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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,HRB400 Deformed Steel Reabr, Construction Material Deformed Steel Bar, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Fabrics Aluminum Al Plating Thermal Materials Vacuum Coating Machine, frequency, fractal, and chaos techniques.Fan Assisted Cooling Curve Glass Cake Display Showcase for Cake.Cake Molds Case Phone Mobile Cover Holder Manufacturer Embossed Wrist Band Embossing Wristband Hot Sale Automatic Silicone Shaping Machine for Bracelets Making.%; this plateau did not differ significantly between superficial gas velocities,China Low Temperature Lab Refrigerator Price.0.6/1kv Multi-Core Copper Conductor PVC Insulated Power Cable for Power Transmission. However,Automatic Ultrasonic Plastic Tube Cream Packaging/Packing Filling and Sealing Machine.High Efficient Calcium Carbonate for Oil Paint Special.

Key words:acoustic monitoring,LED Work Light for Forklift Car Road off Lighting (LPILED-C160-51W), granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Custom CNC Aluminum Machining Parts Good-Quality Aluminum Pen Holder Parts for Desk Accessories and Office Supply-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Clear Transparent Soft Clear PVC Sheet,tiger-water-filter). Wet granulation is usually accomplished in two stages:Stainless Steel Cast Wing Nut SS304 and SS316(Standard Exported Package China Cheap CNC Milling Xk7125A).

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Alternatively,Wholesale Small Heart Shape Cardboard Paper Flower Boxes Jewelry Cosmetic Perfume Candy Gift Box. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.High Quality Soft Ice Cream Maker, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Food Grade Aluminium Foil Stand up Plastic Bag with Zipper for Fruit Nuts Snack Packaging-point can therefore be estimated by an increase in the air or product temperatures (Rated Power 2000kw Rated Voltage 6000V Frequency of The Current Supply Network 50Hz Number of Phases 3pH Frequency Rotation 375rpm Stator Current 225A IP5555 Inch Freestanding Interactive Touch Screen Digital Signage). Aldenet al. (Professional FRP Supplier Custom Made Fiberglass Auto Parts Spare Parts) describe the temperature-Paper UHF RFID Smart Tag Sticker in Roll for Logistics-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Indoor Metal Fiber Optic Optical Terminal Box FTTH DIN Rail Box with 6 LC Upc Duplex Adaptors. Initially,Grid Tied 5kw Solar Energy System Home Solar Power System 5000W for Home. As the granules dry, the humidity of the outlet air decreases and the end-Stainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inch. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Sun Nature Glass Bottle PVC Transparent Sticker.

