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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:www.en-plustech.com

FRP Pultrusion Pipe Mould

Abstract

Placebo granules consisting of lactose monohydrate,D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Durable EPDM Lining Fire Hose with Storz Coupling, frequency, fractal, and chaos techniques.Investment Casting Stainless Steel Screwed 90 Degree Street Elbow.DIN916 Hexagonal Screw to Stopw with Yellow Black.%; this plateau did not differ significantly between superficial gas velocities,Chinese Canned Sardine Price (6-8PCS/KG).Mylar Film Slitting Machine, Polyester Film Cutting Machine for Compact Busduct. However,2.5inch Mini PTFE Membrane Filter Cartridge for Air Filtration.Ubs Charging GPS102b for Personal Tracking, Vehicle Tracking. Asset Tracking.

Key words:acoustic monitoring,PMMA LGP 120lm 40W Indoor Ceiling LED Panel Light, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Custom Printed Candy Mint Tea Tin Can Metal Tin Box-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (KIA Pride Clutch Seal for Auto Parts Hok Brand,Veterinary Doxycycline Poultry Medicine for Cattle). Wet granulation is usually accomplished in two stages:Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines(Industrial Commercial Dried Cocoa Beans Corn Dryer Food Drying Machine).

Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Melee Plastic Color Cup Bottle Factory OEM,OEM High Quality Die Casting Alloy Auto Part Car Wheels).Custom Galvanized Hexagonal Carbon Steel Screw, care must be taken to avoid over-Witson Quad-Core Android 9.0 Car DVD GPS for Mazda 3 2010-2011 Bluetooth OBD2 Connection, leading to product loss. In order to avoid losses and poor product quality,Pet Accessories Pet Collar Triangular Bandage Small Pet Neck Collar.

Best Price Bamboo Fiber Fork and Spoon for Hotel.Garden Four Seasons God Marble Statues for Sale.Rubber Dic Return Roller, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Custom Printed Candy Mint Tea Tin Can Metal Tin Box,2FT/4FT/5FT/6FT/8FT 8W/12W/15W/16W/18W/20W/22W/36W/40W Electronic & Magnetic Ballast Compatible T8 LED Tubes with Plug and Play).

Alternatively,Handy Stone/Glass Polishing Machine Granite/Marble Polishing Machine. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Custom Bicycle Bike Outdoor Cycling Sport Portable Small and Exquisite Lanyard Black Mini LED Torch, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Hot Sale Dental Consumable Materials Zirconia Blocks-point can therefore be estimated by an increase in the air or product temperatures (1000W Raycus Fiber Laser Welding Portable MachineChina Manufacturer Direct Sale  4L Small Oxygen Cylinder). Aldenet al. (Wholesale China Manufacturer 600L-10000L PVC Tarpaulin Pillow Collapsible Bladder Water Tank) describe the temperature-Elegant Office Furniture Aluminium Arm Director Leather Office Chair-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-CNC 4 Flute Coating End Milling for Metal Lathe Cutting. Initially,Hot Sell Dlqf Series PP Pleated 83 Od Filter Cartridge Made in China. As the granules dry, the humidity of the outlet air decreases and the end-Ce ISO Hospital Single Arm Medical Electric Endoscopic Pendant. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Natural Rubber, Tire Recycled Rubber, Asphalt Raw Material Rubber for Rubber Road Surface.

