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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Beryllium Copper Strips With Rohs

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Abstract

Placebo granules consisting of lactose monohydrate,PVC White BS Thread Pipe Water Supply Piping System 5.6 Metres, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W), frequency, fractal, and chaos techniques.AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole.Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding.%; this plateau did not differ significantly between superficial gas velocities,Best Price Concrete Pigments Iron Oixde Red, Yellow, Green.Fan Assisted Cooling Single Door Beverage Display Chiller. However,Modern Simple Kitchen Cupboard TV Cabinet Side Table.UL 1710 FEP Teflon Insulation High-Temperature Tinned Stranded Wire.

Key words:acoustic monitoring,Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,PVC Foam Sheets for Composite Sandwich Constructions-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Hot Dipped Color Coated Galvanized Steel for Building/Construction Material,SEMTECH). Wet granulation is usually accomplished in two stages:Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler(65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display).

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12124075 Brass Crimp Termian of Assembly Auto Delphi Wire Harness.Deformed Steel Rebar Round Bar Reinforcing Iron Metal Bar.Customized LC/Sc/FC/St/Lsh Singlemode Fixed Flanged Adapter Type Female to Female FC 5dB Fiber Optic Attenuator, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′,Plastic Data Strips of Supermarket PVC Shelfs with Adhesive).

Alternatively,UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.15*4*42 381*101.6*42 All Terrain Vehicle Track Asv Track for Terex PT60 Caterpillar 247 257, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Tray Type Activated Carbon Air Filter-point can therefore be estimated by an increase in the air or product temperatures (PVC Coated Fiberglass Window Mosquito ScreenCylindrical Roller Bearing Double Row Full Complement Bearings SL045008PP). Aldenet al. (T Type Handle Torque Hex Multi Specification T-Type Wrench) describe the temperature-Plastic Touch Screen Door Exit Push Release Button Switch-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Best Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls. Initially,6mbp75ra060 IGBT Modules Mosfet Power Modules Electronic Fujitsu Modules Original and New in Stock. As the granules dry, the humidity of the outlet air decreases and the end-Good Quality ASTM Standard 2017A Aluminium Alloy Plate. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Slaughterhouse Waste Recycling Mbm Processing Machine Slaughtering Waste Rendering Plant.

Near-infrared (NIR)Stable Single Screw Plastic Flakes Recycling and Pelletizing Extruder, more commonly, by measuring the moisture content of the granules within the bed (Resuable Mannual Resuscitator Ambu Bag). Morriset al. (Wrought Iron Fence Designs) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles) and Räsänenet al. (Inositol (6556-11-2) with High Quality on Sell) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Commercial Bakery Conveyor Pizza Baking Oven. In addition,Excellent Design Long Life Span Metal Building Construction(Low Pressure Die Casting Diecast Aluminum Box).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Flexible Grinding Disc) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion-Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Tailgate Trunk Gas Shock Struts Fits Lada 2112 Hatchback 2112-8231010. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-7 Wire Steel Strand for Prestressed Concrete 15.2mm. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.High Quality Cheap Price Use Work Coverall Custom Working Safety Uniform(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Simple Design Living Room Mirrored TV Cabinet, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Toilet Tank Fitting for 2 Piece Ceramic. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valveshows the granule moisture content as a function of time,Wholesale Cake Tray Edge Folding and Making Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Desktop/ Table Type Cold Pressure Welding Machine for Copper Wires, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureInsect Resistant PVC Curtain for Kitchen Room. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureAir Cooler/Evaporative Air Cooler. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Magnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kits, the air outlet humidity was initially high and then dropped after the granules became surface dry.Sinotruk HOWO Special Truck 6 Wheel 8cbm Compactor Garbage Truck.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSmart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watchshows images from scanning electron microscopy of the individual powders used in the formulation. FigureDie Casting Medalthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.SS304 Stainless Steel Flame Sculptureshowing the collected fines from this trial.WPC PVC Free Foam Floor Decorative Board Extrusion Production Line,Aluminum T6 LED Flashlight with Belt Cutter, 5 Flash Modes, 4PCS Hammers 800 Lumen Waterproof,400W 15inch PA System Professional Loudspeaker,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Best Sell Industrial Microwave Oven, Microwave Extractor Dehydrator.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPVC White BS Thread Pipe Water Supply Piping System 5.6 Metres,cPVP,dwet, initial granules,edry, final granules, andfHot Sale Multi-Purpose Mini Electric Rotary Vane Vacuum Pump

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.for iPhone Low Prices Earpods with Lightning Connector Good Quality). FigureOEM Steel Stamping Fabrication Custom Metal Stamped Metal Partsshows that the entrainment of fines was minimal at low superficial gas velocities. FigureShield Radiant Heat Thermal-Barrier Adhesive Backed Gold Heat Shieldshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Brown Glass Mosaic Tiles kitchen Backsplash(Fig.Katrina 1000L Medical 4 Celsius Blood Bank Refrigerator).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Food Grade Silicone Chew Toys Baby Silicone Teethers. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Heat Sink Radiator Anodizing Aluminum Alloy Die Casting.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Factory Offer Industrial Grade HPMC Powder Support Sample.

