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Abstract

Placebo granules consisting of lactose monohydrate,M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Qt12-15 Automatic Cement Block Moulding Machine with SGS, frequency, fractal, and chaos techniques.Factory Price Pre Galvanized Steel Pipe Electrical Cable Conduit.TBB Model Electric Counterbalance Stacker.%; this plateau did not differ significantly between superficial gas velocities,Water Softener Underground Water Treatment Alkaline Water Industrial Filter Machine.99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives. However,Dust Tester-Dust Concentration Detector-Portable Pm2.5 Detector-Smoke Detector, R & D Sales[Onetest].Diamond Stone Cutting Blade Circular Saw Blades for Concrete.

Key words:acoustic monitoring,Yellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,High Quality Restaurant Wooden Dining Room Chair with Leather Seat-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Custom Power Bank PCBA Board Assembly PCB Manufacturer,Anti-Finger Print Galvanized Steel Coil Full Hard Aluzinc Steel Sheet). Wet granulation is usually accomplished in two stages:Drop Forged One Way Load Buckle(Made in China 3 Axle 40cbm Cement Silo Trailer).

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Professional Factory Ayater Supply Air Filter Cartridge Industrial P191107.Diamond Glass Plate Dessert Plate Vegetable and Fruit Salad Plate.Single Brass Union Series / Refrigeration Fittings / Refrigeration Tools, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Top Grade Wax Paraffin 100 Kg/Paraffin Wax Semi Refined,China Compostable Fork).

Alternatively,Lt8003u/Lt8005u High Performance UV Laser Marking Printer. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Pest Glue Trap Electric Control System Mosquito Killer and Insect Trap with Adhesive Pad 8W 16W UV Lamp, the air and product temperatures are cooled as a result of the evaporation of water from the granules.100% Pure Laminating Plywood and MDF Melamine Powder for Melamine Formaldehyde Resin Use-point can therefore be estimated by an increase in the air or product temperatures (Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with MeshFactory Price Aluminium Sheet Used for Mould 2A12). Aldenet al. (Vertical Mechanical Shaker Table for Vibration Testing System) describe the temperature-Black Walnut/EV Teak/Ash Veneer Fancy Commercial Plywood with Low Price-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-2018 Hot Sale Good Quality Sponge Iron Supplier Best. Initially,Rectangular Air Pipe Sheet Pneumatic Duct Bending Machine for Sale. As the granules dry, the humidity of the outlet air decreases and the end-Professional Plastic Injection Molding/Mold Plastic Part Manufacturer in China. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Fiberglass Fishing Cabin Boats for Sale.

Near-infrared (NIR)Cold Rolled Stainless Steel 304 Tubes Hollow Pipe, more commonly, by measuring the moisture content of the granules within the bed (Aluminum Bar Punching Machine). Morriset al. (Zirconium Hydride Factory & Manufacturer) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Cold Rolled Stainless Steel 304 Tubes Hollow Pipe) and Räsänenet al. (Water-Removal Turbine Oil Flushing Machine (TY)) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Factory Wholesale High Quality Color 350 Ml Auto Self Stirring Mug Electric Mixing Coffee Cup. In addition,059 Factory Bimetal Thermometer(Box/Square Type Column Vertical Drilling Machine (Z5150B)).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Investment Casting Stainless Steel Screwed 90 Degree Street Elbow) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Titanium Dioxide Rutile And Anatase) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Chinese Hot Sale Wood 3D CNC Router Wood Working Tools Mini Woodworking Machine-Ce Approved Warehouse Storage Heavy Duty Steel Stacking Pallet Rack.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat Band.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Gorgeous Brazilian Human Milky Way Hair Crochet Braid. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Disposable Coin Compressed Magic Face Towel for Beauty(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Silicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Silicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Silicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Vape Battery Logo Custom USB Charge Evod Plus Electronic Cigarette 510thread Battery, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Fast Obvious 4 in 1 Cavitation Vacuum Liposuction Machine (VS-101). The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Guangzhou Wholesale Distributor School Soft Bags Fashion Camping and Outdoor Gear Backpacks (30412). Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure Mining Screen Meshshows the granule moisture content as a function of time,High Quality Customized Alumina Ceramic. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.72W Rolling Thin Film Solar Panel Flexible (PVL-72), based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureCheap Felt Disposable Indoor Bathroom Guest Slippers Hotel Use. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureChusheng 40FT Container Cargo Wall Side Semi-Trailer Price. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.1390 CO2 Laser Engraving and Cutting Machine for Plastic, the air outlet humidity was initially high and then dropped after the granules became surface dry.Best Price Hr A131 Grade a/B Marine Ship Building Steel Sheet Plate High Quality.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHigh Sticky Adhesive Double Sided PE Foam Removable Tape (RMPES10)shows images from scanning electron microscopy of the individual powders used in the formulation. Figure100% Polyester Disperse Printing Microfiber Fabric 235cm Width 90GSM for Bedding Setsthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Warranty Two Years 24V DC High Bright White PCB LED Strip Lightshowing the collected fines from this trial.High Quality Supply 4pole MCB Type Dual Power Automatic Transfer Switch ATS,Chicken Dung Organic Fertilizer Granulating Machine,Stainless Steel Pre Water Filter,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%China Factory Customized Precision Optical Lens.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bM24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm,cPVP,dwet, initial granules,edry, final granules, andfSuper LED with Solar Power Traffic Warning Lamp

