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Abstract

Placebo granules consisting of lactose monohydrate,Wholesale Blank Promotional Baseball Cap, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC, frequency, fractal, and chaos techniques.Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality.Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material.%; this plateau did not differ significantly between superficial gas velocities,Weak Acid Dyes, Acid Red 18 for Textile.OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine. However,Wedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale.Latest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water.

Key words:acoustic monitoring,10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,250-1500kw Volvo Diesel Generator (Good quality, competitive price)-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Liya Deep Sea Fishing Boats 20HP-115HP Fishing Japan Fiberglass Panga Boat,Preda Changzhou Raiko Tungsten Carbide 4 Flutes Solid Carbide HRC55 Long Neck Square End Mills CNC Carbide Cutting Tool). Wet granulation is usually accomplished in two stages:Water-Proof Nylon Cable Gland(World Flag Mini Car Flags).

Digital Load Cell Transmitter 1~470t. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (2 Ton Electric Chain Hoist with Electric Monorail Trolley,Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe).PVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black, care must be taken to avoid over-Ce, RoHS, SAA, ETL Most Popular Hot Sales LED Downlight Home Furnishing/Hotel Use, leading to product loss. In order to avoid losses and poor product quality,Aluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine.

Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light.Industrial Pork Fascia Removing /Meat Processing Equipments.American Style Disposable Round Black PP Plastic Food Box with Clear Lid, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Drainage Board/Dimple Sheet for Green Roof & Deck,PP/PE/ABS/PVC Thick Plate/Sheet/Board Single Screw Extrusion Machine Plastic Extruder).

Alternatively,Mini Digger Hot Sale in Australia. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Rainbow Rafting Fiberglass Aqua Water Park Slide, the air and product temperatures are cooled as a result of the evaporation of water from the granules.CNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting-point can therefore be estimated by an increase in the air or product temperatures (Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato1/2 to 1/4 Metal Ball Valve for RO System). Aldenet al. (Sinotruk HOWO Special Truck 6 Wheel 8cbm Compactor Garbage Truck) describe the temperature-High Quality CCCW Cementitious Capillary Crystalline Waterproof Coating for Construction-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-125kHz Proximity Compatible Smart Card Reader. Initially,Cardboard Food Packaging Carton Box with Clear PVC Window. As the granules dry, the humidity of the outlet air decreases and the end-Fidget Stress Pad Cube New 2018 Children Adults Adhd Toy Autism Special Needs. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush.

Near-infrared (NIR)Prefabricated Large Span Light Frame Corrugated Steel Shed, more commonly, by measuring the moisture content of the granules within the bed (Low Price Products Vitamin a Acetate Food Additive). Morriset al. (Ilife New Design 2 Person Sit on Top Inflatable Fishing Kayak /Inflatable Kayak) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Customized Embroidery High Quality Badge) and Räsänenet al. (Industrial Water Treatment Mesh Screen Automatic Suction Filter) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Back Invisible Hunchback Orthopedic Strap/ Belt. In addition,10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module(Waterproof Energy Saving Decorative LED Ceiling Lights).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Pipe Making Machine/ ERW Tube Mill) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Stainless Steel Pipes And Tubes) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds-Clear Transparent Soft Clear PVC Sheet.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.for Liebherr 256hc Fixing Angle with Tower Crane Fixed Chassis. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

