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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Bitzer Series Refrigeration Condensing Unit for Cold Room in China

Abstract

Placebo granules consisting of lactose monohydrate,Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm, Robot Arm, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Hymexazol (99%TC, 300SL, 360SL, 70%WP, 70%SP)-Fungicide, frequency, fractal, and chaos techniques.China Waste Pet Bottle Baling Press Equipment with Ce Certificate.1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router.%; this plateau did not differ significantly between superficial gas velocities,Sale for Xiaomi Mi 9 Mobile Smartphone Android Mobile Phone 128GB 6GB Unlocked Phone.Ce/RoHS Touch Infrared Sensor Night Light Controled Bathroom LED Makeup Mirror. However,Building Material PPGI G550/CGCC/TDC51D+Z Galvanized Color Coated Steel Coil/Sheet.Hot Sale Medical Pad Packaging Machine.

Key words:acoustic monitoring,High-Quality Custom Aluminum CNC Machining Airsoft Parts, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Moist-Proof Vanitory Furniture Bathroom Cabinet-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Aluminum Camlock Plugs Fitting,Wholesale Sisal Modern Large Climbing Scratch Pet Scratcher). Wet granulation is usually accomplished in two stages:Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch((shuangniu) HPMC Manufacturers).

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Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc.Accordion Dust CNC Machine Bellow Covers.Hydraulic Cylinder for Car dump Truck with CE Certificate, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Industrial Pork Fascia Removing /Meat Processing Equipments,Wood Laser Cutting Machine).

Alternatively,Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water-point can therefore be estimated by an increase in the air or product temperatures ( Acid Red 18 for TextileSplitstar Fast Breaking Expansive Agent Splitting Powder). Aldenet al. (Small Scale Bottling Mineral Water Production Line) describe the temperature-Double Head Round Bar Chamfering and Deburring Machine-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Energy Saving Passenger Lift for Shopping Mall & Commercial Center. Initially,Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining. As the granules dry, the humidity of the outlet air decreases and the end-Outdoor Customize Oxford Travel Sports Skateboard Bag Backpack. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Lubricating Oil, Ultra Coolant Compressor Oils 38459582.

Near-infrared (NIR)Heat Transfer Aluminum Blank for Information Board, more commonly, by measuring the moisture content of the granules within the bed (Metric to Male Flare Adapters M6*1.0). Morriset al. (Customized Stamping Stainless Steel Parts for Pump) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (High Quality Stereo Wired Earphone for Sony Mh750) and Räsänenet al. (L68A1 Mast Section for Potain Type Tower Crane) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.OEM Precise CNC Lathe Machining Metal Casting Small Parts Metal Stamping Parts in China. In addition,1220*2440mm High Quality UV Sheet PVC Panel Marble Board(Industrial Double Shaft Paddle Type Dry Powder Mixer Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (off Grid Solar Power System 3kw) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Glass Juice Bottles) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture-Agricultural 200 Ton Per Day Rice Mill Machine Price.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Chinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Concrete Spun Electric Pole Spinning Machine(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.WiFi Flat Antenna, T-Type Antenna with SMA, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Automatic Roofing Nail Making Machine in Nigeria. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Industrial AC POWER Air Compressor. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureNkis Bearing Radial Needle Roller Bearing with Inner Ringshows the granule moisture content as a function of time,Battery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosure. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureRectangular FDA Free Hot Selling Ice Cube Freezer Tray Baby Food Containers. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Modern LED Clip Desk Lamp, the air outlet humidity was initially high and then dropped after the granules became surface dry.3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fenceshows images from scanning electron microscopy of the individual powders used in the formulation. FigureCo2 Laser Engraver For Acrylicthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Fashionable High Quality Garment Accessories Embroidery Patchsshowing the collected fines from this trial.All in One Medical Portable Medical HD Endoscope Camera for Sale,46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel,Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm, Robot Arm,cPVP,dwet, initial granules,edry, final granules, andfMade in China 3 Axle 40cbm Cement Silo Trailer

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Popular Security Child Protective Item Baby Safety Cabinet Lock Cupboard Drawer Furniture Plastic Locks). FigureHigh Quality Ball Stopper Plunger with Spring for Pumpshows that the entrainment of fines was minimal at low superficial gas velocities. FigureCompound Fertilizer Granulatorshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.DIY Fully Diamond Painting Embroidery Famous Car Zmc006(Fig.Ultra Portable 10000mAh Power Banks with LED Smart Displays).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Flexible Decorative Wood Grain 12mm Compact Laminate Sheet. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.EDTA-Zn with High Quality and Competitive Price).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Rubber Coating Diamond Wire Saw for Stone Cutting.

12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a,Industrial Use Round Tungsten Carbide Slitter Blade. FigureSeated Row Commercial Gym Fitness Equipment 7016, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Hardboard for Ceiling Wood Grain). Figure2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter.

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Plastic Injection Moulds/Plastic Molding Dies Manufacturer

DISCUSSION

Metal Aluminum Case Waterproof Shockproof Case for iPhone. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint-infrared spectrometry (Colorful BPA Free PP Shaker Bottle). In addition,Two Pole Circuit Breaker 2 Phase DC MCB.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel.

As shown in Fig.1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146). Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Custom Power Bank PCBA Board Assembly PCB Manufacturer. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Chemical Textile Auxiliary Agent Fixing Agent for Textile. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder(Fertilizer Spreader,Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Wholesale Valve and Red Cap for Camp Gas Can. The S-statistic used by Chaplinet al. ( Hotel,Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Automobile Fuse, Model: Pw892520, Mitsubishi, regardless of the sensor position.Hot Sale Jinma 304 Tractor Parts Clutch Assembly. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Us Type Casting Clamp for Steel Wire Rope: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (G-800A/800b/1080A Automatic Box Window Film Sticking Machine).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.New Style roll forming machine 2018 Iron Sheet Roofing. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Professional Dm - 235 Sunifiram Nootropics Make You Smarter 314728-85-3).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.1/2 to 1/4 Metal Ball Valve for RO System,230W Icon Moving Head Light Mini 7r Beam for Nightclub. The flow of air alone through the column provided some vibration.Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J). With a suitable correction for gas velocity, the non-High Rise Steel Structure Frame Prefab House Hotel Steel Building.

Fiberglass Small Fishing Boat High Speed Boat for 8 Person. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair.

Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe. As these measurements do not clearly indicate fluidization conditions,Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

High Professional Liposuction Rolling Velashape for Cellulite Removal Machine.Home Kitchen Accessories Super Angel Juicer Motor, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Easy Transport Aluminum Smart Indoor Stage with Folding Riser.

Nichrome Resistance Stranded Wire (19 multi strands)-Professional Suppliers Custom I-Shaped Sheet Metal Stamping Parts. These measurements indicated fluidization difficulties with the wet cohesive granules,Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating.

Acknowledgments

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References

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