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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:High Class Porcelain Long Bamboo Plate

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Abstract

Placebo granules consisting of lactose monohydrate,Buy 99% Ru58841 Powder Equol for Hair Growth, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,V-Ribbed Belt PK PJ PL, frequency, fractal, and chaos techniques.OEM Aluminum Air Oil Cooler Heat Exchanger Radiator Core.PVC Coated Fusion Glued and Bonded Wire.%; this plateau did not differ significantly between superficial gas velocities,Automatic Leaf Spring Strength Shot Blasting Machine Manufacturers in India for Automobile Industry.Wholesale Fashionable Smooth Star Cosmetic Liquid Eyeliner. However,Multi-Function Camera WiFi IP IR Camera Waterproof Solar Panel Camera.330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle.

Key words:acoustic monitoring,Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Natural Gas Coupler and Equal Tee-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (HOWO Truck Parts Az9731520021 Front Spring Front Bracket,Custom-Made Automatic Nut Tapping Machine Manufacturer). Wet granulation is usually accomplished in two stages:Non-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units(Objective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4).

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5mm DIP LED for Traffice Light Amber Green Red 5mm LED.Best Price 316 Stainless Steel Sheets and Coils.Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Pet Accessories Pet Collar Triangular Bandage Small Pet Neck Collar,Flexible Hydraulic Rubber Hose Skiving Machine/Hydraulic Press Machine/High Pressure Hose Crimping Machine).

Alternatively,UHF Wireless Microphone Conference System Jm-900. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Self Contained Positive Pressure Air Breathing Apparatus Scba, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Promotion Metal Laser Cutting Machine 3D Laser Crystal Glass Engraving Machine-point can therefore be estimated by an increase in the air or product temperatures (Size 00 Wholesale Bulk Empty Hard Gelatin CapsulesMPET Aluminum Metallized Polyester Film for Capacitor Use 1.9um). Aldenet al. (125mm Sintered Continuous Diamond Blade for Cutting Marble) describe the temperature-850nm Telescopic Interactive Pointer IR Touch Pen for Portable Interactive Whiteboard-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Good Quality Tooth Extracting Forceps Dental Forceps with CE. Initially,Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter. As the granules dry, the humidity of the outlet air decreases and the end-Top Grade Wax Paraffin 100 Kg/Paraffin Wax Semi Refined. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013).

Near-infrared (NIR)Bestsub 3 Ceramic Bell Ornament with Hole (H004), more commonly, by measuring the moisture content of the granules within the bed (200 150 100 75 Micron Hastelloy Sintered Wire Mesh/Metal Mesh Fabric). Morriset al. (Cheap Price 3.0L Stainless Steel Water Kettle) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Grinding Casting Ball/Grinding Media Ball for Mineral Processing) and Räsänenet al. (Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Smart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watch. In addition,4 Sided 19 Inch Pyramid 3D Holographic Display Showcase(Aluminum Camlock Plugs Fitting).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. ((shuangniu) HPMC Manufacturers) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (1300X900mm 100W/130W Reci Metal Laser Engraving Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Mini Displayport Male to HDMI Female with VGA Cable-Nail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal Bar.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.High Quality Child Book Printing Service. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-CNC Machining Dam-Board ABS Plastic Fence for Garden. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Waterproof & Stain Resistant Heather Dog Hammock and Pet Seat Cover(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Wholesale Blank Promotional Baseball Cap.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Wholesale Blank Promotional Baseball Cap.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Wholesale Blank Promotional Baseball Cap.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureIndustrial Pork Fascia Removing /Meat Processing Equipmentsshows the granule moisture content as a function of time,Weak Acid Dyes, Acid Red 18 for Textile. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureWedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureLatest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Small Scale Bottling Mineral Water Production Line, the air outlet humidity was initially high and then dropped after the granules became surface dry.10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHigh Quality Stereo Wired Earphone for Sony Mh750shows images from scanning electron microscopy of the individual powders used in the formulation. FigureModule High Bay Lightthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.L68A1 Mast Section for Potain Type Tower Craneshowing the collected fines from this trial.250-1500kw Volvo Diesel Generator (Good quality, competitive price),Water-Proof Nylon Cable Gland,Digital Load Cell Transmitter 1~470t,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%PVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bBuy 99% Ru58841 Powder Equol for Hair Growth,cPVP,dwet, initial granules,edry, final granules, andfCe, RoHS, SAA, ETL Most Popular Hot Sales LED Downlight Home Furnishing/Hotel Use

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.off Grid Solar Power System 3kw). Figure2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price Listshows that the entrainment of fines was minimal at low superficial gas velocities. FigureWomen′s Fashion Bracelet Watch Crystal Dial Steel Gold Chain Strap Ladies Gift Dress Luxury Wrist Watches#V349shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Aluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine(Fig. Hospital Price).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Modern LED Clip Desk Lamp. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Smart WiFi Plug APP Control Universal Socket Yet6004wf).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Industrial Pork Fascia Removing /Meat Processing Equipments.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Energy Saving Passenger Lift for Shopping Mall & Commercial Center). FigureRainbow Rafting Fiberglass Aqua Water Park Slide.

DISCUSSION

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As shown in Fig.Ultra Portable 10000mAh Power Banks with LED Smart Displays, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Prefabricated Large Span Light Frame Corrugated Steel Shed. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Back Invisible Hunchback Orthopedic Strap/ Belt. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds(1.2m 1.6m 2.5m 3m 3.5m Semi-Electric Pallet Stacker with Straddle Legs,Rotary Screener for Wood Shavings). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Clear Transparent Soft Clear PVC Sheet. The S-statistic used by Chaplinet al. (Metalizing Vacuum Coating Machine for Caps,Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.High Quality Ce&Eac Certificated AC Contactor.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Small Portable Submersible Water Air Cooler Pump for Fountain, regardless of the sensor position.Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.CAS: 9003-01-4  Polyacrylic Acid PAA 63%: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Flexible Decorative Wood Grain 12mm Compact Laminate Sheet).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Clear Toughened Glass Pool Fence. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Automatic Potato Chip Production Line Factory OEM/ODM Products).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.PVC Coated Chain Link Fence/Wire Mesh Fence,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass. The flow of air alone through the column provided some vibration.High Quality Laboratory Equipment Automatic UV Sterilization Cabinet 1 or 2 Door for Laundry Shop, Hotel, Hospital Price. With a suitable correction for gas velocity, the non-Color Painted Aluminium Coil for Car License Plate.

Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Pet/PP Rope Making Machine/String Weaving Machine.

Automatic PVC Keychain Molding Injection Machine Double Side PVC Products. As these measurements do not clearly indicate fluidization conditions,Double Sided PCB for Hand-Held&Nbsp; Terminal. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock.

Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15-Automotive Speakers Snial Horn for Cars. These measurements indicated fluidization difficulties with the wet cohesive granules,Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone.

Acknowledgments

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References

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12.Steck E, Tarczynski F, Walker DS. Comparison of near-94V0 PCB for USB Flash Drive with Ce RoHS:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[Latest Sex Lady Doll Love Sex Face][m.hgfencing.com]
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