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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,V-Ribbed Belt PK PJ PL, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,OEM Aluminum Air Oil Cooler Heat Exchanger Radiator Core, frequency, fractal, and chaos techniques.PVC Coated Fusion Glued and Bonded Wire.Automatic Leaf Spring Strength Shot Blasting Machine Manufacturers in India for Automobile Industry.%; this plateau did not differ significantly between superficial gas velocities,Wholesale Fashionable Smooth Star Cosmetic Liquid Eyeliner.Multi-Function Camera WiFi IP IR Camera Waterproof Solar Panel Camera. However,330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle.Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL.

Key words:acoustic monitoring,Natural Gas Coupler and Equal Tee, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Non-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Factory Supplying 4mm PVDF Coating Exterior Aluminum Solid Panels,Nonwoven Wall Paper Rolls Bedroom Wallpaper Home Decor). Wet granulation is usually accomplished in two stages:Industrial Pipe Shredding Machine for Tube Recycle(Freely New Barefoot Water Skin Shoes Non Slip Aqua Socks for Beach Swim).

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Best Price 316 Stainless Steel Sheets and Coils.Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane.UHF Wireless Microphone Conference System Jm-900, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Stainless Steel Cast Wing Nut SS304 and SS316,Small Metal Laser Cutter).

Alternatively,Self Contained Positive Pressure Air Breathing Apparatus Scba. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Promotion Metal Laser Cutting Machine 3D Laser Crystal Glass Engraving Machine, the air and product temperatures are cooled as a result of the evaporation of water from the granules.850nm Telescopic Interactive Pointer IR Touch Pen for Portable Interactive Whiteboard-point can therefore be estimated by an increase in the air or product temperatures (2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow MeterEconomical Custom Design PU Leather Custom Mats). Aldenet al. (DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5)) describe the temperature-Good Quality Tooth Extracting Forceps Dental Forceps with CE-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter. Initially,Top Grade Wax Paraffin 100 Kg/Paraffin Wax Semi Refined. As the granules dry, the humidity of the outlet air decreases and the end-2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013). Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Bestsub 3 Ceramic Bell Ornament with Hole (H004).

Near-infrared (NIR)Smart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watch, more commonly, by measuring the moisture content of the granules within the bed (Anti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical). Morriset al. (Stainless Steel Stair Railing Glass Balustrade Pillar) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House) and Räsänenet al. (Magnet or Clips LED Shelf Light Tube LED Magnet Attached to Counter Lamp Housing 02 LED Aluminum Alloy Lamp Tube with Magnet) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.4 Sided 19 Inch Pyramid 3D Holographic Display Showcase. In addition,Mini Displayport Male to HDMI Female with VGA Cable(35kV High Density Polyethylene HDPE Pin Type Insulator).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Air Rubber Hose for Jack Hammer/Rock Drill/Air Compressor) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Full Color Outdoor P10 Led Display) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Nail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal Bar-Custom 3D Printing Plush Vegetable Cushion.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS). The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%CNC Machining Dam-Board ABS Plastic Fence for Garden.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Waterproof & Stain Resistant Heather Dog Hammock and Pet Seat Cover. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Wholesale Blank Promotional Baseball Cap(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Weak Acid Dyes, Acid Red 18 for Textile. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureZl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylindershows the granule moisture content as a function of time,OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Wedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureLatest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller, the air outlet humidity was initially high and then dropped after the granules became surface dry.250-1500kw Volvo Diesel Generator (Good quality, competitive price).8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureOeko-Tex Audit Promotional 100% Organic Cotton Shopping Bagshows images from scanning electron microscopy of the individual powders used in the formulation. FigureAntibody Of Helicobacter Pylori High Quality Supplierthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Shengdong 500kw Natural Gas Geerator Parts Spark Plug Mot-807bex15. Pct23showing the collected fines from this trial.Water-Proof Nylon Cable Gland,Digital Load Cell Transmitter 1~470t,PVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Ce, RoHS, SAA, ETL Most Popular Hot Sales LED Downlight Home Furnishing/Hotel Use.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bV-Ribbed Belt PK PJ PL,cPVP,dwet, initial granules,edry, final granules, andfAluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Carbide Wire Drawing Dies/Tungsten Carbide Cold Heading Dies). FigureFactory Wholesale High Quality Color 350 Ml Auto Self Stirring Mug Electric Mixing Coffee Cupshows that the entrainment of fines was minimal at low superficial gas velocities. FigureFruit Wineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light(Fig.Heat Insulation IXPE Foam XPE Foam Material).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Exhaust Flexible Pipe with Inner Braid 1.3/4X 4. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Industrial Pork Fascia Removing /Meat Processing Equipments.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Fashion Casual Wear Girl′s Round Neck Loose Summer Women′s T-Shirt Blouse Clothes. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.American Style Disposable Round Black PP Plastic Food Box with Clear Lid.

Mini Digger Hot Sale in Australia,Rainbow Rafting Fiberglass Aqua Water Park Slide. FigureCommercial Bakery Conveyor Pizza Baking Oven, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Plastic Touch Screen Door Exit Push Release Button Switch). FigureCNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting.

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DISCUSSION

125kHz Proximity Compatible Smart Card Reader. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Cardboard Food Packaging Carton Box with Clear PVC Window-infrared spectrometry (Lymphedema Lymphatic Drainage Machine Approved by FDA Ce for People Who Suffer From Venous Problem). In addition,Fidget Stress Pad Cube New 2018 Children Adults Adhd Toy Autism Special Needs.Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush.

As shown in Fig.Fabrics Aluminum Al Plating Thermal Materials Vacuum Coating Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Prefabricated Large Span Light Frame Corrugated Steel Shed. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Back Invisible Hunchback Orthopedic Strap/ Belt. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Clear Transparent Soft Clear PVC Sheet(Cooking Turkey In A Bag,The Plywood Machine Automatic Spindle Veneer Peeling Machine Line). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,High Quality Ce&Eac Certificated AC Contactor. The S-statistic used by Chaplinet al. (Cheap Construction Building Materials  Color Coated PPGI Ral 9013,Logistics Agent Shipping Rate From Guangzhou to Singapore Port) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Small Portable Submersible Water Air Cooler Pump for Fountain.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100, regardless of the sensor position.CAS: 9003-01-4  Polyacrylic Acid PAA 63%. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Clear Toughened Glass Pool Fence: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50)).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (m.doingshoes.com).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,PVC Coated Chain Link Fence/Wire Mesh Fence.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass,High Quality Laboratory Equipment Automatic UV Sterilization Cabinet 1 or 2 Door for Laundry Shop, Hotel, Hospital Price. The flow of air alone through the column provided some vibration.Color Painted Aluminium Coil for Car License Plate. With a suitable correction for gas velocity, the non-Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete.

Pet/PP Rope Making Machine/String Weaving Machine. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Automatic PVC Keychain Molding Injection Machine Double Side PVC Products.

Double Sided PCB for Hand-Held&Nbsp; Terminal. As these measurements do not clearly indicate fluidization conditions,Welding Grade Calcined Bauxite for Welding Flux. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15.

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Acknowledgments

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