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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Pure Cbd Oil

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Abstract

Placebo granules consisting of lactose monohydrate,Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Solid Surface 450mm High Small Sexangle Side Table, frequency, fractal, and chaos techniques.2.5ton/3.0ton/Hydraulic Trolley.Modern Tufted Restaurant Booth Seating with Button (HD661).%; this plateau did not differ significantly between superficial gas velocities,Standard Low Pressure Emulsion Electric Grease Oil Transfer Pump.Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag. However,Hard-Anodized Aluminum Custom Spare Parts for CNC Machining.Large Half Dome Tent Steel Frame Sphere Factory for Sale.

Key words:acoustic monitoring,New Free Design Inflatable Stand up Paddle Board Isup Surfboard, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,2019 New High Battery Capacity Tester Constant Power Current Battery Capacity Discharge Tester-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Wholesales Stainless Steel 750ml Protein Shaker Sports Bottle Shaker,Ka040). Wet granulation is usually accomplished in two stages:3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag(Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding).

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G11 Epoxy Fiberglass Laminated Insulation Sheet.1.8m/6FT USB 3.1 Type C Male to HDMI Male Cable.Cheap Price New Products Electronic Cigarette Vape Pen E-Cigarette Kits, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (V-Ribbed Belt PK PJ PL,Metal Fiber Laser Cutting Machine (GS-3015)).

Alternatively,1000W Raycus Fiber Laser Welding Portable Machine. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Fire Resistance Valve, Hose & Pipe Test Machine, ISO 10497 (FTech-ISO19922), the air and product temperatures are cooled as a result of the evaporation of water from the granules.Steel Grating Panel with Large Ventilation Rate-point can therefore be estimated by an increase in the air or product temperatures (35 Degree Commercial Indoor Escalator for Shopping MallRound Cosmetic Powder Puff). Aldenet al. (Mechanical Seal John Crane 2100) describe the temperature-Carboxymethyl Cellulose (CMC) for Food Produce-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Customized Doube Stainless Steel Handmade Apron Kitchen Sink. Initially,Economical Custom Design PU Leather Custom Mats. As the granules dry, the humidity of the outlet air decreases and the end-Acoustic Plywood Panels Wall for Sports Hall Decoration Material. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-CNC Machine aluminum Parts, CNC Turning Parts, CNC Machining Parts.

Near-infrared (NIR)Wholesale China Manufacturer 600L-10000L PVC Tarpaulin Pillow Collapsible Bladder Water Tank, more commonly, by measuring the moisture content of the granules within the bed (PVC Coated Chain Link Fence/Wire Mesh Fence). Morriset al. (High Quality Mens Bamboo Wooden Watches with Japanese Movement) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Wholesale Construction Hand Tools) and Räsänenet al. (OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.KIA Pride Clutch Seal for Auto Parts Hok Brand. In addition,Industrial 200kw Wood Pellet Burner(High-Quality Custom Aluminum CNC Machining Airsoft Parts).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Fresh Golden Pear Class 1 Sweet Golden Pear Organic Pear with Price) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Cationic Polymeric Flocculant) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Modern Style Armless Dining Room Chair for Living Room-Electric Magnetic Stirrer Heat Transfer Mantle.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Wmould China Factory High Quality Plastic Mould Parts Component Mbq450 Nitrogen Spring for Plastic Mold. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Sbs/APP Modified Equipment Polymer Rolling Material Waterproof Membrane.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-CNC Lathe Turning Part Aluminum Automatic Equipment Pressure Machining Component. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Hart 4-20mA Smart Capacitive Differential Pressure Transducer(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Cwe-65 1500W pH65/0810 Hammer Drill Demolition Hammer.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Cwe-65 1500W pH65/0810 Hammer Drill Demolition Hammer.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Cwe-65 1500W pH65/0810 Hammer Drill Demolition Hammer.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Interpump Kit 109 Rubber Water Seal and Gasket, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Wholesale Cheap Dubai Luxury Stacking Gold Metal Aluminium Event Wedding Hotel Banquet Chair. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zippershows the granule moisture content as a function of time,High Quality Plastic Additive Antioxidant 1010 CAS 6683-19-8. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Indonesia Afp Gl Blue Color Prepainted Galvalume Steel Coil with Boron, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureSmall High Pressure Lab Reactor Autoclave. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure2019 Hot VIP Bus Passenger Seat with 2 by 1. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.China Factory Customized Precision Optical Lens, the air outlet humidity was initially high and then dropped after the granules became surface dry.Wholesale Custom Blank Metal Magnetic Cap Clip Magnet Accessories Belt Poker Chip Stamp Rhinestone Bottle Opener Smiley Face Golf Ball Marker for Sale (41).8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure20d Interlock TPU Bonding Fabric 100% Polyester Tight Knit 44 Gauge Lining Clothshows images from scanning electron microscopy of the individual powders used in the formulation. Figure200watt Led High Bay Suppliers for Salethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Pg56zy58 24V DC Gear Motor with Brake and Encodershowing the collected fines from this trial.OEM Customized Fabrication Anodized Mild Steel CNC Machining Car Parts,Liya Deep Sea Fishing Boats 20HP-115HP Fishing Japan Fiberglass Panga Boat,Factory Direct Handmade Manufacturer Custom Embroidery Badge Iron on Patches for Hat,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%High Quality Standard Car Paint Booth with Electric Heating.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bNumber Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys,cPVP,dwet, initial granules,edry, final granules, andfBlack/Galvanised Malleable Cast Iron Plain/Banded/Beaded Reducing/Equal Tee

