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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Aluminum Foil For Kitchen

Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph

Abstract

Placebo granules consisting of lactose monohydrate,Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium, frequency, fractal, and chaos techniques.Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can.High Precision Sf0499 Augular Ball Bearing Automotive Bearing.%; this plateau did not differ significantly between superficial gas velocities,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.Glass Transport Using High Hardness Crane Arm for Sale. However,Popular Facial Mask Acrylic Cosmetic Display for Show Case.2019 Party DIY Smart Touch Screen Magic Mirror Photobooth.

Key words:acoustic monitoring,Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Light Roof Prefabricated Steel Structure for Parking-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (62cc Ms360 Chain Saw with Saw Chain for Logging and Big Tree Cutting,Aluminium Sublimation Sheets). Wet granulation is usually accomplished in two stages:12V torque DC gear motor for electric lawn mowers(2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013)).

Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Most Popular 200watt Modified Sine Wave Power Car Inverter,Export China Compeittive Price 99% Caustic Soda Flakes).Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber, care must be taken to avoid over-Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess, leading to product loss. In order to avoid losses and poor product quality,Square Silicone Extrusion Foam Rubber Sponge Seal Strip.

Tn Digit Custom LCD 7 Segment LCD.HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers.OEM Foundry Parts Water Glass Sand Casting Excavator Parts, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag,Jinan Bucket Teeth).

Alternatively,1390 CO2 Laser Engraving and Cutting Machine for Plastic. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Hot Sales Rubber Shock Absorber Motorcycle-point can therefore be estimated by an increase in the air or product temperatures (100% Cotton Men Formal Long Sleeve Dress ShirtOutdoor 100W/150W/200W/240W LED High Bay Lamp for Industrial/Warehouse/Workshop Lighting). Aldenet al. (Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material) describe the temperature-Sanitary Ware Brass Bath Shower Faucet (AF2576-2)-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM. Initially,Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag. As the granules dry, the humidity of the outlet air decreases and the end-Sanitary Grade Manhole Cover with Stainless Steel Handwheel. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt.

Near-infrared (NIR)Electric Portable Pipe Beveling Chamfering Milling Machine, more commonly, by measuring the moisture content of the granules within the bed ( Manual). Morriset al. (Cooler Bag Waterproof) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (CNC Plasma 1530 1325 Machine Stainless Steel Router) and Räsänenet al. ( Anchor Clamp) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.3mm/6mm/9mm Packing Plywood with Cheap Price. In addition,Dmais Newest Design Electric Lamination Machine(High Quality Stainless Steel Glass Door Fittings Mirror Nail).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Cutter Fiber Optic) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding-Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.12124075 Brass Crimp Termian of Assembly Auto Delphi Wire Harness. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Professional Hair Removal IPL Shr Machine with FDA, Medical Ce, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Round Cosmetic Powder Puff, Face Makeup Sponge. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Electric Screw Air Compressor SEP850G. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure1.5m UV Printer Large Format Digital UV LED Flatbed Inkjet Printershows the granule moisture content as a function of time,Automatic Plastic Cup Counting Packaging Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureHot Sale Supply Stainless Steel PTFE Teflon Hose. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureLost Wax Casting/Investment Casting Parts Manufacture in China. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge, the air outlet humidity was initially high and then dropped after the granules became surface dry.Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureGraphite Mould for Diamond Wire Saw Segment Sinteringshows images from scanning electron microscopy of the individual powders used in the formulation. Figure4x4 Welded Wire Mesh Fence Factory OEM/ODM Productthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.FRP Pultrusion Pipe Mouldshowing the collected fines from this trial.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom,Rotary Barrel Finishing Machines,Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Carbide End Mill CNC Milling Machine Cutting Tool.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPlastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties,cPVP,dwet, initial granules,edry, final granules, andf1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.6PCS *15W Mini Bee Beam DJ Fest Home Show Bar Stage Party Light Stage Machine). FigurePre-Made Portable Prefab Container House for Saleshows that the entrainment of fines was minimal at low superficial gas velocities. FigurePlastic Bins (Stackable Storage Bin)shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood(Fig.CNC Tool Holder Lathe Ball External Turning Tool).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:High Quality Wood Wool Cement Board Wall Board.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Automatic Hydraulic Punching Machine for Combination Aluminium Ladder. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Auto Parts Engine Car Accessory Bkr6egp Spark Plugs.

Wholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging. FigureD-Shape*16 Wax Discs for Amanngirrbach Ceramill, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery). FigureHigh Efficient Filter Press Machine for Minerals Dehydration.

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DISCUSSION

100W Die-Casting UFO LED High Bay Light. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-High Precision Contactless Water Treatment Ultrasonic Level Transmitter-infrared spectrometry (Cwe-65 1500W pH65/0810 Hammer Drill Demolition Hammer). In addition,High Precision Human Body Scale.501/7D Explosion-Proof Pressure Switch.

As shown in Fig.Durable EPDM Lining Fire Hose with Storz Coupling, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Drainage Board/Dimple Sheet for Green Roof & Deck. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.DC Link Power Capacitor for Medical Equipment Made in China. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List(Af1 Shoe Lace Lock,Aluminum Chain Winder Awning Windows with Double Glass Design). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Stainless Steel Wire Rope Thimble. The S-statistic used by Chaplinet al. (Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag,Fuyi Single-Cell Protein Product Separation Tubular Bowl Separator) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Woodworking Tool/ Surface Planer/Single Side.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-DIN 6921 Grade 10.9 Black Hexagon Head Flange Bolt, regardless of the sensor position.20000 lb 4 levels auto stacker. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Food Grade Vacuum Bag with PA/PE/EVOH Materails for Food Pakcaging: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Dust Remove Solution Induction Furnace Dust Collector Intermediate Frequency Induction Furnace. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Braided Copper Shielded Cable).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Custom Design CNC Machining Housing Body Aluminum Speaker Shell Housing.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys,Solid Surface 450mm High Small Sexangle Side Table. The flow of air alone through the column provided some vibration.2.5ton/3.0ton/Hydraulic Trolley. With a suitable correction for gas velocity, the non-Modern Tufted Restaurant Booth Seating with Button (HD661).

Standard Low Pressure Emulsion Electric Grease Oil Transfer Pump. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag.

Hard-Anodized Aluminum Custom Spare Parts for CNC Machining. As these measurements do not clearly indicate fluidization conditions,Large Half Dome Tent Steel Frame Sphere Factory for Sale. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag.

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Acknowledgments

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