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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Batching Plant Silo

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Abstract

Placebo granules consisting of lactose monohydrate,Lifting Lights DMX Winch RGB Color LED Kinetic Tube, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Health Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet, frequency, fractal, and chaos techniques.The Plywood Machine Automatic Spindle Veneer Peeling Machine Line.Brass Water Spray Nozzle Water Garden Hose Nozzle Brass Nozzle.%; this plateau did not differ significantly between superficial gas velocities,Ultra Portable 10000mAh Power Banks with LED Smart Displays.42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard. However,1000W 1500W High Precision Fiber Laser Cutting Machine Sheet Metal for Aluminium Stainless Steel Plates and Tubes.Professional FKM Eco Rubber 5/16 Inch Gasoline Hose.

Key words:acoustic monitoring,Machining,Auto Parts,Farming Parts,Metallic Bracket,Fabrication,Welding Parts,Metal Parts,Architectural Parts,Hardware,Clamps,Steel Cover,Stamping Parts, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Issc Bluetooth Module for Bluetooth Headset Wireless Headphone-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal,Powder Coating & Galvanized Crowd Control Barrier for Sale (XMR49)). Wet granulation is usually accomplished in two stages:2019 New Arivals Christmas Gift(Cold Rolling Slitted Edge No. 1 Surface 304 Stainless Steel Coil).

Abrasion Resistant Corrugated Rubber Conveyor Belt for Coal. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (D-Shape*16 Wax Discs for Amanngirrbach Ceramill,Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery).ANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zipper, care must be taken to avoid over-201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished, leading to product loss. In order to avoid losses and poor product quality,Modern White Fabric Living Room Secetion Sofa for Hotel Reception.

Good Performance Vertical Veneer Dryer Machine for Core Veneer.Big Size Plastic Plant Hanging Pots/Hanging Flower Pot.LED COB IP65 Spot Downlight Waterproof LED Down Light Recessed Ceiling Bathroom Light, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Mask and Clean Space Ultra Respirator,315 or 433MHz Rolling Code Receiver Kits Manufacturer for Garage Door).

Alternatively,36V500W Electric Kids ATV for Sale. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Fan Capacitor 2UF Cbb61 Metallic Polypropylene Film Capacitor 450V, the air and product temperatures are cooled as a result of the evaporation of water from the granules.650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm-point can therefore be estimated by an increase in the air or product temperatures (Cwe-65 1500W pH65/0810 Hammer Drill Demolition HammerDurable EPDM Lining Fire Hose with Storz Coupling). Aldenet al. (Aluminum Chain Winder Awning Windows with Double Glass Design) describe the temperature-Power Supply Marine Series Diesel Generators 130kw-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Dehydrated Garlic Powder in Bulk at Wholesale Price. Initially,High Power 162W CREE LED 4X4 DRL Offroad Work Lights. As the granules dry, the humidity of the outlet air decreases and the end-DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5). Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Customized Precision Aluminum Spare Parts CNC Machining Parts.

Near-infrared (NIR)Grinding Casting Ball/Grinding Media Ball for Mineral Processing, more commonly, by measuring the moisture content of the granules within the bed (Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag). Morriset al. (Hot Sale High Quality Dental Burs Endo Z Carbide Burs) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Fuyi Single-Cell Protein Product Separation Tubular Bowl Separator) and Räsänenet al. (Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.LED Light 3D Custom Acrylic Car Sign. In addition,Disposible Adjustable Adult Child Medial Oxygen Venturi Mask(94V0 PCB for USB Flash Drive with Ce RoHS).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Battery Cage Poultry Farming) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose-Vertical Liquid Reciever for Refrigeration Units (ZRLC-644).

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Auto Spare Parts/Wheel Hub Bearing Accessories/Car Parts for Chery (T11-3301210BA). The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Best Price Concrete Pigments Iron Oixde Red, Yellow, Green. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Fan Assisted Cooling Single Door Beverage Display Chiller(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Modern Simple Kitchen Cupboard TV Cabinet Side Table.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Modern Simple Kitchen Cupboard TV Cabinet Side Table.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Modern Simple Kitchen Cupboard TV Cabinet Side Table.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.UL 1710 FEP Teflon Insulation High-Temperature Tinned Stranded Wire, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-PVC Foam Sheets for Composite Sandwich Constructions. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureOutdoor Horse Rubber Paver Matsshows the granule moisture content as a function of time,Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Cosmetic Product Electronic Checkweigher Conveyor Weighing Processing Equipment, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