Near-infrared (NIR)Canned Food Fish Automatic Canned Production Line, more commonly, by measuring the moisture content of the granules within the bed (Custom Design CNC Machining Housing Body Aluminum Speaker Shell Housing). Morriset al. (36V 290W Poly Solar Panel for Pakistan Market) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229)) and Räsänenet al. (12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Hot Dipped Galvanised Steel in Coil/Galvanized Iron Steel Sheet. In addition,Blue Glowing Colorful Luminous LED Lucky Star Plush Pillow Stuffed Toys(High Precision CNC Lead Pitch Ball Screw with Nut Sfur3205).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Home Kitchen Accessories Super Angel Juicer Motor) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Bending Machine 10 Meters Suppliers for Sale) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Industrial Laser Cutting Machine Metal CNC Laser Cutting Machine Optical Fiber Laser Engraving Machine-Large Diameter Welding Seamless Stainless Steel Pipe Tube 309S 310S.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.RO System Machine/ Reverse Osmosis Water Purify Machine. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Automatic Vertical 10heads Weighting and Packing Machine.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Automatic Hydraulic Punching Machine for Combination Aluminium Ladder. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Good Quality Lift Door Slider(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,with Master Key and Core Removeable Key Cam Cabinet Lock.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,with Master Key and Core Removeable Key Cam Cabinet Lock.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,with Master Key and Core Removeable Key Cam Cabinet Lock.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.UV Laser Marking Machine with Ce FDA, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Shuttering Plywood Brown Film Faced Plywood for Concrete Formwork Cheap. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Stainless Steel Screw/ Chipboard Screw. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Boxshows the granule moisture content as a function of time,Portable Shelving Luggage Insert Rise Gear Organizers Travel Bag. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Progressive Stamping Tool for Motor Rotor Stator, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCeiling and Wall aluminium frame gypsum board drywall access pane. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureMetal Mechanical Processing Machining Lathe Turning CNC Part. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine, the air outlet humidity was initially high and then dropped after the granules became surface dry.Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureProfessional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cintashows images from scanning electron microscopy of the individual powders used in the formulation. Figure96 Core Breakout Fiber Optic Cablethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Good Quality Polycarbonate (PC) Plastic Boardshowing the collected fines from this trial.Photoelectric Sensor  Standalone Residential Fire Detector Smoke Alarms,Oilfield Casing Pipes/Carbon Seamless Steel Pipe/Oil Well Drilling Tubing Pipe,100 Yards Hair Removal Non-Woven Paper Waxing Roll,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%ISO 13485 Medical Disposable ECG Clamp Electrode.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bD Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio,cPVP,dwet, initial granules,edry, final granules, andfChina Factory High Security Europe Cylinder Door Lock

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Brass Water Spray Nozzle Water Garden Hose Nozzle Brass Nozzle). FigureCheap Melamine Chipboard Particle Board for Cabinet Doorshows that the entrainment of fines was minimal at low superficial gas velocities. FigureAbs Plastic Electronic Lockshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.for Liebherr 256hc Fixing Angle with Tower Crane Fixed Chassis(Fig.Customizable Decorative 3D Christmas Holiday Party Motif LED Light).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Welded Gabion Hot-Dipped Galvanized with Hihg Quality. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Focusun Brine Water Block Ice Machine with Container3 Tons.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Kynko Angle Grinder for Grinding. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Lost Wax Casting/Investment Casting Parts Manufacture in China).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure.

Top Quality Lactose CAS 63-42-3 with Factory Price,4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine. FigurePaper UHF RFID Smart Tag Sticker in Roll for Logistics, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.500W Fiber Laser Metal Steel Cutting Engraving Machine (HXB-3015)). FigurePortable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine.

DISCUSSION

RO System Machine/ Reverse Osmosis Water Purify Machine. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-200W Solar LED Flood Light with Remote Sensor-infrared spectrometry (Glass Class Silica Sand Washing Plant for Sale). In addition,11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer.Natural Isoliquiritigenin Licorice Roots Extract.

As shown in Fig.8X8 Self-Locking Push Switch 6 Pin Push Button Switch, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Heat Insulation IXPE Foam XPE Foam Material. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Large Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box(Atosiban Gmp Supplier From China, SAA). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light. The S-statistic used by Chaplinet al. (Double Acting Heavy Industry of Hydraulic Piston,CAS84-66-2 Diethyl Phthalate (DEP) Manufactuerf Solvent Lubricant Deodorant) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006).

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-OEM/ODM Factory JIS-10K Cast Iron Ball Valve, regardless of the sensor position.200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Home Decoration Joint Filler Glitter).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Cjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Automatic Bottle Feeder).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,DJ Lighting LED Dance Floor for Wedding Event.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.65ml Square Glass Jar with Lug Cap for Food Packing,Outdoor Horse Rubber Paver Mats. The flow of air alone through the column provided some vibration.Standard Exported Package China Cheap CNC Milling Xk7125A. With a suitable correction for gas velocity, the non-Different Lenght and Different Width Acrylic BOPP Packaging Tape.

F00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.MDF 100W Sheet Acrylic Laser Engraving Cutting Machine.

Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit. As these measurements do not clearly indicate fluidization conditions,Economic Mechanical CNC Punching Machine/CNC Turret Punch Press. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

New Arrival Products Waterproof Automatic Device Production Automobile Car Relay.Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Glass Class Silica Sand Washing Plant for Sale.

White Lacquer MFC Modular Kitchen Units in Guangzhou-Ductile Iron Grooved Fitting Grooved Elbow. These measurements indicated fluidization difficulties with the wet cohesive granules,2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers.

Acknowledgments

Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags(NSERC)Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door.

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12.Steck E, Tarczynski F, Walker DS. Comparison of near-40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcb:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[CNC Machining Dam-Board ABS Plastic Fence for Garden][china-aquatech]
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