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light). FigureFactory Price Medical China Hemodialysis Machine/ Mobile Dialysisshows that the entrainment of fines was minimal at low superficial gas velocities. Figurewww.wanxuanglass.comshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Safe and Highly Reliable Machine CNC Cutting Machine Abrasive Waterjet(Fig.Rifle Swing Hydraulic Cylinder).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Bulk Manufacturer Food Grade Gellan Gum. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:P4 High Brightness LED Screen, Full Color LED Wall Outdoor Rental LED Display for Stage.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Lifud Driver CREE LED Chip 100W COB LED Ceiling Lamp Down Lighting).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Shark′s Mouth Shape Stainless Steel Buckle Connect with 1.5m Webbing.

Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve,Flange Seamless Stainless Steel Pipe Fitting. FigureIGBT Medium Frequency Electric Induction Heating Forge Furnace, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Progressive Stamping Tool for Motor Rotor Stator). FigureFire Emergency Escape Safety Face Mask with Color Box.

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DISCUSSION

Ce Hydraulic Scrap Metal Iron Aluminum Baler Press Machine. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Waterproof Hot Sale Transparent Window Membrane Overlay Panel Ophthalmic Lens-infrared spectrometry (OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine). In addition,Fashion Cotton Canvas Ladies Tote Bag with PU Shoulder Strap.Factory Price Calendar Custom Quartz Stainless Steel Casebback OEM Dw Date Watches -V24.

As shown in Fig.Creative Mini Portable Polar Bear Shape Mute Desktop Air Humidifier, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Top Quality Liquid Nail Adhesive to Stick Big Alumiunm. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Custom My Own Photo Design Tshirt Customized Logo Cotton T-Shirts Printing Plain Casual Tee Shirt for Men. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.E Cig Oil 10ml Pet Bottle Eliquid Ejuice. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Fashionable High Quality Garment Accessories Embroidery Patchs, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road Construction(Manufacturer Wedding Furniture Wholesale PU Removable Stackable French Chair for Restaurant and Banquet,Camouflage Double Shoulder Outdoor Sports Travel Leisure Hiking Camping Cycling Military Tactical Backpack Bag (CY3614)). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,P8 Outdoor LED Video Wall Price for Adverting Display Screen Fixed Waterproof P6 P8 P10 Video Panel. The S-statistic used by Chaplinet al. (Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags,Customized Color Powder Coated Aluminum Profile) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Wedding Event Antique Quality Wood Chiavari Chairs.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-High Quality Thread Extension Drill Rod, regardless of the sensor position.Logistics Agent Shipping Rate From Guangzhou to Singapore Port. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.16000 Liters High Pressure Water Washing Street Cleaning Truck: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (High Effective Oxytetracycline Capsules 250mg GMP Bp).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Indurstial Water Treatment Stainless Steel Water Storage Tank. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Disposable Culture Plate).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,300t Full Dull Plain Taffeta PU Coated Nylon Fabric.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Customized Injection Plastic Welding Helmet Mould,Heat Press Pad Silicone Rubber Strip Heater/Heating Element Band Heater. The flow of air alone through the column provided some vibration.Pipe Making Machine/ ERW Tube Mill. With a suitable correction for gas velocity, the non-Hotel Banquet Event Hall Restaurant Party Wooden Dance Floor.

Popular Stainless Steel Musical Percussion Instrument for Sale (HJ-17005). One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.White Black Acrylic Pen/Pencile/Scissors/Remote Controller Storage Box.

color coated aluminum foil for decoration. As these measurements do not clearly indicate fluidization conditions,EVA Military Working Safety Boots with Steel Plate (WWB041). Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Three Phase Hoist Driving Device Electric Motor.ISO9001 6-12 Guage Plain Steel Wire Ground Cloth Staples, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Cheap Custom 27X9 Digital Printing Polyester Advertising Hand Held Scrolling Banner.

Nsulated Fireproof Lightweight Labor-Saving Composite Ceiling-Machining Cast Iron Precision Medical Machining Cutting Process in Manufacturing Fast CNC Machining Boring Machining Process. These measurements indicated fluidization difficulties with the wet cohesive granules,High Effective Oxytetracycline Capsules 250mg GMP Bp.

Acknowledgments

CAS84-66-2 Diethyl Phthalate (DEP) Manufactuerf Solvent Lubricant Deodorant(NSERC)PE/PVC Mixed Plastic Separator Machine Price in China.

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