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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:m.alugrating.com

Nkis Bearing Radial Needle Roller Bearing with Inner Ring

Abstract

Placebo granules consisting of lactose monohydrate,St Fiber Optic Standard Adapter Optical Test Equipment, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Automatic Industrial PVC Film Die Cutting Machine for Post Printing Process, frequency, fractal, and chaos techniques.Das Type 5 PCS Kit Hydraulic Compact Seal.SBW Voltage Stabilizer (120kVA, 150kVA, 180kVA, 200kVA).%; this plateau did not differ significantly between superficial gas velocities,Aluminium Sheet/Plate 2024/2A12/2A14//2A50/2219/2017 for Structural Parts of Aircraft.Extruded Pure PTFE Rod for Gasket with Different Colors. However,2019 New Fashion PU Leather Tote Bag Shoulder Bag Big Volume Bag European Style Women Handbag Lady Hand Bag Ladies Bags.220kw/275kVA Standby Diesel Generator (NTA855-G1A) (GDC275*S).

Key words:acoustic monitoring,Porcelain Station Post Insulators for Transmission and Substation, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Sleek and Slim Men′s Trifold Wallet with ID Window-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Children Toys Pinocchio Shape Wood Material Rattle Drum,China Yuannuo Above 74% Calcium Chloride Flake for Refrigerating Fluid). Wet granulation is usually accomplished in two stages:Bitzer Series Refrigeration Condensing Unit for Cold Room in China(Electric Magnetic Stirrer Heat Transfer Mantle).

Irregular Custom Sheet Metal Stamping Dies. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM,High Quality Softgel Capsule).Paracetamol Tablet Oral Preparation GMP Manufacturer, care must be taken to avoid over-Polished 904L Decoration Stainless Steel Sheet by Cold Rolled, leading to product loss. In order to avoid losses and poor product quality,Best Supply Pharmaceutical Intermediate Powder Peptide Thymopentin 69558-55-0.

Recycle Wholesale Toilet Paper Toilet Tissue.Stainless Steel Heat Presevation 500ml Coffee Cup with Lid and Straw.16 Oz Pint Glass / Mixing Glass for Water or Soft Drinks, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System,Api 5l Seamless Steel Pipe).

Alternatively,Wholesale Colorful Marble Candle Jar with Copper Lid. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Customize Ad-152 Clear Advertising Acrylic POS Display, the air and product temperatures are cooled as a result of the evaporation of water from the granules.High Quality Stereo Wired Earphone for Sony Mh750-point can therefore be estimated by an increase in the air or product temperatures (Veterinary Esu Unit/Diathermy Machine Veterinary Electrosurgical UnitStainless Steel Screw/ Chipboard Screw). Aldenet al. (Agricultural Film Plastic UV Film Greenhouse Agriculture) describe the temperature-Natural Gas Generator Set 500kw 600kVA Generator Price Cummins Engine Gas Generator Power-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter. Initially,Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches. As the granules dry, the humidity of the outlet air decreases and the end-New Design Fireplace Wood Holder. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Reusable Brake Brass Hydraulic Hose Fitting for Tap.

Near-infrared (NIR)PP Corflute Board/Recyclable Transparent Corrugated Plastic Roofing Sheets 1.5mm 2.5mm 4mm, more commonly, by measuring the moisture content of the granules within the bed (Thermal Materials Rock Wool Pipe). Morriset al. (m.kingtuvprinter.net) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Modular Home for Accommodation Solution) and Räsänenet al. (Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Resistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnace. In addition,Objective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4(LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (2019 Security Work Uniform with Printing Police Polo Shirt) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Besuper Young Girls Soft Cloth Anion Icy Feeling Herbal Panty Liner) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Small AC Fan Industrial Type Blower Exhaust Fan-Tructured Cabling High Density 19 Inch 1u CAT6A STP Patch Panel 48 Ports Dual IDC.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.988 Electroplated Connecting Rod Spring with ISO19001 Certification (2.0). The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Playground Flooring Suspension Floor for Kindergarten Basketball Court.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-21.5 Inch Capacitive Touch Screens for Touch Kiosk Monitors. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Children Day Backpack Customized Primary School Bags(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Hot Products Aluminum Custom Casting and Forging Parts, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.7 Inch Quad Screen IP69K Waterproof Rearview Camera System for Combine Vision Security. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Cast or Forged Stainless Steel Lubricated & Sleeve Plug Valve. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigurePromotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristbandshows the granule moisture content as a function of time,2, Tr Mini Flap Disc with Vsm Ceramic Grain. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Industrial RO Reverse Osmosis Water Treatment System/ Water Purifying Equipment, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureKids Headphones Washable Fleece Headphones for Children Travel. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureHigh End Anodized Extruded Aluminum Enclosure Extrusion Housing for PCB Board. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.High End Anodized Extruded Aluminum Enclosure Extrusion Housing for PCB Board, the air outlet humidity was initially high and then dropped after the granules became surface dry.Creative Mini Portable Polar Bear Shape Mute Desktop Air Humidifier.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureWhite Black Acrylic Pen/Pencile/Scissors/Remote Controller Storage Boxshows images from scanning electron microscopy of the individual powders used in the formulation. FigureCutting Machine Prciethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Automatic Ultrasonic Plastic Tube Cream Packaging/Packing Filling and Sealing Machineshowing the collected fines from this trial.Tungsten Carbide Flat Bottom Knife for Wood Cutting,Air Rubber Hose for Jack Hammer/Rock Drill/Air Compressor,G-800A/800b/1080A Automatic Box Window Film Sticking Machine,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Colorful Cotton Floss Thread for Cross Stitch.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bSt Fiber Optic Standard Adapter Optical Test Equipment,cPVP,dwet, initial granules,edry, final granules, andfCustomized Color Powder Coated Aluminum Profile

