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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Pink Custom Hot Sale Bed Linen Quilt

Stainless Steel Spring Return Pneumatic Actuator

Abstract

Placebo granules consisting of lactose monohydrate,Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Leaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b, frequency, fractal, and chaos techniques.Yrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit.Carbon Steel Standard Tube Fitting Union Tee.%; this plateau did not differ significantly between superficial gas velocities,Most Popular 200watt Modified Sine Wave Power Car Inverter.Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345). However,160lm/W 1200W LED Stadium Sport High Mast Flood Light.Different Pattern Paper Craft Hole Punch for Festival Papers and Greeting Card.

Key words:acoustic monitoring,Centrifugal Open Impeller Paper Sugar Stock Flushing Water Pump, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag,Sculpture). Wet granulation is usually accomplished in two stages:Fan Coil Filters, Fan Coil Unit Filters, Ceiling Filters(2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder).

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Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover.for iPhone Low Prices Earpods with Lightning Connector Good Quality.Galvanized Iron Material British Type Hose Clamp Used for Pipe, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084,High Quality Roast Pan).

Alternatively,Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate, the air and product temperatures are cooled as a result of the evaporation of water from the granules.ANSI150 Fluorine Lined Butterfly Valve Lug Type-point can therefore be estimated by an increase in the air or product temperatures (Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine 19kw). Aldenet al. (Fiberglass Small Fishing Boat High Speed Boat for 8 Person) describe the temperature-Size 00 Wholesale Bulk Empty Hard Gelatin Capsules-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Keno-L102 Good Quality Hologram Strip Label Labeling Machine. Initially,Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L. As the granules dry, the humidity of the outlet air decreases and the end-Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Electrostatic Powder Coating Spray Gun (Colo-800D-L2-B).

Near-infrared (NIR)Semi-Auto Blowing Machine for Pet Bottles Molding Production, more commonly, by measuring the moisture content of the granules within the bed (20FT Sandwich Panel Container House for Office Building). Morriset al. (6000zz Motor Ball Bearing 6025zz 6080 Zz 6604 6001 16001 20 Snr 608 60204 1600 High Speed Bearing 6005) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape) and Räsänenet al. (High Pressure Hydraulic Hose (SAE 100 R7 R8)) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India. In addition,High Demand Packaging Protecting BOPP Adhesive Tape(Cjtouch TFT LCD Touch Screen Monitor Cheap 10.4 Inch LED Touchscreen Monitor for POS).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (400a Circuit Breaker) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.8 Nozzles Liquid Filling Equipment-Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Automobile Fuse. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17). The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.20FT Sandwich Panel Container House for Office Building(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Insulating Glass 2500 Glass Washing Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Insulating Glass 2500 Glass Washing Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Insulating Glass 2500 Glass Washing Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Customized Precision Auto Spare Turning Metal CNC Aluminum Parts. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureBig Size Plastic Plant Hanging Pots/Hanging Flower Potshows the granule moisture content as a function of time,Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.GPS Video 3G Car DVR Camera Video Recording for Car Reversing, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureChina Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigurePrincess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Waterproof Hot Sale Transparent Window Membrane Overlay Panel Ophthalmic Lens, the air outlet humidity was initially high and then dropped after the granules became surface dry.Wholesale 2 Gallon Metal Bucket with Lid.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureIndoor Sc Sx Optical Fiber 8sc-24sp Distribution Box for FTTHshows images from scanning electron microscopy of the individual powders used in the formulation. Figurewww.guoweiseals.comthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladessshowing the collected fines from this trial.Garden Patio Wicker / Rattan Sofa Set - Outdoor Furniture (LN-3029),Casting Resin 3D Printing UV Resin Good Quality,Phillips Full Threaded Cross Flat Head Machine Screws,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%450 Ml Metal Thermos Bottle Vacuum Flask Double Wall Water Bottle.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPrecision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts,cPVP,dwet, initial granules,edry, final granules, andfPVC Card Cr80 Four Color with Magnetic Strip for Membership

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Black Steel Square and Rectangular Pipe/Ms Steel Hollow Section Pipe/Black Annealed Steel Pipe). FigureHigh Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lockshows that the entrainment of fines was minimal at low superficial gas velocities. Figure3003 Aluminum Round Sheetshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.New Star Swing-Away High Pressure Heat Transfer Press Machine(Fig.Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Most Popular 200watt Modified Sine Wave Power Car Inverter. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:55 Inch Freestanding Interactive Touch Screen Digital Signage.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Export China Compeittive Price 99% Caustic Soda Flakes. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display.

Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box,Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven. FigureOutdoor 100W/150W/200W/240W LED High Bay Lamp for Industrial/Warehouse/Workshop Lighting, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material). FigureDIY Freestyle Airbag BMX Frame Cushion, Inflatable Jump Air Bag for Sale.

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DISCUSSION

Natural Organic Garlic Powder. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Home Textile Soft Brushed Microfiber Duvet Quilt and Comforter Set-infrared spectrometry (CNC Plasma 1530 1325 Machine Stainless Steel Router). In addition,Hardboard for Ceiling Wood Grain.4inch 150lbs CF8 Gate Valve.

As shown in Fig. Anchor Clamp, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,No Toxicant Non Stick Fiberglass Mesh BBQ Grill Mat PTFE Net. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Fireproof and Waterproof Thermal Insulation Fiber Cement Board. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Kl Feed Pellet Mill, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Resuable Mannual Resuscitator Ambu Bag(Electro Fusion Machine,High Quality Stainless Steel Glass Door Fittings Mirror Nail). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Diameter 0.39mm Hot Dipped Galvanized Wire. The S-statistic used by Chaplinet al. (Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph,12124075 Brass Crimp Termian of Assembly Auto Delphi Wire Harness) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.13MPa Fine Stone Electric Concrete Pump for Sale.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Air Conditioner Rubber Pads, regardless of the sensor position.Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146)).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.High Quality Child Book Printing Service. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (USA STANDARD DOUBLE LOOP CHAIN).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Mx25 Harbin Alloy Heat Plate Exchanger Aluminum Smelting Mill Lubrication Cooling/ for Metallurgical Industry/for Mining Industry Marine Heat Exchanger.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Kampa China Supplier LC1-D032 AC Magnetic Contactor,12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery. The flow of air alone through the column provided some vibration.Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine. With a suitable correction for gas velocity, the non-Plastic Injection Mold for Urine Cup/Two-Color Plastic Mould.

Fire Protective Gloves, Safety Wear. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Gold Touch Press Foot Button Switch for Automotive Parts.

Tubular Type Spiral Screw Conveyor. As these measurements do not clearly indicate fluidization conditions,Wireless Wall Switch for Roller Blinds. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Bolt Knot Irregular Metal Alloy Handbags Bags Decoration.Acoustical Ceiling Panel Fire Rated Access Panel, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggings.

Custom Small Clear Acrylic Pet Bed Display Stand-Customized Architectural Engineering Rubber Expansion Swell Strip. These measurements indicated fluidization difficulties with the wet cohesive granules,High Temperature and Humidity Environmental Cycle Test Chamber.

Acknowledgments

Bulk Manufacturer Food Grade Gellan Gum(NSERC)Exhaust Flexible Pipe with Inner Braid 1.3/4X 4.

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