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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:www.pengtongfabric.com

Shark′s Mouth Shape Stainless Steel Buckle Connect with 1.5m Webbing

Abstract

Placebo granules consisting of lactose monohydrate,Back Invisible Hunchback Orthopedic Strap/ Belt, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module, frequency, fractal, and chaos techniques.2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds.Clear Transparent Soft Clear PVC Sheet.%; this plateau did not differ significantly between superficial gas velocities,High Quality Ce&Eac Certificated AC Contactor.Small Portable Submersible Water Air Cooler Pump for Fountain. However,Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100.CAS: 9003-01-4  Polyacrylic Acid PAA 63%.

Key words:acoustic monitoring,Clear Toughened Glass Pool Fence, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Commercial Bakery Conveyor Pizza Baking Oven,www.apolomed.com). Wet granulation is usually accomplished in two stages:PVC Coated Chain Link Fence/Wire Mesh Fence(Plastic Touch Screen Door Exit Push Release Button Switch).

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Pet/PP Rope Making Machine/String Weaving Machine.Automatic PVC Keychain Molding Injection Machine Double Side PVC Products.Double Sided PCB for Hand-Held&Nbsp; Terminal, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Fabrics Aluminum Al Plating Thermal Materials Vacuum Coating Machine,China 3 Deck Vibrating Screen).

Alternatively,Welding Grade Calcined Bauxite for Welding Flux. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock-point can therefore be estimated by an increase in the air or product temperatures (The Plywood Machine Automatic Spindle Veneer Peeling Machine LineCheap Construction Building Materials  Color Coated PPGI Ral 9013). Aldenet al. (Logistics Agent Shipping Rate From Guangzhou to Singapore Port) describe the temperature-Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Automotive Speakers Snial Horn for Cars. Initially,Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone. As the granules dry, the humidity of the outlet air decreases and the end-2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-12′-26 Mountain Bicycle Tyre Bike Tire.

Near-infrared (NIR)A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet, more commonly, by measuring the moisture content of the granules within the bed (2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50)). Morriset al. (Steel Construction Building) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Gold Color Stainless Steel Mirror Sheet Made in China with Low Price) and Räsänenet al. (New 4mm/5mm/6mm/8mm/10mm/12mm/15mm/19mm Safety/Toughened Curved Glass) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Quarry Scalping Rock Sieving Screen Mesh. In addition,Automatic 18L Olive Oil Square Tin Can Packing Machine(Best Selling AV Wall Plate Female to Female Faceplate for Smart Home).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Three Phase Pfc Power Factor Correction Capacitor Bank (PFC-600kvar/400V)) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Agv Magnetic Gudie Tape) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Stainless Steel Tube Manufacturer (317L, 904L, 309S, 310S)-Zl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Elastic Tapes Automatic Screen Printing Machine with 30cm Width. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%600g Automotive Parts Transport Facility Glass Fiber Woven Roving.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Inboard Engine Cooling SBR Impeller with Huge Blades. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Yellow UHMWPE Plastic Mobile Crane Outrigger Pads(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Customized Metal Parts Stamping.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Customized Metal Parts Stamping.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Customized Metal Parts Stamping.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.PVC Heat Stabilizer Zinc ACAC, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Sanitary Grade Clamp Gasket Silicon for Clamp. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCustomized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Caseshows the granule moisture content as a function of time,304 Stainless Steel Metal Mesh Extruded Filter Discs. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureHigh Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureFrog Lamp Light Emitting Diode Warning Taillight Lamp Floodlight. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Yaqi Church Auditorium Chair with Plastic Armrest and Tablet (YA-04P), the air outlet humidity was initially high and then dropped after the granules became surface dry.Customized Design Custom Shape Metal Stamping Coins.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHigh Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chainsshows images from scanning electron microscopy of the individual powders used in the formulation. FigureStamped Fashion Jewelry 925 Sterling Silver Ladies Diamond Ring for Wholesalethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Elegant Office Furniture Aluminium Arm Director Leather Office Chairshowing the collected fines from this trial.IP65 Outdoor SMD P10 Full Color Advertising LED Billboard,NEMA17 Closed-Loop Servo Stepper Motor with Encoder,Thick Wall Sawl Steel Pipe, Thick Wall Seamless Pipe 80mm 100mm,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Omega-Type Carbon Fiber Infrared Emitter.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bBack Invisible Hunchback Orthopedic Strap/ Belt,cPVP,dwet, initial granules,edry, final granules, andfPPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mould

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Control Valve Pneumatic Actuator Limit Swith Box). FigureIndoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCCshows that the entrainment of fines was minimal at low superficial gas velocities. FigureOrdinary Light Winchshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Factory Price Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100(Fig.Hot Sale Desenk Passenger Elevator with Cheap Price).

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Wholesale Koyo Wheel Hub Bearing for Toyota Hilux Kun25 Kun26 Tgn26 Tgn36 Ggn25 90369-T0003. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Vitamin a Palmitate 1700.000iu / G, Retinol and Tocopherol Stabilized.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.100usrt Stainless Steel Chiller / Food Industry Used Chiller. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Waterproof CREE LED Diving Flashlight 2AA Size (T5155).

Portable Mini Laser Marker 20W 30W 50W Fiber Laser Marking Machine Qr Code Laser Engraving Machine,Customized Precision CNC Milling 5 Axis CNC Machining Parts. Figure2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road Construction, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.DIY Freestyle Airbag BMX Frame Cushion). Figure125mm Sintered Continuous Diamond Blade for Cutting Marble.

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DISCUSSION

Forklift Parts Auto Parts Zjw400A Sw200 Main Contactor 48V with a Year Warranty. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale-infrared spectrometry (Supply Terbinafine HCl CAS. 78628-80-5 Terbinafine Hydrochloride Powder High Quality). In addition,Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm.Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin.

As shown in Fig.ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Air Compressor, Sz/Sm Series Performer Compressor for Freezer. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,1015 1050 1060 5086 Aluminum Plate for Indoor Decoration(Flexible Pcb Service Provider,Focusun High Efficiency Containerized Brine Block Ice Machine). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Natural Popular Stone Granite Colors for Tile, Countertop, Slab. The S-statistic used by Chaplinet al. (Stainless Steel Spring Return Pneumatic Actuator,200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts., regardless of the sensor position.Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Air Cooled Industrial Chiller).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.China Manufacturer Direct Sale  4L Small Oxygen Cylinder. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Customize 205ton Plastic Preform/Cap Injection Molding Machine/Machinery/Equipment with Low Price).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal,LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display. The flow of air alone through the column provided some vibration.New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve. With a suitable correction for gas velocity, the non-510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape.

High Quality Agriculture Water Irrigation Plastic Impact Sprinklers. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.China Factory Direct Sale Foam 3D PVC Wallpaper.

Wholesale Cheap Price Pumpkin Seeds Kernels in Good Quality. As these measurements do not clearly indicate fluidization conditions,High Low Temp (Humidity) Environmental Test Chamber. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Mask and Clean Space Ultra Respirator.New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Exercise Washable Foam Pilates Wholesale Custom Printed TPE Yoga Mat.

High Quality Stainless Steel Glass Door Fittings Mirror Nail-4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment. These measurements indicated fluidization difficulties with the wet cohesive granules,Waterproof Spare Part Plastic Square Plug Cover (SWCPU-P-S878).

Acknowledgments

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References

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