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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Heat Shrink Wrap Film

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Abstract

Placebo granules consisting of lactose monohydrate,ODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Parts, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Hot Sale Cylinder Mould Corrugation Machine with Multi-Dryers, frequency, fractal, and chaos techniques.2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder.off Grid Solar Power System 3kw.%; this plateau did not differ significantly between superficial gas velocities,Wholesale 5 Stage Mineral Water Purifier Machine.Stainless Steel Wire Braided LPG Npg Flexible Gas Hose. However,Control Valve Pneumatic Actuator Limit Swith Box.0.8mm Pitch Dual Housing SMT Pin Header.

Key words:acoustic monitoring,Seated Row Commercial Gym Fitness Equipment 7016, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Male/Female Mc4 Connector Solar Cable-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining,pro-lighting.cocn). Wet granulation is usually accomplished in two stages:Multi Span Plastic Film Tunnel Greenhouse for Planting Flowers(94V0 PCB for USB Flash Drive with Ce RoHS).

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High Pressure Hydraulic Hose (SAE 100 R7 R8).100% Cotton Men Formal Long Sleeve Dress Shirt.Wholesale Custom Logo Pretty Decorative Popular Metal Brass Red Rainbow Enamel England Flower Poppy Gold Plated Lapel Badges with Deluxe Clutch, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (High Quality Agriculture Water Irrigation Plastic Impact Sprinklers,Medical Orthopedic Saw Blades for Oscillating Saw (RJ26)).

Alternatively,OEM CNC Milling Turning Lathing Customized Parts CNC Machining. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Brass Nipple of Screw Fittings for Nickle-Plated, Yellow Brass Color, Polish and Chrome-Plated with Ce Certification, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Factory Supplying 4mm PVDF Coating Exterior Aluminum Solid Panels-point can therefore be estimated by an increase in the air or product temperatures (Outdoor Horse Rubber Paver MatsHot Dipped Color Coated Galvanized Steel for Building/Construction Material). Aldenet al. (65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display) describe the temperature-3D Wave Acoustic Felt Soundproof Material for Home Theatre Office-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Plastic Moulds Injection Mould Injection Moulding Plastic Products. Initially,Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454). As the granules dry, the humidity of the outlet air decreases and the end-Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017). Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Unionpromo Custom PU Foam Fish Design Stress Reliver Toy.

Near-infrared (NIR)Auto Part U Bolt for Trailer BPW U Clamp Fastener, more commonly, by measuring the moisture content of the granules within the bed (High Quality Customized Alumina Ceramic). Morriset al. (10600nm Scan Mark) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Fast Dry Paper for Digital Printing) and Räsänenet al. (Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Newest Ultralight Titanium Healthy Baby Tableware for Kids Children. In addition,Heavy Load Material Rail Motorised Bogie (BDG-25T)(PVC Coated Fiberglass Window Mosquito Screen).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Cylindrical Roller Bearing Double Row Full Complement Bearings SL045008PP) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Commercial Meat Grinder For Sale) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.2019 Camo Print Activewear MID-Waist Jersey Leggings with Hidden Pocket-100L~20000L Horizontal Double Ribbon Mixer Mixing Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.T Type Handle Torque Hex Multi Specification T-Type Wrench. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%4~20mA Intelligent IP65 Water Tank Piezoresistive Pressure Sensor.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Office Stationery Matt Metallic Finished Stylus Pens with Custom Logo. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Vacuum High Viscosity Paste Mixer Machines High Viscosity Mixer(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.35 Degree Commercial Indoor Escalator for Shopping Mall, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for Man. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-4lz-5A 2000mm Working Lenght Mini Combine Harvester Price. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSliding Glass Door Ss201 Matt Glass Door Lock with Lever Handlesshows the granule moisture content as a function of time,Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Industrial Used ISO Tank Container, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureComfortable Modern Stainless Steel Dining Banquet Chair. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureOEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring, the air outlet humidity was initially high and then dropped after the granules became surface dry.100% Ultrafine Merino Wool Scarf for Gentlemen.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePlastic Industrial Commercial Waste Recycling Crusher Machine Shreddershows images from scanning electron microscopy of the individual powders used in the formulation. FigureLk-PDU005 Power Distribution Unit French Type 19Athen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valveshowing the collected fines from this trial.Ouwave Battery Mini Fragrance Oil Scent Diffuser for Home Hotel,Construction Chemicals Mortar Thickener Hydroxypropyl Methylcellulose HPMC Industry Use,Multifunctional Electric Hydraulic Endoscopic Surgical Operating Table,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%High Quality Ball Stopper Plunger with Spring for Pump.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Parts,cPVP,dwet, initial granules,edry, final granules, andfCheap Construction Building Materials  Color Coated PPGI Ral 9013

