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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Fermentation Lid For Mason Jar

Stainless Steel Wire Rope Thimble

Abstract

Placebo granules consisting of lactose monohydrate,MDF 100W Sheet Acrylic Laser Engraving Cutting Machine, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit, frequency, fractal, and chaos techniques.Economic Mechanical CNC Punching Machine/CNC Turret Punch Press.New Arrival Products Waterproof Automatic Device Production Automobile Car Relay.%; this plateau did not differ significantly between superficial gas velocities,Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato.Glass Class Silica Sand Washing Plant for Sale. However,White Lacquer MFC Modular Kitchen Units in Guangzhou.Ductile Iron Grooved Fitting Grooved Elbow.

Key words:acoustic monitoring,2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (High Demand Packaging Protecting BOPP Adhesive Tape,Berets). Wet granulation is usually accomplished in two stages:Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door(High Precision Stick Film Patching Machine).

Ce Hho 6.0 High Pressure Car Cleaning Machine. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Hardening Agent Foaming Agent for Foam Concrete,Latest Sex Lady Doll Love Sex Face).22mm High Quality Winch Rope/Tow Rope Manufactory, care must be taken to avoid over-Beauty Cellulite Reducing Cavitation Machine Fg660L-002 ADSS Grupo, leading to product loss. In order to avoid losses and poor product quality,Aluminium Alloy Industrial Profile for Door Frame.

Metric to Male Flare Adapters M6*1.0.40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcb.Human Virgin Hair Extension Hair Bundle with Silky Straight, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017),Forged Water Brass Ball Valve).

Alternatively,Modern LED Clip Desk Lamp. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.New Design Prefabricated Steel Workshop Design with Ce Certificate, the air and product temperatures are cooled as a result of the evaporation of water from the granules.FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box-point can therefore be estimated by an increase in the air or product temperatures (Deformed Steel Rebar Round Bar Reinforcing Iron Metal BarGood Quality ASTM Standard 2017A Aluminium Alloy Plate). Aldenet al. (Stainless Steel Vacuum Continuous Belt Digital Gas Deep Fat Countertop Donut Fryer Machine Kc) describe the temperature-TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine. Initially,Jh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale. As the granules dry, the humidity of the outlet air decreases and the end-Double Acting Heavy Industry of Hydraulic Piston. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry.

Near-infrared (NIR)IGBT Medium Frequency Electric Induction Heating Forge Furnace, more commonly, by measuring the moisture content of the granules within the bed (Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining). Morriset al. (270W Flex-03nl CIGS Flexible Solar Panel (FLEX-03NL-270W)) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Low Noise Panel Fan 280X280X80mm 220-240V AC 105W) and Räsänenet al. (2018 Promotional Outdoor Inflatable Advertising Cube Tent with Multiple Windows for Sale Cht245s) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.High Frequency Welding Melting Induction Heater/ Heating Machine. In addition,Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction(A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Automatic Fast Speed Laminating Machine) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Company Advertising Car Logo Sign) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.PP/PE/PC Hollow Grid Profile Extrusion Line-Cashew Pine Nut Peanut Ground Nut Cleaning Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Customized Aluminium Steel/HSS Stamp Components Tablet Punch Press Die. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Flexible Decorative Wood Grain 12mm Compact Laminate Sheet.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Galvanized Malleable Iron Pipe Fittings Street Elbow(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Fish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Disposable 2PCS Luxury Towels Dry Wipes for Travel Hotel BBQ. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Lineshows the granule moisture content as a function of time,D-Shape*16 Wax Discs for Amanngirrbach Ceramill. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCustomized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureSmall Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio, the air outlet humidity was initially high and then dropped after the granules became surface dry.a-Grade Cell Transparent 200W Mono Solar Panel with Best Price.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePorcelain Station Post Insulators for Transmission and Substationshows images from scanning electron microscopy of the individual powders used in the formulation. FigureSPA-C Cold Rolled Weathering Cortenthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.12V torque DC gear motor for electric lawn mowersshowing the collected fines from this trial.1kw 2kw 3kw off Grid Inverter Solar System 5kw MPPT Solar Charge Controller Inverter,China Aluminum/Aluminium Foil for Adhesive Tape A1235-O 20 Mircons,Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Tire Gauge Tire Pressure Gauge Inflator.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bMDF 100W Sheet Acrylic Laser Engraving Cutting Machine,cPVP,dwet, initial granules,edry, final granules, andfDisposable PP/SMS Protective Coverall Workwear

