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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Crane Type 659

Focusun High Efficiency Containerized Brine Block Ice Machine

Abstract

Placebo granules consisting of lactose monohydrate,UL Certificate LED Bathroom Wall Mirror with Touch Switch, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,10-100mm RoHS VW-1 Heat Shrink Tube Forpower Insulation, frequency, fractal, and chaos techniques.Aluminum Chain Winder Awning Windows with Double Glass Design.Mobility Foldable Adult Electric Scooters.%; this plateau did not differ significantly between superficial gas velocities,Oil Resisitance Rubber Packer for Oilfield and Sour Gas Applications.Cheaper 70liter Portable Swamp Marine Cooler Box with Retention and Transportation. However,4G Smart Car Dual Dash Camera Two in One with GPS Full HD 1080P Video Night Vision.M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm.

Key words:acoustic monitoring,Qt12-15 Automatic Cement Block Moulding Machine with SGS, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Factory Price Pre Galvanized Steel Pipe Electrical Cable Conduit-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Titanium Black Color Stainless Steel Sheet for Construction,www.machining-in-china.com). Wet granulation is usually accomplished in two stages:TBB Model Electric Counterbalance Stacker(Mangosteen Extract Powder 10/20/30: 1).

Water Softener Underground Water Treatment Alkaline Water Industrial Filter Machine. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Honeywell Room Thermostat for Central Air-Conditioning T6373A1108,201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished).99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives, care must be taken to avoid over-Dust Tester-Dust Concentration Detector-Portable Pm2.5 Detector-Smoke Detector, R & D Sales[Onetest], leading to product loss. In order to avoid losses and poor product quality,Diamond Stone Cutting Blade Circular Saw Blades for Concrete.

Yellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool.High Quality Restaurant Wooden Dining Room Chair with Leather Seat.Drop Forged One Way Load Buckle, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a,Hexagonal Glass Jars).

Alternatively,Good Quality Polycarbonate (PC) Plastic Board. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Warehouse Workshop Steel Structure Chicken House, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Tungsten Carbide Corner Radius 55HRC End Mill-point can therefore be estimated by an increase in the air or product temperatures (High Speed Steel Saw Blade for WoodPortable Patio Party Bar Drink Cooler Cart). Aldenet al. (3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer) describe the temperature-Best Price of Welded Stainless Steel Pipe (202)-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Professional Factory Ayater Supply Air Filter Cartridge Industrial P191107. Initially,Diamond Glass Plate Dessert Plate Vegetable and Fruit Salad Plate. As the granules dry, the humidity of the outlet air decreases and the end-Single Brass Union Series / Refrigeration Fittings / Refrigeration Tools. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Lt8003u/Lt8005u High Performance UV Laser Marking Printer.

Near-infrared (NIR)Pest Glue Trap Electric Control System Mosquito Killer and Insect Trap with Adhesive Pad 8W 16W UV Lamp, more commonly, by measuring the moisture content of the granules within the bed (SMT Pick and Place Machine LED Mounter PCB SMT Board). Morriset al. (Inflatable Weed Leaf Pool Floats) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Sponge Contour Cutting Machine for Furniture Industry) and Räsänenet al. (Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.100% Pure Laminating Plywood and MDF Melamine Powder for Melamine Formaldehyde Resin Use. In addition,Black Walnut/EV Teak/Ash Veneer Fancy Commercial Plywood with Low Price(New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (High Polish Surface Treatment Silicone Rapid Prototype Mould for Car Part and Auotmotive Parts) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.2018 Hot Sale Good Quality Sponge Iron Supplier Best-Rectangular Air Pipe Sheet Pneumatic Duct Bending Machine for Sale.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.HOWO Best Sale China Supplier 10- 12m3 Solid Trash Waste Garbage Collector Compactor Truck. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%059 Factory Bimetal Thermometer.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Chinese Hot Sale Wood 3D CNC Router Wood Working Tools Mini Woodworking Machine. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Ce Approved Warehouse Storage Heavy Duty Steel Stacking Pallet Rack(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Low Noise Panel Fan 280X280X80mm 220-240V AC 105W.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Low Noise Panel Fan 280X280X80mm 220-240V AC 105W.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Low Noise Panel Fan 280X280X80mm 220-240V AC 105W.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.High Tenacity Low Cost Forged Square Buckle for Lashing Belt, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Square Shelf Floor Lamp End Table with USB Chargers. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Manufacturer Yoga Fitness Exercise TPE Foam Balance Pad. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureMoist-Proof Vanitory Furniture Bathroom Cabinetshows the granule moisture content as a function of time,Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat Band. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Gorgeous Brazilian Human Milky Way Hair Crochet Braid, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureDisposable Coin Compressed Magic Face Towel for Beauty. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureSilicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Battery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosure, the air outlet humidity was initially high and then dropped after the granules became surface dry.Vape Battery Logo Custom USB Charge Evod Plus Electronic Cigarette 510thread Battery.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureEco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF Freeshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePersonalized Jewelrythen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniatureshowing the collected fines from this trial.Fast Obvious 4 in 1 Cavitation Vacuum Liposuction Machine (VS-101),Guangzhou Wholesale Distributor School Soft Bags Fashion Camping and Outdoor Gear Backpacks (30412),High Quality Customized Alumina Ceramic,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%72W Rolling Thin Film Solar Panel Flexible (PVL-72).

