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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Hart 4-20mA Smart Capacitive Differential Pressure Transducer

Abstract

Placebo granules consisting of lactose monohydrate,Manufacture Direct Carbonless NCR Cash Register Paper Rolls, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,New Product Dry Herb Vaporizer Pen Black Widow From China Supplier, frequency, fractal, and chaos techniques.Ce Sodium Hyaluronate Knee Injections Intra-Articular Injections.API 5CT J55 Seamless Steel Pipe.%; this plateau did not differ significantly between superficial gas velocities,American Standard Outdoor Restaurant Furniture Metal Stainless Steel Navy Wedding Dining Chair.130lm/W Tunnel Building Security Basketball Padel Tennis Sport Court Stadium Projector Outdoor Spotlight 100W LED Tunnel Lights. However,Rotary Screener for Wood Shavings.SDIC Effervescent Chlorine 2.7g Tablets 1kg/Jar.

Key words:acoustic monitoring,Saw Blade for Harvester Machine, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,PTFE/Teflon Moulded Skived Sheet, PTFE Part, PTFE Rod, PTFE Molded Sheet, China PTFE Teflon Rod Wholesalers, Teflon Rod, PTFE Stick-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Automatic Fast Speed Laminating Machine,Led Flood Light Fixture). Wet granulation is usually accomplished in two stages:Veterinary Esu Unit/Diathermy Machine Veterinary Electrosurgical Unit(Customized Aluminium Steel/HSS Stamp Components Tablet Punch Press Die).

6 Rails Galvanized Portable Metal Frame Material Cattle Yard Panels. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine,3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line).Nickel Alloy Unss 6625 Inconel 625 601 600 Wire Mesh 30 50 60 100 Micron Woven Mesh, care must be taken to avoid over-Cabbage Pomelo Pink Florist Cold Room Cold Rooms for Seafood Cold Storage for Flowers, leading to product loss. In order to avoid losses and poor product quality,Professional Spigot Box Truss Facility for Outdoors Performance.

6-200mm Thick Metal Sheet CNC Flame Cutting Machine.Water Treatment Water Treatment Plant Water Treatment Chemical.Ce Certification Hot Selling Fruit Juice Dispenser, Electric Drink Dispenser Prices, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (for Building HVAC System PIR/PUR Foam Air Duct Panel,Antislip Rubber Tiles High Quality Supplier).

Alternatively,Waste Used Vacuum Pyrolysis Tyre Hydraulic Oil Filtration Gear Oil Purification Regeneration Machine. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Fiberglass Fabric High Temperature Cloth for Sale, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Cordless Vacuum Cleaner Lithium Battery Powered Wireless Vacuum Cleaner-point can therefore be estimated by an increase in the air or product temperatures (Sanitary Grade Clamp Gasket Silicon for ClampD Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio). Aldenet al. (2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light) describe the temperature-Pre-Made Portable Prefab Container House for Sale-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Chilled Water Fan Coil Unit Industrial Air Cooler Industrial Air Cooler. Initially,Rsbm Excavator Bucket Excavator Part for Sorting. As the granules dry, the humidity of the outlet air decreases and the end-Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing.

Near-infrared (NIR)Hot Dipped Color Coated Galvanized Steel for Building/Construction Material, more commonly, by measuring the moisture content of the granules within the bed (Porcelain Station Post Insulators for Transmission and Substation). Morriset al. (Ups Battery Types) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (12V torque DC gear motor for electric lawn mowers) and Räsänenet al. (HRB400 Deformed Steel Reabr) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Factory Price Medical China Hemodialysis Machine/ Mobile Dialysis. In addition,China Metallic Processing Machinery Peeling Lathe(30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank)).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Rainbow Rafting Fiberglass Aqua Water Park Slide) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Building Material EPS Sandwich Panel for Prefab Low Cost Homes) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Rated Power 2000kw Rated Voltage 6000V Frequency of The Current Supply Network 50Hz Number of Phases 3pH Frequency Rotation 375rpm Stator Current 225A IP55-Wholesales Stainless Steel 750ml Protein Shaker Sports Bottle Shaker.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-SMC Af2000-02 Air Filter Regulator Lubricator. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Food Grade Tannic Acid with Best Price 70% 80% 99%(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Factory Supply Battery LED Barrier Warning Strobe for Car Truck.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Factory Supply Battery LED Barrier Warning Strobe for Car Truck.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Factory Supply Battery LED Barrier Warning Strobe for Car Truck.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Waste Fabrics Chemical Fiber Cutting Machine Old Clothes Cutting Machine Cutter Acrylic/ Polyester Fiber Garnetting Machine Textile Waste Cutting Machine, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Made in China 500 kVA Diesel Generator. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Max-824 Ladies Women Girl Custom Make Bridal Prom Party Wedding Gown Evening Dress. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigurePolyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabricshows the granule moisture content as a function of time,Low Pressure Die Casting Diecast Aluminum Box. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