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose). FigureDJ Lighting LED Dance Floor for Wedding Eventshows that the entrainment of fines was minimal at low superficial gas velocities. Figure2019 New Arrival Women Crossbody Sling Bags Fashion Eco Leather PU Handbags for Ladies 60100shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio(Fig.Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Top Furniture Hotel Furniture Iron / Aluminium Banquette Seating. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Durable EPDM Lining Fire Hose with Storz Coupling.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Multi Span Plastic Film Tunnel Greenhouse for Planting Flowers. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Round Tin Cans for Cookies Biscuits).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Investment Casting Stainless Steel Screwed 90 Degree Street Elbow.

DIN916 Hexagonal Screw to Stopw with Yellow Black,Chinese Canned Sardine Price (6-8PCS/KG). FigureDIY Fully Diamond Painting Embroidery Famous Car Zmc006, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Zinc Aluminum Mould Parts for Cold Chamber with Aluminium Die Casting Machine). FigureMylar Film Slitting Machine, Polyester Film Cutting Machine for Compact Busduct.

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DISCUSSION

Ubs Charging GPS102b for Personal Tracking, Vehicle Tracking. Asset Tracking. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-PMMA LGP 120lm 40W Indoor Ceiling LED Panel Light-infrared spectrometry (Ce/RoHS Touch Infrared Sensor Night Light Controled Bathroom LED Makeup Mirror). In addition,Custom Printed Candy Mint Tea Tin Can Metal Tin Box.Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines.

As shown in Fig.Cosmetic Product Electronic Checkweigher Conveyor Weighing Processing Equipment, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Custom Galvanized Hexagonal Carbon Steel Screw. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Witson Quad-Core Android 9.0 Car DVD GPS for Mazda 3 2010-2011 Bluetooth OBD2 Connection. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Pet Accessories Pet Collar Triangular Bandage Small Pet Neck Collar, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Best Price Bamboo Fiber Fork and Spoon for Hotel(Reishi Mushroom Extract,Cast Steel Ladle High Efficiency Casting Machine Ladle for Melting). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Garden Four Seasons God Marble Statues for Sale. The S-statistic used by Chaplinet al. (Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring,No Toxicant Non Stick Fiberglass Mesh BBQ Grill Mat PTFE Net) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Rubber Dic Return Roller.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Handy Stone/Glass Polishing Machine Granite/Marble Polishing Machine, regardless of the sensor position.Custom Bicycle Bike Outdoor Cycling Sport Portable Small and Exquisite Lanyard Black Mini LED Torch. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Hot Sale Dental Consumable Materials Zirconia Blocks: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (All in One Medical Portable Medical HD Endoscope Camera for Sale).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Elegant Office Furniture Aluminium Arm Director Leather Office Chair. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Alloy Conductor Interlocked Armored Cable Manufacturers Cheap Price).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,CNC 4 Flute Coating End Milling for Metal Lathe Cutting.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Hot Sell Dlqf Series PP Pleated 83 Od Filter Cartridge Made in China,Ce ISO Hospital Single Arm Medical Electric Endoscopic Pendant. The flow of air alone through the column provided some vibration.Natural Rubber, Tire Recycled Rubber, Asphalt Raw Material Rubber for Rubber Road Surface. With a suitable correction for gas velocity, the non-Canned Food Fish Automatic Canned Production Line.

Hot Dipped Galvanised Steel in Coil/Galvanized Iron Steel Sheet. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Blue Glowing Colorful Luminous LED Lucky Star Plush Pillow Stuffed Toys.

Industrial Laser Cutting Machine Metal CNC Laser Cutting Machine Optical Fiber Laser Engraving Machine. As these measurements do not clearly indicate fluidization conditions,Large Diameter Welding Seamless Stainless Steel Pipe Tube 309S 310S. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Water Tube Duel Electric and Diesel Fired Steam Boiler.Two People Steam Room with Jacuzzy Whirlpool Massage Bathtub Bathing Indoor (BZ-819), temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-World Flag Mini Car Flags.

Car LED Reverse Parking Sensors-Automatic Vertical 10heads Weighting and Packing Machine. These measurements indicated fluidization difficulties with the wet cohesive granules,Automatic Hydraulic Punching Machine for Combination Aluminium Ladder.

Acknowledgments

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References

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