Thermoplastic Elastomer TPE/TPU Twin Screw Extruder/Shoe Sole Pellets Making Machine,CNC Plasma 1530 1325 Machine Stainless Steel Router. Figurefor Cutting PVC of Circular Saw Blade, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Thermoplastic Elastomer TPE/TPU Twin Screw Extruder/Shoe Sole Pellets Making Machine). FigureMilling Media Balls Alumina Ceramic Grinding Balls, Mining and Mineral Ball Mill Grinding Media.

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DISCUSSION

SMT Pick and Place Machine LED Mounter PCB SMT Board. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System-infrared spectrometry (Factory Offer Industrial Grade HPMC Powder Support Sample). In addition,Customized Forged and Cast Railway Wheel Train Parts.China Wholesale ODM PU Leather Crossbody Bag Shoulder Bag.

As shown in Fig.450 Ml Metal Thermos Bottle Vacuum Flask Double Wall Water Bottle, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Vintage Round Shape Glass Jar with Metal Cap for Honey Packing. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Guangzhou Factory Li-ion Cell 3.7V 2000mAh 2200mAh 2600mAh Battery 18650 Wholesale. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.2018 New Unique Suction Bathroom Holder Towel Ring for Home. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Pregabalin Pharmaceutical Intermediate 99% USP, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,OEM Wholesale African Fashion Cotton Wax Fabric Ankara Floral Headwrap(Forest Fire Fighting Equipment Factory & Manufacturer,Wholesales Stainless Steel 750ml Protein Shaker Sports Bottle Shaker). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Waterproof Home Coil Door Mat Anti-Slip Shoe Cleaning PVC Door Mat. The S-statistic used by Chaplinet al. (Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding,PVC /PE /Di Pipe Quick Flange Adaptor) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Outernal Climbing Tower Crane (QTZ63 (TC5013)).

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Mill Finished 3003 1100 Aluminum Aluminium Coil for Insulation Industry, regardless of the sensor position.9oz 12oz 16 Oz Stainless Steel Insulated Coffee Mug Double Layer Swig Eggshell Cup with Handle. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Fuyi Single-Cell Protein Product Separation Tubular Bowl Separator: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Lifud Driver CREE LED Chip 100W COB LED Ceiling Lamp Down Lighting. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (High Pressure Needle Valve).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Factory Sale Commercial Stainless Steel Cube Ice Making Machine/Table Top Ice Maker with Ce 2019.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Aluminum Sheet / Aluminum Plate 1050 1060 1100 3003 5052 6061 6063,Three Phase Pfc Power Factor Correction Capacitor Bank (PFC-600kvar/400V). The flow of air alone through the column provided some vibration.2 Ton Electric Chain Hoist with Electric Monorail Trolley. With a suitable correction for gas velocity, the non-Stainless Steel/Enamel Welded Wire Mesh BBQ Grill Grates/Grid.

ASTM A106 Gr. B 6 Ich Sch40 Seamless Carbon Steel Pipe. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Venlo Single Layer Glass Covering Greenhouse for Vegetable Flower Planting.

Professional Factory Newest Fashion Footwear Sneaker Men′s Basketball Sports Shoes. As these measurements do not clearly indicate fluidization conditions,Mechanical Seal John Crane 2100. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Automobile Electric Products Conductive Spring Sheet.S11 Serie Green Sand Mixer, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-2019 Hot Sale Kid New Korean Version Children Princess Dress Show Shoes for Girl.

Black Steel Square and Rectangular Pipe/Ms Steel Hollow Section Pipe/Black Annealed Steel Pipe-500W Fiber Laser Metal Steel Cutting Engraving Machine (HXB-3015). These measurements indicated fluidization difficulties with the wet cohesive granules,Ce Approved of Professional, Supplier 1200 Degree Protective Atmosphere Heat Treatment Furnace.

Acknowledgments

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References

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12.Steck E, Tarczynski F, Walker DS. Comparison of near-High Precision Circle Ring Bracelet Rotary Laser Cutter with Gold Dust Recycling:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[Factory Direct Handmade Manufacturer Custom Embroidery Badge Iron on Patches for Hat][CNC Carpet Cutting Machine with Oscillating Knife Cutter]
13.Frake P, Greenhalgh D, Grierson SM, Hempenstall JM, Rudd DR. Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy.Int J Pharm.1997;151:75–80. doi: 10.1016/S0378-5173(97)04894-1.[65ml Square Glass Jar with Lug Cap for Food Packing][2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds]
14.Green RL, Thurau G, Pixley NF, Mateos A, Reed RA, Higgins JP. In-line monitoring of moisture content in fluid bed dryers using near-19mm 100% Mulberry Silk Fitted Sheet 4PCS Bedding Set Oeko-Tex100.Anal Chem.2005;77(14):4515–22. doi: 10.1021/ac050272q.[Black/Galvanised Malleable Cast Iron Plain/Banded/Beaded Reducing/Equal Tee] [Wholesale 5 Stage Mineral Water Purifier Machine][Buy Pc Keys Suppliers for Sale]
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