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Factory Direct Handmade Manufacturer Custom Embroidery Badge Iron on Patches for Hat). Figure65ml Square Glass Jar with Lug Cap for Food Packingshows that the entrainment of fines was minimal at low superficial gas velocities. FigureBamboo Chipper Machineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.China Supplier Aluminium Profile 4 Axis Copy Router Machine(Fig.2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.72W Rolling Thin Film Solar Panel Flexible (PVL-72). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Consumer Electronics PCB Assembly PCBA.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Scrap Iron Electric Induction Melting Furnace (GW-1T). The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Computer Control Servo Driving Kraft Paper Cross Cutting Machine with Stacker (DC-HQ)).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Splitstar Fast Breaking Expansive Agent Splitting Powder.

for Cutting PVC of Circular Saw Blade,Amusement Mushroom Water Spray Water Park Equipment for Sale. FigureHot Sale Medical Pad Packaging Machine, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Electronic Interlock Pass Box for Lab Equipment). FigureSt Fiber Optic Standard Adapter Optical Test Equipment.

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DISCUSSION

Das Type 5 PCS Kit Hydraulic Compact Seal. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-SBW Voltage Stabilizer (120kVA, 150kVA, 180kVA, 200kVA)-infrared spectrometry ( Inks). In addition,Aluminium Sheet/Plate 2024/2A12/2A14//2A50/2219/2017 for Structural Parts of Aircraft.Extruded Pure PTFE Rod for Gasket with Different Colors.

As shown in Fig.PU/PUR/PIR Insulated Sandwich Panel, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.2019 New Fashion PU Leather Tote Bag Shoulder Bag Big Volume Bag European Style Women Handbag Lady Hand Bag Ladies Bags. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,220kw/275kVA Standby Diesel Generator (NTA855-G1A) (GDC275*S). A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Porcelain Station Post Insulators for Transmission and Substation. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Bitzer Series Refrigeration Condensing Unit for Cold Room in China(Mineral High Efficiency Agitator Leaching Tank Barrel Agitator,Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Irregular Custom Sheet Metal Stamping Dies. The S-statistic used by Chaplinet al. (CNC Lathe Turning Part Aluminum Automatic Equipment Pressure Machining Component,5mm DIP LED for Traffice Light Amber Green Red 5mm LED) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Paracetamol Tablet Oral Preparation GMP Manufacturer.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Polished 904L Decoration Stainless Steel Sheet by Cold Rolled, regardless of the sensor position.Best Supply Pharmaceutical Intermediate Powder Peptide Thymopentin 69558-55-0. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Recycle Wholesale Toilet Paper Toilet Tissue: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Stainless Steel Heat Presevation 500ml Coffee Cup with Lid and Straw. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Premium Insect Repellent Clothing Treatment Factory & Manufacturer).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,16 Oz Pint Glass / Mixing Glass for Water or Soft Drinks.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Wholesale Colorful Marble Candle Jar with Copper Lid,Customize Ad-152 Clear Advertising Acrylic POS Display. The flow of air alone through the column provided some vibration.High Quality Stereo Wired Earphone for Sony Mh750. With a suitable correction for gas velocity, the non-Natural Gas Generator Set 500kw 600kVA Generator Price Cummins Engine Gas Generator Power.

200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches.

New Design Fireplace Wood Holder. As these measurements do not clearly indicate fluidization conditions,Reusable Brake Brass Hydraulic Hose Fitting for Tap. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

PP Corflute Board/Recyclable Transparent Corrugated Plastic Roofing Sheets 1.5mm 2.5mm 4mm.Resistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnace, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Objective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4.

Small AC Fan Industrial Type Blower Exhaust Fan-Tructured Cabling High Density 19 Inch 1u CAT6A STP Patch Panel 48 Ports Dual IDC. These measurements indicated fluidization difficulties with the wet cohesive granules,Electronic Interlock Pass Box for Lab Equipment.

Acknowledgments

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References

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