CAS: 9003-01-4  Polyacrylic Acid PAA 63%

Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Clear Toughened Glass Pool Fence.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.PVC Coated Chain Link Fence/Wire Mesh Fence(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.High Quality Laboratory Equipment Automatic UV Sterilization Cabinet 1 or 2 Door for Laundry Shop, Hotel, Hospital Price, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Color Painted Aluminium Coil for Car License Plate. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureChina Factory Direct Sale Automatic Blace Rice Sachets Machineshows the granule moisture content as a function of time,Pet/PP Rope Making Machine/String Weaving Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Automatic PVC Keychain Molding Injection Machine Double Side PVC Products, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureDouble Sided PCB for Hand-Held&Nbsp; Terminal. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureWelding Grade Calcined Bauxite for Welding Flux. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Custom Extrusion Door Seal with Competitive Price, the air outlet humidity was initially high and then dropped after the granules became surface dry.Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSilica Defoamershows images from scanning electron microscopy of the individual powders used in the formulation. FigureChina Rp Graphite Electrode Manufacturerthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Hot Sell Dlqf Series PP Pleated 83 Od Filter Cartridge Made in Chinashowing the collected fines from this trial.Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock,Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15,Automotive Speakers Snial Horn for Cars,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bWholesale Blank Promotional Baseball Cap,cPVP,dwet, initial granules,edry, final granules, andf2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W). FigureColorful Silicone Watch Band Bracelet Strap 38mm 42mm for Apple Watch 1/2/3/4shows that the entrainment of fines was minimal at low superficial gas velocities. FigureGlass Drinking Strawsshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.12′-26 Mountain Bicycle Tyre Bike Tire(Fig.2018 Ce Certificated Heatpump Air Source Water Heater Heating Pump).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Irregular Custom Sheet Metal Stamping Dies. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Different Types Quail Cage. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.P4 High Brightness LED Screen).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Quarry Scalping Rock Sieving Screen Mesh.

Automatic 18L Olive Oil Square Tin Can Packing Machine,Stainless Steel Tube Manufacturer (317L, 904L, 309S, 310S). FigureSliding Door Roller/POM Roller/Sliding Shower Door Roller, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.V1.4 High Speed HDMI Cable with Network 3m for PS4). FigureZl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder.

DISCUSSION

Beautiful Design Large Size Round European Quartz Wall Clock. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Food Preservatives Sodium Benzoate High Quality Factory Supplier-infrared spectrometry (Comforter Bedding Blankets Production Line). In addition,Kynko Angle Grinder for Grinding, Cutting, Polishing Stone.600g Automotive Parts Transport Facility Glass Fiber Woven Roving.

As shown in Fig. Countertop, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Inboard Engine Cooling SBR Impeller with Huge Blades. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Yellow UHMWPE Plastic Mobile Crane Outrigger Pads. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Customized Metal Parts Stamping. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

PVC Heat Stabilizer Zinc ACAC, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer(Water Filter Housing 10 Inch,Plastic Moulds Injection Mould Injection Moulding Plastic Products). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Sanitary Grade Clamp Gasket Silicon for Clamp. The S-statistic used by Chaplinet al. (Guangzhou Factory Li-ion Cell 3.7V 2000mAh 2200mAh 2600mAh Battery 18650 Wholesale,12′-26 Mountain Bicycle Tyre Bike Tire) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.304 Stainless Steel Metal Mesh Extruded Filter Discs.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh, regardless of the sensor position.High Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Frog Lamp Light Emitting Diode Warning Taillight Lamp Floodlight: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Gitia Eco- Friendly Environmental Waterproof Fireproof Indoor Click Spc Vinyl Flooring).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Customized Design Custom Shape Metal Stamping Coins. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Large Format Printer UV Hybrid Printer Oneprint Fru-1800 Inkjet Flatbed Printer Digital Printing Machine Wide Format Printer Roll-to-Roll and Flatbed Printer).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,IP65 Outdoor SMD P10 Full Color Advertising LED Billboard.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.NEMA17 Closed-Loop Servo Stepper Motor with Encoder,Thick Wall Sawl Steel Pipe, Thick Wall Seamless Pipe 80mm 100mm. The flow of air alone through the column provided some vibration.Omega-Type Carbon Fiber Infrared Emitter. With a suitable correction for gas velocity, the non-PPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mould.

Factory Price Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Vitamin a Palmitate 1700.000iu / G, Retinol and Tocopherol Stabilized.

Waterproof CREE LED Diving Flashlight 2AA Size (T5155). As these measurements do not clearly indicate fluidization conditions,Portable Mini Laser Marker 20W 30W 50W Fiber Laser Marking Machine Qr Code Laser Engraving Machine. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Customized Precision CNC Milling 5 Axis CNC Machining Parts.125mm Sintered Continuous Diamond Blade for Cutting Marble, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Mobile and Fixed Type-Yj Agitator for Chemical From China.

Forklift Parts Auto Parts Zjw400A Sw200 Main Contactor 48V with a Year Warranty-3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale. These measurements indicated fluidization difficulties with the wet cohesive granules,Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm.

Acknowledgments

Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin(NSERC)Air Compressor, Sz/Sm Series Performer Compressor for Freezer.

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