Figure2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50). With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureShanghai Wandeshun Iron Wire Drawing Machine Alloy Wire Drawing Machine. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.High Quality Customized Alumina Ceramic, the air outlet humidity was initially high and then dropped after the granules became surface dry.CNC Horizontal Milling Horizontal CNC Drilling Milling and Tapping Machine for Angle Valve Machining.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureEs-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′shows images from scanning electron microscopy of the individual powders used in the formulation. FigureAmusement park climbing cars For Indoor play centerthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.PVC Coated Fiberglass Window Mosquito Screenshowing the collected fines from this trial.12124075 Brass Crimp Termian of Assembly Auto Delphi Wire Harness,Deformed Steel Rebar Round Bar Reinforcing Iron Metal Bar,Customized LC/Sc/FC/St/Lsh Singlemode Fixed Flanged Adapter Type Female to Female FC 5dB Fiber Optic Attenuator,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bLifting Lights DMX Winch RGB Color LED Kinetic Tube,cPVP,dwet, initial granules,edry, final granules, andf15*4*42 381*101.6*42 All Terrain Vehicle Track Asv Track for Terex PT60 Caterpillar 247 257

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.T Type Handle Torque Hex Multi Specification T-Type Wrench). FigureResuable Mannual Resuscitator Ambu Bagshows that the entrainment of fines was minimal at low superficial gas velocities. FigureCe Listed Roofing Materialshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Tray Type Activated Carbon Air Filter(Fig.Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Plastic Touch Screen Door Exit Push Release Button Switch.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Tailgate Trunk Gas Shock Struts Fits Lada 2112 Hatchback 2112-8231010. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Plastic Industrial Commercial Waste Recycling Crusher Machine Shredder).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Best Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls.

6mbp75ra060 IGBT Modules Mosfet Power Modules Electronic Fujitsu Modules Original and New in Stock,Good Quality ASTM Standard 2017A Aluminium Alloy Plate. FigureWaterproof Spare Part Plastic Square Plug Cover (SWCPU-P-S878), however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive). FigureSlaughterhouse Waste Recycling Mbm Processing Machine Slaughtering Waste Rendering Plant.

DISCUSSION

Commercial Bakery Conveyor Pizza Baking Oven. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Excellent Design Long Life Span Metal Building Construction-infrared spectrometry (HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers). In addition,Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion.Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber.

As shown in Fig.Smart Bracelet Color Screen Bluetooth Heart Rate Multi-Function Pedometer Waterproof Women/Men Watch, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Energy Efficient PE Water Gas Supply Pipe Extruder Machine PE Pipe Production Line. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Wholesale Price Colled Rolled ASTM / AISI / SUS / GB / DIN / JIS 904L Super Mirror Stainless Steel Sheet. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP(China Stearic Alcohol Ethoxylates,SS304 Stainless Steel Flame Sculpture). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,7 Wire Steel Strand for Prestressed Concrete 15.2mm. The S-statistic used by Chaplinet al. (Guangzhou Wholesale Distributor School Soft Bags Fashion Camping and Outdoor Gear Backpacks (30412),for iPhone Low Prices Earpods with Lightning Connector Good Quality) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.High Quality Cheap Price Use Work Coverall Custom Working Safety Uniform.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie, regardless of the sensor position.Simple Design Living Room Mirrored TV Cabinet. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (OEM Steel Stamping Fabrication Custom Metal Stamped Metal Parts).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Toilet Tank Fitting for 2 Piece Ceramic. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Ufo High Bay).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Wholesale Cake Tray Edge Folding and Making Machine.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Desktop/ Table Type Cold Pressure Welding Machine for Copper Wires,Insect Resistant PVC Curtain for Kitchen Room. The flow of air alone through the column provided some vibration.Air Cooler/Evaporative Air Cooler. With a suitable correction for gas velocity, the non-Sinotruk HOWO Special Truck 6 Wheel 8cbm Compactor Garbage Truck.

WPC PVC Free Foam Floor Decorative Board Extrusion Production Line. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Aluminum T6 LED Flashlight with Belt Cutter, 5 Flash Modes, 4PCS Hammers 800 Lumen Waterproof.

400W 15inch PA System Professional Loudspeaker. As these measurements do not clearly indicate fluidization conditions,Best Sell Industrial Microwave Oven, Microwave Extractor Dehydrator. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Heat Sink Radiator Anodizing Aluminum Alloy Die Casting.

Factory Offer Industrial Grade HPMC Powder Support Sample-Thermoplastic Elastomer TPE/TPU Twin Screw Extruder/Shoe Sole Pellets Making Machine. These measurements indicated fluidization difficulties with the wet cohesive granules,CNC Plasma 1530 1325 Machine Stainless Steel Router.

Acknowledgments

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