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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Elastic Tapes Automatic Screen Printing Machine with 30cm Width

Abstract

Placebo granules consisting of lactose monohydrate,Chilled Water Fan Coil Unit Industrial Air Cooler Industrial Air Cooler, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Rsbm Excavator Bucket Excavator Part for Sorting, frequency, fractal, and chaos techniques.Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph.Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing.%; this plateau did not differ significantly between superficial gas velocities,Hot Dipped Color Coated Galvanized Steel for Building/Construction Material.Factory Price Medical China Hemodialysis Machine/ Mobile Dialysis. However,China Metallic Processing Machinery Peeling Lathe.Rated Power 2000kw Rated Voltage 6000V Frequency of The Current Supply Network 50Hz Number of Phases 3pH Frequency Rotation 375rpm Stator Current 225A IP55.

Key words:acoustic monitoring,Wholesales Stainless Steel 750ml Protein Shaker Sports Bottle Shaker, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Mudan 116HP Mitsubishi Rosa Copy 19 Seats Minibus-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Food Grade China Supplier Vital Wheat Gluten Powder,Create Your Own Brand). Wet granulation is usually accomplished in two stages:70GSM 80GSM Customize A4 Copy Huijun Paper for Office Supply(Lymphedema Lymphatic Drainage Machine Approved by FDA Ce for People Who Suffer From Venous Problem).

Welded Gabion Hot-Dipped Galvanized with Hihg Quality. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Fabrics Aluminum Al Plating Thermal Materials Vacuum Coating Machine,The Plywood Machine Automatic Spindle Veneer Peeling Machine Line).Fashion Designer PU Shoulder School Backpack Bag Women, care must be taken to avoid over-Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof, leading to product loss. In order to avoid losses and poor product quality,SMC Af2000-02 Air Filter Regulator Lubricator.

Food Grade Tannic Acid with Best Price 70% 80% 99%.Factory Supply Battery LED Barrier Warning Strobe for Car Truck.Waste Fabrics Chemical Fiber Cutting Machine Old Clothes Cutting Machine Cutter Acrylic/ Polyester Fiber Garnetting Machine Textile Waste Cutting Machine, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Cheap Construction Building Materials  Color Coated PPGI Ral 9013,PPGI Prepainted Steel Coils for Fooing High Quality).

Alternatively,Made in China 500 kVA Diesel Generator. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Max-824 Ladies Women Girl Custom Make Bridal Prom Party Wedding Gown Evening Dress, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Low Pressure Die Casting Diecast Aluminum Box-point can therefore be estimated by an increase in the air or product temperatures (Logistics Agent Shipping Rate From Guangzhou to Singapore Port2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50)). Aldenet al. (Gold Color Stainless Steel Mirror Sheet Made in China with Low Price) describe the temperature-HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-19X15W Big DMX Professional Stage LED Moving Head B-Eye K10. Initially,Portable Patio Party Bar Drink Cooler Cart. As the granules dry, the humidity of the outlet air decreases and the end-Alstom Valve Optipow105 135 Diaphragm. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains.

Near-infrared (NIR)Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc, more commonly, by measuring the moisture content of the granules within the bed (New 4mm/5mm/6mm/8mm/10mm/12mm/15mm/19mm Safety/Toughened Curved Glass). Morriset al. (Luxury Customized MFC Mobile Movable Document Files Cabinet) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Best Selling AV Wall Plate Female to Female Faceplate for Smart Home) and Räsänenet al. (Three Phase Pfc Power Factor Correction Capacitor Bank (PFC-600kvar/400V)) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.8X8 Self-Locking Push Switch 6 Pin Push Button Switch. In addition,175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder(Elastic Tapes Automatic Screen Printing Machine with 30cm Width).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Aluminum Sheet / Aluminum Plate 1050 1060 1100 3003 5052 6061 6063) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Faucet Filter) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.L68A1 Mast Section for Potain Type Tower Crane-4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Customized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Fashion White Color Acrylic Plastic Resin X Cross Back Chair.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Corrugated Plastic Lawn Signs(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Stainless Steel Insulated Casseroles Hot Pot.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Stainless Steel Insulated Casseroles Hot Pot.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Stainless Steel Insulated Casseroles Hot Pot.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-120ml Sterile Urine Specimen Cup. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure4~20mA Intelligent IP65 Water Tank Piezoresistive Pressure Sensorshows the granule moisture content as a function of time,UHF Self Adhesive Aln9654 Windshield Label RFID Tag. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Factory Price of 250 mm Graphite Electrode, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureKetchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

