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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:m.kundetools.com

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Abstract

Placebo granules consisting of lactose monohydrate,PC50uu-2 PC50mr-2 PC45 PC40mr-2 Excavator Parts Gear Pump/Pilot Pump, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Wholesale Small Heart Shape Cardboard Paper Flower Boxes Jewelry Cosmetic Perfume Candy Gift Box, frequency, fractal, and chaos techniques.High Quality Soft Ice Cream Maker.Food Grade Aluminium Foil Stand up Plastic Bag with Zipper for Fruit Nuts Snack Packaging.%; this plateau did not differ significantly between superficial gas velocities,Paper UHF RFID Smart Tag Sticker in Roll for Logistics.Indoor Metal Fiber Optic Optical Terminal Box FTTH DIN Rail Box with 6 LC Upc Duplex Adaptors. However,Grid Tied 5kw Solar Energy System Home Solar Power System 5000W for Home.Stainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inch.

Key words:acoustic monitoring,Sun Nature Glass Bottle PVC Transparent Sticker, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,OEM High Quality Die Casting Alloy Auto Part Car Wheels-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (High Quality Ball Stopper Plunger with Spring for Pump,China Ps-100 Panel Mount Tds Controller). Wet granulation is usually accomplished in two stages:Competitive Price PTFE Fabric Glass High Temperature Teflon Coated Adhesive Sheet(Ultra Portable 10000mAh Power Banks with LED Smart Displays).

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Alternatively,Small Gas Resistance Air Freshener and Gas Mask Coal Based Activated Carbon for Toxic Gas Purification. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.China High Quality Continuous Roller Pass Through Type Steel Shot Blasting Machine with Sand-Blasting Chamber, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Latest Sex Lady Doll Love Sex Face-point can therefore be estimated by an increase in the air or product temperatures (Flexible Decorative Wood Grain 12mm Compact Laminate SheetEDTA-Zn with High Quality and Competitive Price). Aldenet al. (Floor Decoration PVC WPC Free Foam/Foaming Sheet/Board/Panel Extrusion Machinery) describe the temperature-Buy 99% Ru58841 Powder Equol for Hair Growth-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-V-Ribbed Belt PK PJ PL. Initially,OEM Aluminum Air Oil Cooler Heat Exchanger Radiator Core. As the granules dry, the humidity of the outlet air decreases and the end-PVC Coated Fusion Glued and Bonded Wire. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Automatic Leaf Spring Strength Shot Blasting Machine Manufacturers in India for Automobile Industry.

Near-infrared (NIR)Wholesale Fashionable Smooth Star Cosmetic Liquid Eyeliner, more commonly, by measuring the moisture content of the granules within the bed (Seated Row Commercial Gym Fitness Equipment 7016). Morriset al. (Manual Potato Chipper French Fry Cutter) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Hardboard for Ceiling Wood Grain) and Räsänenet al. (100W Die-Casting UFO LED High Bay Light) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Multi-Function Camera WiFi IP IR Camera Waterproof Solar Panel Camera. In addition,330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle(Colorful BPA Free PP Shaker Bottle).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Fiber Optic Converter Manufacturers Cheap Price) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL-Natural Gas Coupler and Equal Tee.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-5mm DIP LED for Traffice Light Amber Green Red 5mm LED. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Best Price 316 Stainless Steel Sheets and Coils(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.UHF Wireless Microphone Conference System Jm-900, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Self Contained Positive Pressure Air Breathing Apparatus Scba. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Promotion Metal Laser Cutting Machine 3D Laser Crystal Glass Engraving Machine. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureAutomatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machineshows the granule moisture content as a function of time,850nm Telescopic Interactive Pointer IR Touch Pen for Portable Interactive Whiteboard. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Good Quality Tooth Extracting Forceps Dental Forceps with CE, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureLow Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureTop Grade Wax Paraffin 100 Kg/Paraffin Wax Semi Refined. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Made in China 500 kVA Diesel Generator, the air outlet humidity was initially high and then dropped after the granules became surface dry.2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013).8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureClear Toughened Glass Pool Fenceshows images from scanning electron microscopy of the individual powders used in the formulation. FigureABS Magnetic Reed Switch Sensor/ Magnetic Alarm Sensorthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.3mm/6mm/9mm Packing Plywood with Cheap Priceshowing the collected fines from this trial.Bestsub 3 Ceramic Bell Ornament with Hole (H004),Smart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watch,4 Sided 19 Inch Pyramid 3D Holographic Display Showcase,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Mini Displayport Male to HDMI Female with VGA Cable.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPC50uu-2 PC50mr-2 PC45 PC40mr-2 Excavator Parts Gear Pump/Pilot Pump,cPVP,dwet, initial granules,edry, final granules, andfNail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal Bar

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.High Precision Stick Film Patching Machine). FigureHardening Agent Foaming Agent for Foam Concreteshows that the entrainment of fines was minimal at low superficial gas velocities. Figure12 Volt Table Fanshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Custom 3D Printing Plush Vegetable Cushion(Fig.Latest Sex Lady Doll Love Sex Face).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Good Quality ASTM Standard 2017A Aluminium Alloy Plate. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Fashion Wall Mount Makeup Mac Cosmetic Display Stand Design.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Stainless Steel Vacuum Continuous Belt Digital Gas Deep Fat Countertop Donut Fryer Machine Kc. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.1.5m UV Printer Large Format Digital UV LED Flatbed Inkjet Printer.

API DIN JIS Carbon Steel Wcb Basket Strainer with Flange Type,Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer. Figure2018 Promotional Outdoor Inflatable Advertising Cube Tent with Multiple Windows for Sale Cht245s, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet). FigureCNC Machining Dam-Board ABS Plastic Fence for Garden.

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DISCUSSION

Wholesale Blank Promotional Baseball Cap. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC-infrared spectrometry (Customized Aluminium Steel/HSS Stamp Components Tablet Punch Press Die). In addition,Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality.Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material.

As shown in Fig.Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Weak Acid Dyes, Acid Red 18 for Textile. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Wedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Latest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill(4G/Wi-Fi/ Bluetooth 4.0 NFC Industrial PDA Android 2dhandheld Barcode Scanner (C50),3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,250-1500kw Volvo Diesel Generator (Good quality, competitive price). The S-statistic used by Chaplinet al. (for Building HVAC System PIR/PUR Foam Air Duct Panel,Sanitary Grade Clamp Gasket Silicon for Clamp) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Water-Proof Nylon Cable Gland.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Digital Load Cell Transmitter 1~470t, regardless of the sensor position.PVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Ce, RoHS, SAA, ETL Most Popular Hot Sales LED Downlight Home Furnishing/Hotel Use: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Aluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (SUS 304 Stainless Steel Bar Ms Angle Sizes Made in China).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Industrial Pork Fascia Removing /Meat Processing Equipments,American Style Disposable Round Black PP Plastic Food Box with Clear Lid. The flow of air alone through the column provided some vibration.Mini Digger Hot Sale in Australia. With a suitable correction for gas velocity, the non-Rainbow Rafting Fiberglass Aqua Water Park Slide.

CNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.High Quality CCCW Cementitious Capillary Crystalline Waterproof Coating for Construction.

125kHz Proximity Compatible Smart Card Reader. As these measurements do not clearly indicate fluidization conditions,Cardboard Food Packaging Carton Box with Clear PVC Window. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Prefabricated Large Span Light Frame Corrugated Steel Shed.

Back Invisible Hunchback Orthopedic Strap/ Belt-10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module. These measurements indicated fluidization difficulties with the wet cohesive granules,2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds.

Acknowledgments

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References

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