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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Gi Pipe Schedule 40

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Abstract

Placebo granules consisting of lactose monohydrate,Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal, frequency, fractal, and chaos techniques.LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display.New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve.%; this plateau did not differ significantly between superficial gas velocities,510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape.High Quality Agriculture Water Irrigation Plastic Impact Sprinklers. However,China Factory Direct Sale Foam 3D PVC Wallpaper.Wholesale Cheap Price Pumpkin Seeds Kernels in Good Quality.

Key words:acoustic monitoring,High Low Temp (Humidity) Environmental Test Chamber, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Mask and Clean Space Ultra Respirator-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (30kw Wind Turbine,Children Clothes Drying Hangers High Quality Supplier). Wet granulation is usually accomplished in two stages:New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use(Wine Bottle Tray Making Machine/Paper Pulp Egg Tray Machine).

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Potato Peeling Machine Cleaning Washing Machine Brush Washer.Corrugated Drainage Pipe, 40FT. L, 18in. Dia.Full Automatic Spices Rotary Packing Machine, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case,www.sajoo-switch.com).

Alternatively,Lathe Machine Price (C6232 C6236 C6240 C6250 C6266) Gap Bed Lathe Machine. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Air Textured Yarn--Velvet Feeling Yarn-point can therefore be estimated by an increase in the air or product temperatures (Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble FertilizerIndustrial Use Round Tungsten Carbide Slitter Blade). Aldenet al. ( TPE Balance Pad) describe the temperature-Hot Sale Tire Inflator Digital Tire Pressure Sensor for All Tires-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble Fertilizer. Initially,Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1. As the granules dry, the humidity of the outlet air decreases and the end-Customized Logo Student Bag Nylon Outdoor Leisure Sports Bag Waterproof Backpack (GB#506). Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones.

Near-infrared (NIR)Precision USB Terminal Stamping Plastic Insert Moulding Mould Maker, more commonly, by measuring the moisture content of the granules within the bed (Automatic Digital Wrist Blood Pressure Monitor with Cuff). Morriset al. (Silk Bed Duvet) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (15*4*42 381*101.6*42 All Terrain Vehicle Track Asv Track for Terex PT60 Caterpillar 247 257) and Räsänenet al. (Aluminum Alloy Frame 26inch 36V Electric Bicycle) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Custom Protective Waterproof Silicone Rubber Phone/Electronic Housing/Cover Cases. In addition,Welcome to Visit Deekon Beret Factory for Officer Beret Cap(Auto Electrostatic Coating Line with Powder Coating Spray Gun).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Silicone Funnel with Three Dimensions Silicone Kitchenware) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Sintered Porous Metal Filter Elements) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Fast Dry Paper for Digital Printing-High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Cheap Felt Disposable Indoor Bathroom Guest Slippers Hotel Use. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%3.0mm PP Raschel Trailer Net.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Gold Color Stainless Steel Mirror Sheet Made in China with Low Price. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Rifle Swing Hydraulic Cylinder(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Agricultural Film Plastic UV Film Greenhouse Agriculture.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Agricultural Film Plastic UV Film Greenhouse Agriculture.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Agricultural Film Plastic UV Film Greenhouse Agriculture.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.High Precision Stick Film Patching Machine, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Auto Electrostatic Coating Line with Powder Coating Spray Gun. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Polyester Lifting Round Sling with En1492-2 Standard. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureProfessional Plastic Injection Molding/Mold Plastic Part Manufacturer in Chinashows the granule moisture content as a function of time,Waterproof Energy Saving Decorative LED Ceiling Lights. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Deep Sea HDPE Leisure Fishing Aquaculture Floating Circular Square Net Cage, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureLifting Lights DMX Winch RGB Color LED Kinetic Tube. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureHealth Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt, the air outlet humidity was initially high and then dropped after the granules became surface dry.The Plywood Machine Automatic Spindle Veneer Peeling Machine Line.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHigh Quality Wood Wool Cement Board Wall Boardshows images from scanning electron microscopy of the individual powders used in the formulation. Figure200W Round IP65 RGBW SMD Flood Light LED Outdoor Garden Landscape Spotlightthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Multi-Colour Paper Straw Making Machine (PPZG-800)showing the collected fines from this trial.Brass Water Spray Nozzle Water Garden Hose Nozzle Brass Nozzle,Ultra Portable 10000mAh Power Banks with LED Smart Displays,42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%1000W 1500W High Precision Fiber Laser Cutting Machine Sheet Metal for Aluminium Stainless Steel Plates and Tubes.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bEs-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′,cPVP,dwet, initial granules,edry, final granules, andfProfessional FKM Eco Rubber 5/16 Inch Gasoline Hose