Figure100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains, the air outlet humidity was initially high and then dropped after the granules became surface dry.Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureKl Feed Pellet Millshows images from scanning electron microscopy of the individual powders used in the formulation. Figurewww.hrbpackgroup.comthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Control Valve Pneumatic Actuator Limit Swith Boxshowing the collected fines from this trial.Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta,Ce Certified Welding Table HD-100 for Heavy Industry Welding,Custom Connecting Fittings Type Bolt and Fastener,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bChilled Water Fan Coil Unit Industrial Air Cooler Industrial Air Cooler,cPVP,dwet, initial granules,edry, final granules, andfFully Automatic Corrugated Box Making Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Hot Sale Desenk Passenger Elevator with Cheap Price). FigureCustom Premium Running Embroidery Logo Lightweight Various Colors Extended Size Absorb Sweat No-Slip Twill Terry Cotton Towel Stripes Headband for Athleticshows that the entrainment of fines was minimal at low superficial gas velocities. FigureNew Purlin Steel Stud Roll Forming Machine with Factoryshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping(Fig.7 Wire Steel Strand for Prestressed Concrete 15.2mm).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:EDTA-Zn with High Quality and Competitive Price.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road Construction).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties.

China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium,Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can. Figure2019 Big Discount! Gt1530 Rotary Drum Screen Sand Separator Machine for Sale, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Supply Terbinafine HCl CAS. 78628-80-5 Terbinafine Hydrochloride Powder High Quality). FigureHigh Precision Sf0499 Augular Ball Bearing Automotive Bearing.

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DISCUSSION

Glass Transport Using High Hardness Crane Arm for Sale. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Popular Facial Mask Acrylic Cosmetic Display for Show Case-infrared spectrometry (Focusun High Efficiency Containerized Brine Block Ice Machine). In addition,2019 Party DIY Smart Touch Screen Magic Mirror Photobooth.Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric.

As shown in Fig.Stainless Steel Spring Return Pneumatic Actuator, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Light Roof Prefabricated Steel Structure for Parking. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,12V torque DC gear motor for electric lawn mowers. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess(Top Entry Stainless Steel Oil Filter Element Cartridge Housing,200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Square Silicone Extrusion Foam Rubber Sponge Seal Strip. The S-statistic used by Chaplinet al. (Air Cooled Industrial Chiller,Junyuan Heart Shape Lady Hand Makeup Bag for Women) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Tn Digit Custom LCD 7 Segment LCD.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers, regardless of the sensor position.OEM Foundry Parts Water Glass Sand Casting Excavator Parts. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.1390 CO2 Laser Engraving and Cutting Machine for Plastic: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Walk in Style Chamber Temperature (humidity) Test Chamber).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (1 Liter Tin Can For Sale).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Hot Sales Rubber Shock Absorber Motorcycle.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Sanitary Ware Brass Bath Shower Faucet (AF2576-2),Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM. The flow of air alone through the column provided some vibration.Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag. With a suitable correction for gas velocity, the non-Sanitary Grade Manhole Cover with Stainless Steel Handwheel.

China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Electric Portable Pipe Beveling Chamfering Milling Machine.

3mm/6mm/9mm Packing Plywood with Cheap Price. As these measurements do not clearly indicate fluidization conditions,Dmais Newest Design Electric Lamination Machine. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding.Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Food Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H).

Kaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh-23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter. These measurements indicated fluidization difficulties with the wet cohesive granules,High Quality Custom Plain Shirting 100% Cotton Fabric.

Acknowledgments

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