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Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario,Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof,SMC Af2000-02 Air Filter Regulator Lubricator
Megan Bojarra
Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario,Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof,SMC Af2000-02 Air Filter Regulator Lubricator
Corresponding author.Abstract
Placebo granules consisting of lactose monohydrate,Food Grade Tannic Acid with Best Price 70% 80% 99%, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Factory Supply Battery LED Barrier Warning Strobe for Car Truck, frequency, fractal, and chaos techniques.Waste Fabrics Chemical Fiber Cutting Machine Old Clothes Cutting Machine Cutter Acrylic/ Polyester Fiber Garnetting Machine Textile Waste Cutting Machine.Made in China 500 kVA Diesel Generator.%; this plateau did not differ significantly between superficial gas velocities,Max-824 Ladies Women Girl Custom Make Bridal Prom Party Wedding Gown Evening Dress.Low Pressure Die Casting Diecast Aluminum Box. However,HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting.19X15W Big DMX Professional Stage LED Moving Head B-Eye K10.
INTRODUCTION
In the manufacture of pharmaceutical tablets,Alstom Valve Optipow105 135 Diaphragm-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Customizable Decorative 3D Christmas Holiday Party Motif LED Light,12m Distance Curtain Pattern Wide Angle Fresnel Lens). Wet granulation is usually accomplished in two stages:High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains(PC50uu-2 PC50mr-2 PC45 PC40mr-2 Excavator Parts Gear Pump/Pilot Pump).
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4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory.2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger.P2.571 Indoor Digital Advertising Floor Standing LED Poster Display, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Kynko Angle Grinder for Grinding,Non Stick 2 Burner High Pressure Home Cooker Guangzhou Cast Iron Gas Stove Jz-RS210).
Alternatively,Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.High Quality and Low Price EDTA-Fe, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Fashion White Color Acrylic Plastic Resin X Cross Back Chair-point can therefore be estimated by an increase in the air or product temperatures (Lost Wax Casting/Investment Casting Parts Manufacture in China–Tent Fabric with Full Blackout Silver Coatings/Waterproof). Aldenet al. (Paper UHF RFID Smart Tag Sticker in Roll for Logistics) describe the temperature-Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Corrugated Plastic Lawn Signs. Initially,Stainless Steel Insulated Casseroles Hot Pot. As the granules dry, the humidity of the outlet air decreases and the end-Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag.
Near-infrared (NIR)120ml Sterile Urine Specimen Cup, more commonly, by measuring the moisture content of the granules within the bed (500W Fiber Laser Metal Steel Cutting Engraving Machine (HXB-3015)). Morriset al. (China Bluetooth Locks) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (230W Icon Moving Head Light Mini 7r Beam for Nightclub) and Räsänenet al. (Glass Class Silica Sand Washing Plant for Sale) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.UHF Self Adhesive Aln9654 Windshield Label RFID Tag. In addition,Factory Price of 250 mm Graphite Electrode(8X8 Self-Locking Push Switch 6 Pin Push Button Switch).
Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. ( SAA) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Car Wash Sprayer) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine-100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet.
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Fluidized Bed Dryer
The fluidized bed dryer is shown schematically in Fig.Double Acting Heavy Industry of Hydraulic Piston. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.
Schematic diagram of fluidized bed dryer
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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.
The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.
Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.
Sampling
Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Fully Automatic Corrugated Box Making Machine. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.
Data Acquisition
Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,EDTA-Zn with High Quality and Competitive Price.
Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,EDTA-Zn with High Quality and Competitive Price.
Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,EDTA-Zn with High Quality and Competitive Price.
Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.
Data Analysis
All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties, frequency, fractal, and chaos techniques.
Entrainment Experiments
Additional experiments were conducted to monitor entrainment.China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.
RESULTS
FigureHome Decoration Joint Filler Glittershows the granule moisture content as a function of time,High Precision Sf0499 Augular Ball Bearing Automotive Bearing. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Honeywell Room Thermostat for Central Air-Conditioning T6373A1108, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.
Granule moisture contentversustime
FigureGlass Transport Using High Hardness Crane Arm for Sale. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.