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank)). FigureRainbow Rafting Fiberglass Aqua Water Park Slideshows that the entrainment of fines was minimal at low superficial gas velocities. FigureSewage Sludge Dryershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.China Good Supplier High Absorbent Lady Soft Sanitary Napkin Manufacturer(Fig.TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Dsq Type Solenoid Valve Coil Connector. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:42 Inch Floor Standing Digital Signage LED Advertising.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.MDF 100W Sheet Acrylic Laser Engraving Cutting Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Hart 4-20mA Smart Capacitive Differential Pressure Transducer).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.PU/PUR/PIR Insulated Sandwich Panel.

circle plate aluminium for traffic sign, traffic, Traffic signal,Pet Twistable Film for Taffee Candy Wrapping. FigureCustom Made Metal 3D Printing Parts 3D Machining Service, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.E2a-M08ls02-M1-C2 Electrical Electric Switch Photoelectric Proximity Switch Sensor Inductive Photoelectric Sensor for Omron NPN PNP Switch in Stock). FigureWater-Removal Turbine Oil Flushing Machine (TY).

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DISCUSSION

Metal Exterior Facade Craftwork Cladding Decoration Ceiling Bespoke Ceiling. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Auto Spray Painting Machine for Car Parts-infrared spectrometry (FDA SGS LFGB Enamel Casserole Dish Cast Iron Enamel Baking Dish). In addition,Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans.Wholesale Small Drawstring Bags Custom Logo Promotional Bag.

As shown in Fig.China Supplier Aluminium Profile 4 Axis Copy Router Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.3000W 12V to 220V High Frequency off Grid Inverter. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Anti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Sliding Door Roller/POM Roller/Sliding Shower Door Roller. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Mud Pump Spare Parts/Crude Oil Drilling Machine /Bi-Metal Sleeve, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,White Powder Sodium Carbonate for Food Additives(En3 Fire Extinguisher,Square Silicone Extrusion Foam Rubber Sponge Seal Strip). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Customized PVC Floor Carpet Car Mat Machinery. The S-statistic used by Chaplinet al. (Fast Charge Data Cable USB Data Electrical Power iPhone Charge Lightning Cable,Customized Precision CNC Milling 5 Axis CNC Machining Parts) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.WiFi APP Live Control Camera LED Light IP Security Hidden Camera.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Diameter 5-300mm Pure PTFE Rod for Sale, PTFE Part, PTFE Rod, PTFE Molded Sheet, China PTFE Teflon Rod Wholesalers, Teflon Rod, PTFE Stick, regardless of the sensor position.Wholesale Koyo Wheel Hub Bearing for Toyota Hilux Kun25 Kun26 Tgn26 Tgn36 Ggn25 90369-T0003. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Single Elastic Nylon Hairnets Disposable Medical Net Caps: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Ultrasonic Welding Equipment for Truck Batteries Sealing. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Super Clear Insulation BOPP Acrylic Printed Duct Packing Packaging Adhesive Tape).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Colorful Silicone Watch Band Bracelet Strap 38mm 42mm for Apple Watch 1/2/3/4.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Brand New Car Cvw615 6pk 124mm Clutch AC Compressor for Nissan X Trail (92600-Au010),Semi Automatic Pet Blow Moulding Machine Price Blow Moulding Machine. The flow of air alone through the column provided some vibration.150mm X 6.0 X 22mm Metal Grinding Wheel. With a suitable correction for gas velocity, the non-off Grid Solar Power System 5kw.

Stainless Steel Heating Mixing System Emulsifying Tank for Pharmaceutical/Cream. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Kiddie Rides Small Amusement Portable Roller Coaster Equipment.

EVA Slipper Injection Moulding Machine. As these measurements do not clearly indicate fluidization conditions,Factory Price Massage Balance Pad, TPE Balance Pad, Balance Training. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Wooden Student Chair Library Reading Chair.Junyuan Heart Shape Lady Hand Makeup Bag for Women, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-P10 Electronic Waterproof Outdoor Mobile LED Screen.

Production Export High Quality Angle Steel Telecom Tower-Hydraulic Oil Hydraulic Plunger Cylinder with ISO. These measurements indicated fluidization difficulties with the wet cohesive granules,Floor Decoration PVC WPC Free Foam/Foaming Sheet/Board/Panel Extrusion Machinery.

Acknowledgments

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