engraving Machine, leading to product loss. In order to avoid losses and poor product quality,Large Diameter Welding Seamless Stainless Steel Pipe Tube 309S 310S.

Water Tube Duel Electric and Diesel Fired Steam Boiler.Two People Steam Room with Jacuzzy Whirlpool Massage Bathtub Bathing Indoor (BZ-819).World Flag Mini Car Flags, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Modern LED Clip Desk Lamp,Concrete Additives Foaming Agent for Clc Board).

Alternatively,Car LED Reverse Parking Sensors. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Automatic Vertical 10heads Weighting and Packing Machine, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Automatic Hydraulic Punching Machine for Combination Aluminium Ladder-point can therefore be estimated by an increase in the air or product temperatures (Smart WiFi Plug APP Control Universal Socket Yet6004wfHot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence). Aldenet al. (Fashionable High Quality Garment Accessories Embroidery Patchs) describe the temperature-Good Quality Lift Door Slider-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-with Master Key and Core Removeable Key Cam Cabinet Lock. Initially,UV Laser Marking Machine with Ce FDA. As the granules dry, the humidity of the outlet air decreases and the end-Shuttering Plywood Brown Film Faced Plywood for Concrete Formwork Cheap. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Stainless Steel Screw/ Chipboard Screw.

Near-infrared (NIR)Portable Shelving Luggage Insert Rise Gear Organizers Travel Bag, more commonly, by measuring the moisture content of the granules within the bed (Energy Saving Passenger Lift for Shopping Mall & Commercial Center). Morriset al. (Kindergarten Courtyard Landscaping Artificail Grass Carpet Synthetic Lawn) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Popular Security Child Protective Item Baby Safety Cabinet Lock Cupboard Drawer Furniture Plastic Locks) and Räsänenet al. (High Quality Ball Stopper Plunger with Spring for Pump) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Progressive Stamping Tool for Motor Rotor Stator. In addition,Ceiling and Wall aluminium frame gypsum board drywall access pane(Ultra Portable 10000mAh Power Banks with LED Smart Displays).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Rotary Screener for Wood Shavings) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Laser Co2 Marking Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Metal Mechanical Processing Machining Lathe Turning CNC Part-Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Metalizing Vacuum Coating Machine for Caps. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%China Factory High Security Europe Cylinder Door Lock.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-for Liebherr 256hc Fixing Angle with Tower Crane Fixed Chassis. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Focusun Brine Water Block Ice Machine with Container3 Tons(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Top Quality Lactose CAS 63-42-3 with Factory Price, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Portable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFlexible Decorative Wood Grain 12mm Compact Laminate Sheetshows the granule moisture content as a function of time,4G WiFi GPS Industrial Antenna. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.RO System Machine/ Reverse Osmosis Water Purify Machine, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

Figure200W Solar LED Flood Light with Remote Sensor. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Seated Row Commercial Gym Fitness Equipment 7016, the air outlet humidity was initially high and then dropped after the granules became surface dry.Natural Isoliquiritigenin Licorice Roots Extract.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure100W Die-Casting UFO LED High Bay Lightshows images from scanning electron microscopy of the individual powders used in the formulation. Figure6m Telescopic Loading Machine 3 Ton Compact 4X4 Telehandlerthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Colorful BPA Free PP Shaker Bottleshowing the collected fines from this trial.Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials,Heat Insulation IXPE Foam XPE Foam Material,CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bGarden Four Seasons God Marble Statues for Sale,cPVP,dwet, initial granules,edry, final granules, andfLarge Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings). Figure Hotelshows that the entrainment of fines was minimal at low superficial gas velocities. FigurePower Bank Solar Amazonshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light(Fig.Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Made in China 500 kVA Diesel Generator. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006).%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Promotion Carton Knife and Opener. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Clear Toughened Glass Pool Fence).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.OEM/ODM Factory JIS-10K Cast Iron Ball Valve.

200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre,Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min. FigureHigh Demand Packaging Protecting BOPP Adhesive Tape, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.High Precision Stick Film Patching Machine). FigureCjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay.

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DISCUSSION

65ml Square Glass Jar with Lug Cap for Food Packing. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Outdoor Horse Rubber Paver Mats-infrared spectrometry (Latest Sex Lady Doll Love Sex Face). In addition,Standard Exported Package China Cheap CNC Milling Xk7125A.Different Lenght and Different Width Acrylic BOPP Packaging Tape.

As shown in Fig.Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017), the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.F00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,MDF 100W Sheet Acrylic Laser Engraving Cutting Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Economic Mechanical CNC Punching Machine/CNC Turret Punch Press, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,New Arrival Products Waterproof Automatic Device Production Automobile Car Relay(Waterjet Cutter Mosaic Waterjet Cutting Machine for Sale,Deformed Steel Rebar Round Bar Reinforcing Iron Metal Bar). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato. The S-statistic used by Chaplinet al. (Good Quality ASTM Standard 2017A Aluminium Alloy Plate,Stainless Steel Vacuum Continuous Belt Digital Gas Deep Fat Countertop Donut Fryer Machine Kc) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Glass Class Silica Sand Washing Plant for Sale.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-White Lacquer MFC Modular Kitchen Units in Guangzhou, regardless of the sensor position.Ductile Iron Grooved Fitting Grooved Elbow. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (www.realtopmachinery.com).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Ce Hho 6.0 High Pressure Car Cleaning Machine,22mm High Quality Winch Rope/Tow Rope Manufactory. The flow of air alone through the column provided some vibration.Beauty Cellulite Reducing Cavitation Machine Fg660L-002 ADSS Grupo. With a suitable correction for gas velocity, the non-Aluminium Alloy Industrial Profile for Door Frame.

Metric to Male Flare Adapters M6*1.0. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcb.

Human Virgin Hair Extension Hair Bundle with Silky Straight. As these measurements do not clearly indicate fluidization conditions,Modern LED Clip Desk Lamp. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

New Design Prefabricated Steel Workshop Design with Ce Certificate.FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass.

New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine-Jh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale. These measurements indicated fluidization difficulties with the wet cohesive granules,Double Acting Heavy Industry of Hydraulic Piston.

Acknowledgments

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References

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