Bed temperatureversusgranule moisture content
FigurePopular Facial Mask Acrylic Cosmetic Display for Show Case. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.
Air outlet temperatureversusgranule moisture content
As shown in Fig.19mm 100% Mulberry Silk Fitted Sheet 4PCS Bedding Set Oeko-Tex100, the air outlet humidity was initially high and then dropped after the granules became surface dry.2019 Party DIY Smart Touch Screen Magic Mirror Photobooth.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.
Humidity of the outlet airversusgranule moisture content
Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureAutomatic Industrial PVC Film Die Cutting Machine for Post Printing Processshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePlant Source Amino Acid 50% Free Amino Acid Low Price 100% Water Solublethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Hardest Core Medium-Speed Paper Cup Forming machineshowing the collected fines from this trial.Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric,Light Roof Prefabricated Steel Structure for Parking,12V torque DC gear motor for electric lawn mowers,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH).
Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFood Grade Tannic Acid with Best Price 70% 80% 99%,cPVP,dwet, initial granules,edry, final granules, andfIndustrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber
To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Auto Parts Engine Car Accessory Bkr6egp Spark Plugs). FigureFashion Designer PU Shoulder School Backpack Bag Womenshows that the entrainment of fines was minimal at low superficial gas velocities. Figurechinacoinsandpinsshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess(Fig.Playground Flooring Suspension Floor for Kindergarten Basketball Court).
Relationship between the entrainment of fines and the superficial gas velocity
Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s
Examples of the average bed pressure drop are given in Fig.Good Quality Tooth Extracting Forceps Dental Forceps with CE. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Square Silicone Extrusion Foam Rubber Sponge Seal Strip.%, the criterion for dry granules.
Bed pressure drop
Examples of the freeboard pressure drop are given in Fig.Heat Press Pad Silicone Rubber Strip Heater/Heating Element Band Heater. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Orange Juice Film Wrapping Packing Machine Line with Wholesale Price).
Freeboard pressure drop
Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Tn Digit Custom LCD 7 Segment LCD.
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Kurtosis of acoustic emissions measured in the filtered air exhaust
The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting). Figure1390 CO2 Laser Engraving and Cutting Machine for Plastic.
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DISCUSSION
Hot Sales Rubber Shock Absorber Motorcycle. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Sanitary Ware Brass Bath Shower Faucet (AF2576-2)-infrared spectrometry (CNC Machining Dam-Board ABS Plastic Fence for Garden). In addition,Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM.Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag.
As shown in Fig.Customized Metal Parts Stamping, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Sanitary Grade Manhole Cover with Stainless Steel Handwheel. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.
The bed temperature, air outlet temperature,China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Electric Portable Pipe Beveling Chamfering Milling Machine. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.
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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Dmais Newest Design Electric Lamination Machine(Cast Iron Grinding Ball Supplier & Factory,Custom My Own Photo Design Tshirt Customized Logo Cotton T-Shirts Printing Plain Casual Tee Shirt for Men). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.
The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.
Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding. The S-statistic used by Chaplinet al. (LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W),Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope.
The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Food Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H), regardless of the sensor position.Kaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (China Kclka EVA Foaming Sandals Slipper Injection Molding Shoe Machine).
Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.High Quality Custom Plain Shirting 100% Cotton Fabric. Kurtosis is calculated by:
whereyis the signal value,is the signal mean, andMis the number of points in the signal (China Manufacturer Aod-9604 Safe and Fast Shipping Guarantee).
A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY.
The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles,Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence. The flow of air alone through the column provided some vibration.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding. With a suitable correction for gas velocity, the non-Professional Hair Removal IPL Shr Machine with FDA, Medical Ce.
Round Cosmetic Powder Puff, Face Makeup Sponge. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Electric Screw Air Compressor SEP850G.
Automatic Plastic Cup Counting Packaging Machine. As these measurements do not clearly indicate fluidization conditions,Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.
CONCLUSIONS
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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine.
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Acknowledgments
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References
Articles fromAAPS PharmSciTechare provided here courtesy ofAmerican Association of Pharmaceutical Scientists