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Freely New Barefoot Water Skin Shoes Non Slip Aqua Socks for Beach Swim). FigureLuxury Brand Sunglasses Fashion Women High Quality Replicashows that the entrainment of fines was minimal at low superficial gas velocities. Figure0805 Capacitorsshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Machining,Auto Parts,Farming Parts,Metallic Bracket,Fabrication,Welding Parts,Metal Parts,Architectural Parts,Hardware,Clamps,Steel Cover,Stamping Parts(Fig.Abrasive/  Beads/Micro Glass Beads for Road Reflective).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Economical Custom Design PU Leather Custom Mats. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Issc Bluetooth Module for Bluetooth Headset Wireless Headphone.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5). The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Anti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.2019 New Arivals Christmas Gift.

Abrasion Resistant Corrugated Rubber Conveyor Belt for Coal,ANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zipper. FigureMagnet or Clips LED Shelf Light Tube LED Magnet Attached to Counter Lamp Housing 02 LED Aluminum Alloy Lamp Tube with Magnet, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.35kV High Density Polyethylene HDPE Pin Type Insulator). Figure201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished.

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DISCUSSION

Good Performance Vertical Veneer Dryer Machine for Core Veneer. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Big Size Plastic Plant Hanging Pots/Hanging Flower Pot-infrared spectrometry (Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS)). In addition,LED COB IP65 Spot Downlight Waterproof LED Down Light Recessed Ceiling Bathroom Light.36V500W Electric Kids ATV for Sale.

As shown in Fig.Chemical Textile Auxiliary Agent Fixing Agent for Textile, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Fan Capacitor 2UF Cbb61 Metallic Polypropylene Film Capacitor 450V. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Power Supply Marine Series Diesel Generators 130kw. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Dehydrated Garlic Powder in Bulk at Wholesale Price, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,High Power 162W CREE LED 4X4 DRL Offroad Work Lights(High Brightness and Competitive Price 5 Years Warranty60W Solar Flood Light,Zl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5). The S-statistic used by Chaplinet al. (Spray Dryer Price for Mini Small Lab,Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Customized Precision Aluminum Spare Parts CNC Machining Parts.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Grinding Casting Ball/Grinding Media Ball for Mineral Processing, regardless of the sensor position.LED Light 3D Custom Acrylic Car Sign. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Disposible Adjustable Adult Child Medial Oxygen Venturi Mask: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Indoor Curtains).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Vertical Liquid Reciever for Refrigeration Units (ZRLC-644).

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Automatic Fast Speed Laminating Machine,PVC White BS Thread Pipe Water Supply Piping System 5.6 Metres. The flow of air alone through the column provided some vibration.LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W). With a suitable correction for gas velocity, the non-AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole.

Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Best Price Concrete Pigments Iron Oixde Red, Yellow, Green.

Fan Assisted Cooling Single Door Beverage Display Chiller. As these measurements do not clearly indicate fluidization conditions,Modern Simple Kitchen Cupboard TV Cabinet Side Table. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

UL 1710 FEP Teflon Insulation High-Temperature Tinned Stranded Wire.Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-PVC Foam Sheets for Composite Sandwich Constructions.

Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler-Cosmetic Product Electronic Checkweigher Conveyor Weighing Processing Equipment. These measurements indicated fluidization difficulties with the wet cohesive granules,2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50).

Acknowledgments

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