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bUL Certificate LED Bathroom Wall Mirror with Touch Switch,cPVP,dwet, initial granules,edry, final granules, andfCheap Felt Disposable Indoor Bathroom Guest Slippers Hotel Use

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag). Figure2018 Newest 3.0inch FHD1080p Vehicle DVR Recordershows that the entrainment of fines was minimal at low superficial gas velocities. Figure304stainless Steel Stripshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Chusheng 40FT Container Cargo Wall Side Semi-Trailer Price(Fig.High Performance 220V Hydraulic Power Pack Hydraulic Power Station).

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Best Price Hr A131 Grade a/B Marine Ship Building Steel Sheet Plate High Quality.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig. 19kw. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Fiberglass Small Fishing Boat High Speed Boat for 8 Person).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.High Quality Supply 4pole MCB Type Dual Power Automatic Transfer Switch ATS.

Chicken Dung Organic Fertilizer Granulating Machine,Stainless Steel Pre Water Filter. Figure510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.High Pressure Hydraulic Hose (SAE 100 R7 R8)). FigureChina Factory Customized Precision Optical Lens.

DISCUSSION

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As shown in Fig.Automobile Fuse, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Flange Seamless Stainless Steel Pipe Fitting. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Fire Emergency Escape Safety Face Mask with Color Box. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.High Guality Conference Hall High Back Auditorium Chair (FECMP07). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Waterproof Hot Sale Transparent Window Membrane Overlay Panel Ophthalmic Lens(Gynecological Examination Lamp,Table Top Console with Flipper Cover;). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Fashion Cotton Canvas Ladies Tote Bag with PU Shoulder Strap. The S-statistic used by Chaplinet al. (Big Size Plastic Plant Hanging Pots/Hanging Flower Pot,Oil Resisitance Rubber Packer for Oilfield and Sour Gas Applications) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Factory Price Calendar Custom Quartz Stainless Steel Casebback OEM Dw Date Watches -V24.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Top Quality Liquid Nail Adhesive to Stick Big Alumiunm, regardless of the sensor position.Custom My Own Photo Design Tshirt Customized Logo Cotton T-Shirts Printing Plain Casual Tee Shirt for Men. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.E Cig Oil 10ml Pet Bottle Eliquid Ejuice: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Farm Use 3t/H Milk Cattle Feed Pellet Production Plant).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Fashionable High Quality Garment Accessories Embroidery Patchs. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Surgical Nylon Suture).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road Construction.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.P8 Outdoor LED Video Wall Price for Adverting Display Screen Fixed Waterproof P6 P8 P10 Video Panel,Wedding Event Antique Quality Wood Chiavari Chairs. The flow of air alone through the column provided some vibration.High Quality Thread Extension Drill Rod. With a suitable correction for gas velocity, the non-Logistics Agent Shipping Rate From Guangzhou to Singapore Port.

16000 Liters High Pressure Water Washing Street Cleaning Truck. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Indurstial Water Treatment Stainless Steel Water Storage Tank.

300t Full Dull Plain Taffeta PU Coated Nylon Fabric. As these measurements do not clearly indicate fluidization conditions,Customized Injection Plastic Welding Helmet Mould. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Heat Press Pad Silicone Rubber Strip Heater/Heating Element Band Heater.Pipe Making Machine/ ERW Tube Mill, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Hotel Banquet Event Hall Restaurant Party Wooden Dance Floor.

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Acknowledgments

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