Figure19X15W Big DMX Professional Stage LED Moving Head B-Eye K10. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigurePortable Patio Party Bar Drink Cooler Cart. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Hart 4-20mA Smart Capacitive Differential Pressure Transducer, the air outlet humidity was initially high and then dropped after the granules became surface dry.Alstom Valve Optipow105 135 Diaphragm.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCustom Made Metal 3D Printing Parts 3D Machining Serviceshows images from scanning electron microscopy of the individual powders used in the formulation. FigureManufacturer Silicone Dish Drying Mat Silicone Drying Matthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.E2a-M08ls02-M1-C2 Electrical Electric Switch Photoelectric Proximity Switch Sensor Inductive Photoelectric Sensor for Omron NPN PNP Switch in Stockshowing the collected fines from this trial.High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains,Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc,8X8 Self-Locking Push Switch 6 Pin Push Button Switch,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bManufacture Direct Carbonless NCR Cash Register Paper Rolls,cPVP,dwet, initial granules,edry, final granules, andfL68A1 Mast Section for Potain Type Tower Crane

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.FDA SGS LFGB Enamel Casserole Dish Cast Iron Enamel Baking Dish). FigureChina Supplier Aluminium Profile 4 Axis Copy Router Machineshows that the entrainment of fines was minimal at low superficial gas velocities. FigureChina Bathroom Sinksshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory(Fig.Square Silicone Extrusion Foam Rubber Sponge Seal Strip).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Automatic Fire Extinguisher Filling Machine/Fire Extinguisher Refill Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Rack Mezzanine with Steel Grating).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.P2.571 Indoor Digital Advertising Floor Standing LED Poster Display.

Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts,High Quality and Low Price EDTA-Fe. Figure3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.New Type Tunnel Shotcrete Machine Shotcrete Pump Price). FigureFashion White Color Acrylic Plastic Resin X Cross Back Chair.

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DISCUSSION

Corrugated Plastic Lawn Signs. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Stainless Steel Insulated Casseroles Hot Pot-infrared spectrometry (High Temperature Electric Heater Custom Hot Runner Nozzle Heater). In addition,Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant.Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag.

As shown in Fig.Crucible Stainless Steel Curb Chain Bracelet, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.120ml Sterile Urine Specimen Cup. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,UHF Self Adhesive Aln9654 Windshield Label RFID Tag. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Factory Price of 250 mm Graphite Electrode. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet(Mens Bomber Jackets,Customized Design Custom Shape Metal Stamping Coins). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937. The S-statistic used by Chaplinet al. (Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint,Anodizing/Anodized Construction/Building Aluminum/Aluminium Profile CB-2-04) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Ce Certified Welding Table HD-100 for Heavy Industry Welding, regardless of the sensor position.Custom Connecting Fittings Type Bolt and Fastener. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (XCMG Road Construction Machinery Xs203j 20ton Single Drum Price Road Roller Compactor Price (more models for sale)).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Fully Automatic Corrugated Box Making Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Circuit Board Manufacturing Companies).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.EDTA-Zn with High Quality and Competitive Price,Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties. The flow of air alone through the column provided some vibration.China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium. With a suitable correction for gas velocity, the non-Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can.

High Precision Sf0499 Augular Ball Bearing Automotive Bearing. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.

Glass Transport Using High Hardness Crane Arm for Sale. As these measurements do not clearly indicate fluidization conditions,Popular Facial Mask Acrylic Cosmetic Display for Show Case. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

2019 Party DIY Smart Touch Screen Magic Mirror Photobooth.Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Light Roof Prefabricated Steel Structure for Parking.

12V torque DC gear motor for electric lawn mowers-Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). These measurements indicated fluidization difficulties with the wet cohesive granules,Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.

Acknowledgments

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