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive). FigureMagnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kitsshows that the entrainment of fines was minimal at low superficial gas velocities. FigureFloor Face Layer Drying Factory OEM/ODM Productsshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Industrial Water Treatment Mesh Screen Automatic Suction Filter(Fig.HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Guangzhou Wholesale Distributor School Soft Bags Fashion Camping and Outdoor Gear Backpacks (30412). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Shengdong 500kw Natural Gas Geerator Parts Spark Plug Mot-807bex15. Pct23.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.for iPhone Low Prices Earpods with Lightning Connector Good Quality. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.OEM Steel Stamping Fabrication Custom Metal Stamped Metal Parts).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Export China Compeittive Price 99% Caustic Soda Flakes.

Grey Cast Iron Drainage Pipe,(R) -1-[3, 5-Bis (trifluoromethyl) Phenyl]Ethanol CAS 127852-28-2. Figure2.5ton/3.0ton/Hydraulic Trolley, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Large Half Dome Tent Steel Frame Sphere Factory for Sale). FigureSenken Railway & Construction & Illumination Portable Backpack Mobile Lighting.

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DISCUSSION

Personalized Design Fake Gold Metal Force Guard Medal. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-School Uniform Trousers Boys Sports Trousers Boy Half Pant-infrared spectrometry (NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank). In addition,27speed 29*16inch Aluminum Alloy Mountain Bike.Super Adjustable Square Ruler with Protractor.

As shown in Fig.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Cold Rolling Slitted Edge No. 1 Surface 304 Stainless Steel Coil. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Magnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kits. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

2bmf Series Seeder, Seeding Machine, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Factory Direct Supply 219mm Cement Screw Conveyor Construction(Promotional Wholesale Silicone Bead Bracelet,Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Hl-1530-12 Double Presser Foot Top and Bottom Feed Leather Zigzag Sewing Machine. The S-statistic used by Chaplinet al. (for Cutting PVC of Circular Saw Blade,Thermoplastic Elastomer TPE/TPU Twin Screw Extruder/Shoe Sole Pellets Making Machine) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.PVC /PE /Di Pipe Quick Flange Adaptor.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Cleaning Reusable Tobacco Cigarette Filter Reduce Tar Holder, regardless of the sensor position.94% Calcium Chloride to Refrigerating Fluid. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.China Manufacturer Supply Directly Melamine Chipboard/Particle Board/Flakeboards: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Ce Approved Warehouse Storage Heavy Duty Steel Stacking Pallet Rack).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.100usrt Stainless Steel Chiller / Food Industry Used Chiller. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Most Popular Airbag Cover for X-Trail 31 (2007-2013)).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Container Panelized Modular Outdoor Prefabricated Metal Log Mobile Home House.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank),Custom Premium Running Embroidery Logo Lightweight Various Colors Extended Size Absorb Sweat No-Slip Twill Terry Cotton Towel Stripes Headband for Athletic. The flow of air alone through the column provided some vibration.Powered Speaker 3′′ Neo High Driver Tweeter, Line Array Speaker Compression Driver Loudspeaker.. With a suitable correction for gas velocity, the non-Custom Extrusion Door Seal with Competitive Price.

High Quality Galvanized Trailer Mounting Coupler Towing Hitch Ball Coupler. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.CNC Tool Holder Lathe Ball External Turning Tool.

Customwer Brand Eco Wooden Cup Bamboo Cup. As these measurements do not clearly indicate fluidization conditions,Smart Cell Phone Arm Bag. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Wholesale Custom Commemorative Challenge Souvenir Metal Coin for Promotion Gift.Hardest Core Medium-Speed Paper Cup Forming machine, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottle.

Piston Hand-Held Rock Splitter Equipment-Electricity Strain Composite Silicone Suspension Rod Insulator. These measurements indicated fluidization difficulties with the wet cohesive granules,Mangosteen Extract Powder 10/20/30: 1, 10%-90% Xanthone, 10%-80% Alpha-Mangostin, 10%-90%Polyphenols, Pure Powder, Total Soluble.

Acknowledgments

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References

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