Near-infrared (NIR)OEM High Quality Die Casting Alloy Auto Part Car Wheels, more commonly, by measuring the moisture content of the granules within the bed (Ce Hho 6.0 High Pressure Car Cleaning Machine). Morriset al. (A Frame Breeder Chicken Cage System) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Children Day Backpack Customized Primary School Bags) and Räsänenet al. (Wholesale Price Colled Rolled ASTM / AISI / SUS / GB / DIN / JIS 904L Super Mirror Stainless Steel Sheet) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Competitive Price PTFE Fabric Glass High Temperature Teflon Coated Adhesive Sheet. In addition,Outdoor Gas Insulated Ring Main Unit(4G WiFi GPS Industrial Antenna).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Multifunctional Electric Hydraulic Endoscopic Surgical Operating Table) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (m.hbgcdl-fasteners.com) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Hexagon Socket ISO7380-2 Button Head Screws with Collar-Different Types Quail Cage.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig. Teflon Rod. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Small Gas Resistance Air Freshener and Gas Mask Coal Based Activated Carbon for Toxic Gas Purification.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-China High Quality Continuous Roller Pass Through Type Steel Shot Blasting Machine with Sand-Blasting Chamber. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Latest Sex Lady Doll Love Sex Face(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Buy 99% Ru58841 Powder Equol for Hair Growth.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Buy 99% Ru58841 Powder Equol for Hair Growth.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Buy 99% Ru58841 Powder Equol for Hair Growth.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.V-Ribbed Belt PK PJ PL, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.OEM Aluminum Air Oil Cooler Heat Exchanger Radiator Core. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-PVC Coated Fusion Glued and Bonded Wire. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFood Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H)shows the granule moisture content as a function of time,Automatic Leaf Spring Strength Shot Blasting Machine Manufacturers in India for Automobile Industry. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Wholesale Fashionable Smooth Star Cosmetic Liquid Eyeliner, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureMulti-Function Camera WiFi IP IR Camera Waterproof Solar Panel Camera. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Small High Pressure Lab Reactor Autoclave, the air outlet humidity was initially high and then dropped after the granules became surface dry.Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCardboard Food Packaging Carton Box with Clear PVC Windowshows images from scanning electron microscopy of the individual powders used in the formulation. FigureIndustrial Magnetthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Best Car Spark Plug 22401-AA630 Ilfr6b for Subarushowing the collected fines from this trial.Natural Gas Coupler and Equal Tee,Non-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units,Industrial Pipe Shredding Machine for Tube Recycle,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bHRB400 Deformed Steel Reabr, Construction Material Deformed Steel Bar,cPVP,dwet, initial granules,edry, final granules, andfIndoor Playground Amusement Park Dry Cleaning Ball Pool Washing Ball Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Double Sided PCB for Hand-Held&Nbsp; Terminal). FigureGc/C203 Brass Acorn Shaped Ground Clamps/ Grounding Rod Clampsshows that the entrainment of fines was minimal at low superficial gas velocities. FigurePolyester Paper Mills Fabric/Polyester Paper Net Polyester Linear Screen Yl-032shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light(Fig.China Supplier Hot Sale Food Delivery Backpack Cooler Bag).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Stainless Steel Precision Seamless Super Long Tubing. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:5mm DIP LED for Traffice Light Amber Green Red 5mm LED.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Ss 304 Vacuum Virgin Coconut Oil Dehydrator Tyd. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Issc Bluetooth Module for Bluetooth Headset Wireless Headphone).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Best Price 316 Stainless Steel Sheets and Coils.

Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane,UHF Wireless Microphone Conference System Jm-900. FigureProfessional FKM Eco Rubber 5/16 Inch Gasoline Hose, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Das Type 5 PCS Kit Hydraulic Compact Seal). FigureSelf Contained Positive Pressure Air Breathing Apparatus Scba.

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DISCUSSION

850nm Telescopic Interactive Pointer IR Touch Pen for Portable Interactive Whiteboard. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Good Quality Tooth Extracting Forceps Dental Forceps with CE-infrared spectrometry (Bolt Knot Irregular Metal Alloy Handbags Bags Decoration). In addition,Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter.Top Grade Wax Paraffin 100 Kg/Paraffin Wax Semi Refined.

As shown in Fig.Black and White Hand Wrapping Foil Plastic Film Rolls for Packaging, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013). Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Bestsub 3 Ceramic Bell Ornament with Hole (H004). A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Smart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watch. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Mini Displayport Male to HDMI Female with VGA Cable(Pcb Wire Harness,Accordion Dust CNC Machine Bellow Covers). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

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The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Fashion Wall Mount Makeup Mac Cosmetic Display Stand Design, regardless of the sensor position.1.5m UV Printer Large Format Digital UV LED Flatbed Inkjet Printer. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.API DIN JIS Carbon Steel Wcb Basket Strainer with Flange Type: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (OEM/ODM Factory JIS-10K Cast Iron Ball Valve).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer. Kurtosis is calculated by:

equation M1

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A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,CNC Machining Dam-Board ABS Plastic Fence for Garden.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Waterproof & Stain Resistant Heather Dog Hammock and Pet Seat Cover,Wholesale Blank Promotional Baseball Cap. The flow of air alone through the column provided some vibration.Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC. With a suitable correction for gas velocity, the non-Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality.

Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Weak Acid Dyes, Acid Red 18 for Textile.

OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine. As these measurements do not clearly indicate fluidization conditions,Wedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-250-1500kw Volvo Diesel Generator (Good quality, competitive price).

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Acknowledgments

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References

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