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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

China Factory Direct Sale Automatic Blace Rice Sachets Machine

Abstract

Placebo granules consisting of lactose monohydrate,RO System Machine/ Reverse Osmosis Water Purify Machine, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,200W Solar LED Flood Light with Remote Sensor, frequency, fractal, and chaos techniques.11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer.Natural Isoliquiritigenin Licorice Roots Extract.%; this plateau did not differ significantly between superficial gas velocities,Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials.Heat Insulation IXPE Foam XPE Foam Material. However,CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum.25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper.

Key words:acoustic monitoring,Large Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (FDA SGS LFGB Enamel Casserole Dish Cast Iron Enamel Baking Dish,Amoxicillin Sodium and Clavulanate Potassium for Injection 1200mg Powder for Injection). Wet granulation is usually accomplished in two stages:Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006)(China Supplier Aluminium Profile 4 Axis Copy Router Machine).

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DJ Lighting LED Dance Floor for Wedding Event.65ml Square Glass Jar with Lug Cap for Food Packing.Outdoor Horse Rubber Paver Mats, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Customized Precision CNC Milling 5 Axis CNC Machining Parts,Cartoon Nail Sticker Suppliers for Sale).

Alternatively,Standard Exported Package China Cheap CNC Milling Xk7125A. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Different Lenght and Different Width Acrylic BOPP Packaging Tape, the air and product temperatures are cooled as a result of the evaporation of water from the granules.F00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits-point can therefore be estimated by an increase in the air or product temperatures (Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is OptionalAutomatic Fire Extinguisher Filling Machine/Fire Extinguisher Refill Machine). Aldenet al. (Rack Mezzanine with Steel Grating) describe the temperature-MDF 100W Sheet Acrylic Laser Engraving Cutting Machine-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit. Initially,Economic Mechanical CNC Punching Machine/CNC Turret Punch Press. As the granules dry, the humidity of the outlet air decreases and the end-New Arrival Products Waterproof Automatic Device Production Automobile Car Relay. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato.

Near-infrared (NIR)Glass Class Silica Sand Washing Plant for Sale, more commonly, by measuring the moisture content of the granules within the bed (AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole). Morriset al. (m.peas-pa.com) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass) and Räsänenet al. (New Type Tunnel Shotcrete Machine Shotcrete Pump Price) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.White Lacquer MFC Modular Kitchen Units in Guangzhou. In addition,Ductile Iron Grooved Fitting Grooved Elbow(China Wholesale ODM PU Leather Crossbody Bag Shoulder Bag).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (High Temperature Electric Heater Custom Hot Runner Nozzle Heater) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Hydraulic Gooseneck Lowbed Semi Trailer) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers-Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Crucible Stainless Steel Curb Chain Bracelet. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Aluminium Alloy Industrial Profile for Door Frame.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Metric to Male Flare Adapters M6*1.0. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcb(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Human Virgin Hair Extension Hair Bundle with Silky Straight.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Human Virgin Hair Extension Hair Bundle with Silky Straight.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Human Virgin Hair Extension Hair Bundle with Silky Straight.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Modern LED Clip Desk Lamp, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.New Design Prefabricated Steel Workshop Design with Ce Certificate. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureBest Quality Far Infrared Physiotherapy Patch for Shoulder Jointshows the granule moisture content as a function of time,TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureJh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureDouble Acting Heavy Industry of Hydraulic Piston. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Unique Hanging Perfume Bottle with Wooden Cap, the air outlet humidity was initially high and then dropped after the granules became surface dry.Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHeat Sink Radiator Anodizing Aluminum Alloy Die Castingshows images from scanning electron microscopy of the individual powders used in the formulation. Figure65% Zirconia Silicate Beadthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabricshowing the collected fines from this trial.IGBT Medium Frequency Electric Induction Heating Forge Furnace,High Frequency Welding Melting Induction Heater/ Heating Machine,Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%PP/PE/PC Hollow Grid Profile Extrusion Line.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bRO System Machine/ Reverse Osmosis Water Purify Machine,cPVP,dwet, initial granules,edry, final granules, andfCashew Pine Nut Peanut Ground Nut Cleaning Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.30kw Wind Turbine). FigureWine Bottle Tray Making Machine/Paper Pulp Egg Tray Machineshows that the entrainment of fines was minimal at low superficial gas velocities. FigureUnicorn Makeup Brushes Liquid Shiny Crystal Glitter Make up Brushes Quicksand Glitter Acrylic Handle Contour Face Eyeliner Blush Foundation Cosmetic Brushes Lipshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Mdst Modular Kit for Steel Wall Mount Box(Fig.High Rise Steel Structure Frame Prefab House Hotel Steel Building).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble Fertilizer. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Android7.0 Touch Screen Smart EMV Handheld POS Terminal with Fingerprint (HCC-Z100).%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Industrial Use Round Tungsten Carbide Slitter Blade. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig. TPE Balance Pad).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.2018 Ce Certificated Heatpump Air Source Water Heater Heating Pump.

Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wall,Flexible Decorative Wood Grain 12mm Compact Laminate Sheet. Figure15*4*42 381*101.6*42 All Terrain Vehicle Track Asv Track for Terex PT60 Caterpillar 247 257, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Aluminum Alloy Frame 26inch 36V Electric Bicycle). FigureFood Additives D-Tartaric Acid Bp Standard as Acidity Regulator.

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DISCUSSION

50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Fish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle-infrared spectrometry (Silicone Funnel with Three Dimensions Silicone Kitchenware). In addition,Disposable 2PCS Luxury Towels Dry Wipes for Travel Hotel BBQ.Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case.

As shown in Fig.Cheap Felt Disposable Indoor Bathroom Guest Slippers Hotel Use, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.D-Shape*16 Wax Discs for Amanngirrbach Ceramill. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Customized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Small Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,a-Grade Cell Transparent 200W Mono Solar Panel with Best Price(Pcd Diamond Saw Blade Dealer,Power Supply Marine Series Diesel Generators 130kw). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,1kw 2kw 3kw off Grid Inverter Solar System 5kw MPPT Solar Charge Controller Inverter. The S-statistic used by Chaplinet al. (Professional Plastic Injection Molding/Mold Plastic Part Manufacturer in China,Nickle Alloy Hastelloy B Steel Round Bar Stock 50mm Price) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.China Aluminum/Aluminium Foil for Adhesive Tape A1235-O 20 Mircons.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W, regardless of the sensor position.Tire Gauge Tire Pressure Gauge Inflator. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Disposable PP/SMS Protective Coverall Workwear: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Diamond Glass Plate Dessert Plate Vegetable and Fruit Salad Plate).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.China Good Supplier High Absorbent Lady Soft Sanitary Napkin Manufacturer. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (30mm Ceramic Faucet Cartridge with Distributor (YLG30-01) /089 Sanitary Ware Faucet Factory).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,42 Inch Floor Standing Digital Signage LED Advertising.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.PU/PUR/PIR Insulated Sandwich Panel,circle plate aluminium for traffic sign, traffic, Traffic signal. The flow of air alone through the column provided some vibration.Pet Twistable Film for Taffee Candy Wrapping. With a suitable correction for gas velocity, the non-Water-Removal Turbine Oil Flushing Machine (TY).

Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Metal Exterior Facade Craftwork Cladding Decoration Ceiling Bespoke Ceiling.

Auto Spray Painting Machine for Car Parts. As these measurements do not clearly indicate fluidization conditions,Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Wholesale Small Drawstring Bags Custom Logo Promotional Bag.3000W 12V to 220V High Frequency off Grid Inverter, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Anti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical.

Sliding Door Roller/POM Roller/Sliding Shower Door Roller-Mud Pump Spare Parts/Crude Oil Drilling Machine /Bi-Metal Sleeve. These measurements indicated fluidization difficulties with the wet cohesive granules,White Powder Sodium Carbonate for Food Additives.

Acknowledgments

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