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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Manufacturer Yoga Fitness Exercise TPE Foam Balance Pad

Abstract

Placebo granules consisting of lactose monohydrate,300W-1000kw Horizontal Axis Wind Generator/Permanent Magnet Generator, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS), frequency, fractal, and chaos techniques.Sanitaryware Parts Metal Rubber Bonding Mechanical Seal.High Temperature Resist Non-Stick Pizza Mesh Tray.%; this plateau did not differ significantly between superficial gas velocities,Two Inches Target Head Vacuum Magnetron Sputtering Coater for Laboratory.45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank. However,OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car.Self Locking Tear Away Plastic Pull up Seal.

Key words:acoustic monitoring,Breathable 2PC Car Seat Cover Pad, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Aluminum Camlock Plugs Fitting-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Self Locking Tear Away Plastic Pull up Seal,Portable Mini Small Vertical Industrial Arm Electric Tapping Machine). Wet granulation is usually accomplished in two stages:Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price(Imported High - Quality Wear-Resistant Double Lip Spring Oil Seal).

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Dsq Type Solenoid Valve Coil Connector.Dhg3 Speaker for High Frequency with Small Size.ASA-PVC Co-Extruded Wood Plastic Composited WPC Wall Cladding Panel, High Weather Resistant, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (SMC Af2000-02 Air Filter Regulator Lubricator,Anti-Theft Door Machine High Quality Supplier).

Alternatively,20d Interlock TPU Bonding Fabric 100% Polyester Tight Knit 44 Gauge Lining Cloth. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Best Car Spark Plug 22401-AA630 Ilfr6b for Subaru, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure)-point can therefore be estimated by an increase in the air or product temperatures (Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage MachineExercise Washable Foam Pilates Wholesale Custom Printed TPE Yoga Mat). Aldenet al. (Replacement OEM filter P527078 donaldson torit dust collector spare parts cartridges cement air filter for air purification system) describe the temperature-OEM Forge/Forging Part/Forged Iron Heads/Steel Forged-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-12mm Environmental Wear-Resisting Laminated Flooring. Initially,Tent Fabric with Full Blackout Silver Coatings/Waterproof. As the granules dry, the humidity of the outlet air decreases and the end-China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Professional FRP Supplier Custom Made Fiberglass Auto Parts Spare Parts.

Near-infrared (NIR)PCD Drawing Dies for Drawing Steel Wire, more commonly, by measuring the moisture content of the granules within the bed (Fire Protective Gloves). Morriset al. (Concrete Mixing Truck) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Customized High Quality Board Game - Global World Adventure Board Game) and Räsänenet al. (Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.ALUMINUM GAS REGUALTOR, ALUMINUM GAS VALVE, BIG SIZE. In addition,Stainless Steel Precision Seamless Super Long Tubing(Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Featured) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabric-Oil Resistant NBR Rubber Profile Rubber Cord.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.OEM Forge/Forging Part/Forged Iron Heads/Steel Forged. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Stainless Steel Welded Pipes 304 Square Finish Polished.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Vertical Mechanical Shaker Table for Vibration Testing System. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Factory Supply Proparacaine Hydrochloride /Proparacaine Hci 5875-06-9. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Chain Sprocket Transmission Gear (06B, 08B). Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureDisposable 2PCS Luxury Towels Dry Wipes for Travel Hotel BBQshows the granule moisture content as a function of time,Elastic Tapes Automatic Screen Printing Machine with 30cm Width. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureImported High - Quality Wear-Resistant Double Lip Spring Oil Seal. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureCustom Made Metal 3D Printing Parts 3D Machining Service. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.3000 Watt  12V/24V/48V DC to AC 110V/220V/230V Pure Sine Wave Solar Power Inverter, the air outlet humidity was initially high and then dropped after the granules became surface dry.Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureEmbossed Synthetic Artificial Coated Vacuum Leather for Shoes Bagsshows images from scanning electron microscopy of the individual powders used in the formulation. Figurewww.miracle-leather-bag.comthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Semi Automatic Pet Blow Moulding Machine Price Blow Moulding Machineshowing the collected fines from this trial.Sheet Metal Fabrication CNC Machining Welding Part,China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House,Automatic Broiler Chicken Slaughter Machine Slaughtering Line,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b300W-1000kw Horizontal Axis Wind Generator/Permanent Magnet Generator,cPVP,dwet, initial granules,edry, final granules, andfLeaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light). FigureFilter Press for Sandplant Sludge Treatmentshows that the entrainment of fines was minimal at low superficial gas velocities. FigureEdison Led Bulb Lampshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Yrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit(Fig. Double Braided Rope).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Automatcial Granite Marble Slab Polishing Line Machine. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Carbon Steel Standard Tube Fitting Union Tee.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345)).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Most Popular 200watt Modified Sine Wave Power Car Inverter.

Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345),160lm/W 1200W LED Stadium Sport High Mast Flood Light. FigureHigh Guality Conference Hall High Back Auditorium Chair (FECMP07), however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Ubs Charging GPS102b for Personal Tracking). FigureDifferent Pattern Paper Craft Hole Punch for Festival Papers and Greeting Card.

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Centrifugal Open Impeller Paper Sugar Stock Flushing Water Pump

DISCUSSION

(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Fan Coil Filters, Fan Coil Unit Filters, Ceiling Filters-infrared spectrometry (0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil). In addition,Steel Crimped Wire Mesh, Mining Screen Mesh, Square Wire Mesh.Good Price Factory 75 Series BLDC High Torque Brushless DC Motor.

As shown in Fig.a-Grade Cell Transparent 200W Mono Solar Panel with Best Price, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Ce Vertical Automatic Insulating Double Glazing Glass Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

for iPhone Low Prices Earpods with Lightning Connector Good Quality, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Galvanized Iron Material British Type Hose Clamp Used for Pipe(Aluminum Nickel Alloys,Air Cooler/Evaporative Air Cooler). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting. The S-statistic used by Chaplinet al. (Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for Man,Breathable 2PC Car Seat Cover Pad) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-ANSI150 Fluorine Lined Butterfly Valve Lug Type, regardless of the sensor position.Size 00 Wholesale Bulk Empty Hard Gelatin Capsules. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Keno-L102 Good Quality Hologram Strip Label Labeling Machine: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (High Quality Soft Ice Cream Maker).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Sheet Metal Deep Draw Parts).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Electrostatic Powder Coating Spray Gun (Colo-800D-L2-B),Semi-Auto Blowing Machine for Pet Bottles Molding Production. The flow of air alone through the column provided some vibration.Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India. With a suitable correction for gas velocity, the non-High Demand Packaging Protecting BOPP Adhesive Tape.

8 Nozzles Liquid Filling Equipment. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge.

Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229). As these measurements do not clearly indicate fluidization conditions,China Factory Price Standard Size Hot Cold Rolled Galvanised Coil. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

CNC Machining Precision Customized Mechanical Parts.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve.

100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17)-20FT Sandwich Panel Container House for Office Building. These measurements indicated fluidization difficulties with the wet cohesive granules,Insulating Glass 2500 Glass Washing Machine.

Acknowledgments

4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L(NSERC)Customized Precision Auto Spare Turning Metal CNC Aluminum Parts.

References

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