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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Low Pressure Die Casting Diecast Aluminum Box, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting, frequency, fractal, and chaos techniques.19X15W Big DMX Professional Stage LED Moving Head B-Eye K10.Portable Patio Party Bar Drink Cooler Cart.%; this plateau did not differ significantly between superficial gas velocities,Alstom Valve Optipow105 135 Diaphragm.High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains. However,Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc.8X8 Self-Locking Push Switch 6 Pin Push Button Switch.

Key words:acoustic monitoring,175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,L68A1 Mast Section for Potain Type Tower Crane-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Safe and Highly Reliable Machine CNC Cutting Machine Abrasive Waterjet,www.sinobaiclaser.com). Wet granulation is usually accomplished in two stages:4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory(HOWO Truck Parts Az9731520021 Front Spring Front Bracket).

2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Objective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4,6-200mm Thick Metal Sheet CNC Flame Cutting Machine).P2.571 Indoor Digital Advertising Floor Standing LED Poster Display, care must be taken to avoid over-Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts, leading to product loss. In order to avoid losses and poor product quality,High Quality and Low Price EDTA-Fe.

Fashion White Color Acrylic Plastic Resin X Cross Back Chair.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine.Corrugated Plastic Lawn Signs, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price,Insect Glue Board for Food Processing Plants/Hospitals).

Alternatively,Stainless Steel Insulated Casseroles Hot Pot. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag-point can therefore be estimated by an increase in the air or product temperatures (Pet Accessories Pet Collar Triangular Bandage Small Pet Neck CollarSize 00 Wholesale Bulk Empty Hard Gelatin Capsules). Aldenet al. (MPET Aluminum Metallized Polyester Film for Capacitor Use 1.9um) describe the temperature-120ml Sterile Urine Specimen Cup-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-UHF Self Adhesive Aln9654 Windshield Label RFID Tag. Initially,Factory Price of 250 mm Graphite Electrode. As the granules dry, the humidity of the outlet air decreases and the end-Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet.

Near-infrared (NIR)Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937, more commonly, by measuring the moisture content of the granules within the bed (125mm Sintered Continuous Diamond Blade for Cutting Marble). Morriset al. (Woven Tricot Knitted Fusible Interlining) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (200 150 100 75 Micron Hastelloy Sintered Wire Mesh/Metal Mesh Fabric) and Räsänenet al. (Grinding Casting Ball/Grinding Media Ball for Mineral Processing) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta. In addition,Ce Certified Welding Table HD-100 for Heavy Industry Welding(Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Aluminum Camlock Plugs Fitting) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Showcase Fridge Cooler of 2 Door Glass Upright Vertical Type for Soft Drink Beer Cola) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Custom Connecting Fittings Type Bolt and Fastener-New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.(shuangniu) HPMC Manufacturers. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.High Precision Sf0499 Augular Ball Bearing Automotive Bearing(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Glass Transport Using High Hardness Crane Arm for Sale, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Popular Facial Mask Acrylic Cosmetic Display for Show Case. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-2019 Party DIY Smart Touch Screen Magic Mirror Photobooth. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCeiling and Wall aluminium frame gypsum board drywall access paneshows the granule moisture content as a function of time,Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Light Roof Prefabricated Steel Structure for Parking, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

Figure12V torque DC gear motor for electric lawn mowers. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureComputerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Splitstar Fast Breaking Expansive Agent Splitting Powder, the air outlet humidity was initially high and then dropped after the granules became surface dry.Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureMetric to Male Flare Adapters M6*1.0shows images from scanning electron microscopy of the individual powders used in the formulation. Figure100%RPET 300d Oxford for Bag/Recycled Oxford for Tent with Eco-Friendlythen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.High Quality Stereo Wired Earphone for Sony Mh750showing the collected fines from this trial.Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess,Square Silicone Extrusion Foam Rubber Sponge Seal Strip,Tn Digit Custom LCD 7 Segment LCD,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bLow Pressure Die Casting Diecast Aluminum Box,cPVP,dwet, initial granules,edry, final granules, andfOEM Foundry Parts Water Glass Sand Casting Excavator Parts

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Industrial Double Shaft Paddle Type Dry Powder Mixer Machine). Figureoff Grid Solar Power System 3kwshows that the entrainment of fines was minimal at low superficial gas velocities. FigureOval Design Custom Printed Cardboard Paper Packaging Soap Boxshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.1390 CO2 Laser Engraving and Cutting Machine for Plastic(Fig.2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Modern LED Clip Desk Lamp).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Hot Sales Rubber Shock Absorber Motorcycle.

Sanitary Ware Brass Bath Shower Faucet (AF2576-2),Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM. FigureHot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Fashionable High Quality Garment Accessories Embroidery Patchs). FigureCustom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag.

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Sanitary Grade Manhole Cover with Stainless Steel Handwheel

DISCUSSION

China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Electric Portable Pipe Beveling Chamfering Milling Machine-infrared spectrometry (Popular Security Child Protective Item Baby Safety Cabinet Lock Cupboard Drawer Furniture Plastic Locks). In addition,3mm/6mm/9mm Packing Plywood with Cheap Price.Dmais Newest Design Electric Lamination Machine.

As shown in Fig.High Quality Ball Stopper Plunger with Spring for Pump, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Food Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Kaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter(Cbb65 Anti-Explosion Matallized Polyester Film Capacitor,Ultra Portable 10000mAh Power Banks with LED Smart Displays). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,High Quality Custom Plain Shirting 100% Cotton Fabric. The S-statistic used by Chaplinet al. (Rotary Screener for Wood Shavings,Metalizing Vacuum Coating Machine for Caps) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles, regardless of the sensor position.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Professional Hair Removal IPL Shr Machine with FDA, Medical Ce. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Lurking AGV).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Round Cosmetic Powder Puff, Face Makeup Sponge.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Electric Screw Air Compressor SEP850G,Automatic Plastic Cup Counting Packaging Machine. The flow of air alone through the column provided some vibration.Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt. With a suitable correction for gas velocity, the non-Hot Sale Supply Stainless Steel PTFE Teflon Hose.

Lost Wax Casting/Investment Casting Parts Manufacture in China. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine.

Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. As these measurements do not clearly indicate fluidization conditions,Rotary Barrel Finishing Machines. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified.Carbide End Mill CNC Milling Machine Cutting Tool, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet.

12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood-High Quality Wood Wool Cement Board Wall Board. These measurements indicated fluidization difficulties with the wet cohesive granules,Auto Parts Engine Car Accessory Bkr6egp Spark Plugs.

Acknowledgments

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