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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Aluminum Bending Die Casting Parts for Machine

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Abstract

Placebo granules consisting of lactose monohydrate,Best Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,6mbp75ra060 IGBT Modules Mosfet Power Modules Electronic Fujitsu Modules Original and New in Stock, frequency, fractal, and chaos techniques.Good Quality ASTM Standard 2017A Aluminium Alloy Plate.Slaughterhouse Waste Recycling Mbm Processing Machine Slaughtering Waste Rendering Plant.%; this plateau did not differ significantly between superficial gas velocities,Stable Single Screw Plastic Flakes Recycling and Pelletizing Extruder.Commercial Bakery Conveyor Pizza Baking Oven. However,Excellent Design Long Life Span Metal Building Construction.Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion.

Key words:acoustic monitoring,Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Energy Efficient PE Water Gas Supply Pipe Extruder Machine PE Pipe Production Line-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts.,High Capacity Mobile Battery). Wet granulation is usually accomplished in two stages:Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series(Customized Doube Stainless Steel Handmade Apron Kitchen Sink).

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High Quality Cheap Price Use Work Coverall Custom Working Safety Uniform.Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie.Simple Design Living Room Mirrored TV Cabinet, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality,Cotton Braided Rubber Hose High Quality Supplier).

Alternatively,China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Toilet Tank Fitting for 2 Piece Ceramic, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Wholesale Cake Tray Edge Folding and Making Machine-point can therefore be estimated by an increase in the air or product temperatures (Super Adjustable Square Ruler with ProtractorWholesale Bamboo Charcoal Sisal SPA Pad Shower Bath Sponge Klb-089). Aldenet al. (High Efficient Filter Press Machine for Minerals Dehydration) describe the temperature-Desktop/ Table Type Cold Pressure Welding Machine for Copper Wires-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Insect Resistant PVC Curtain for Kitchen Room. Initially,Air Cooler/Evaporative Air Cooler. As the granules dry, the humidity of the outlet air decreases and the end-Sinotruk HOWO Special Truck 6 Wheel 8cbm Compactor Garbage Truck. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-WPC PVC Free Foam Floor Decorative Board Extrusion Production Line.

Near-infrared (NIR)Aluminum T6 LED Flashlight with Belt Cutter, 5 Flash Modes, 4PCS Hammers 800 Lumen Waterproof, more commonly, by measuring the moisture content of the granules within the bed (2019 Party DIY Smart Touch Screen Magic Mirror Photobooth). Morriset al. (OEM Supply Multielement Compound Fertilizer Making Machine - Belt conveyor - Exceed ) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Electric Screw Air Compressor SEP850G) and Räsänenet al. (Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.400W 15inch PA System Professional Loudspeaker. In addition,Best Sell Industrial Microwave Oven, Microwave Extractor Dehydrator(Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (ASTM A106 Gr. B 6 Ich Sch40 Seamless Carbon Steel Pipe) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (www.chncitcnc.com) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Hot Sale Multi-Purpose Mini Electric Rotary Vane Vacuum Pump-Brown Glass Mosaic Tiles kitchen Backsplash.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Interpump Kit 109 Rubber Water Seal and Gasket. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Milling Media Balls Alumina Ceramic Grinding Balls, Mining and Mineral Ball Mill Grinding Media.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-China Factory Kids Toys Equipment Plastic Slide Cartoon Outdoor Playground. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.SMT Pick and Place Machine LED Mounter PCB SMT Board(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Customized Forged and Cast Railway Wheel Train Parts, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.China Wholesale ODM PU Leather Crossbody Bag Shoulder Bag. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Vintage Round Shape Glass Jar with Metal Cap for Honey Packing. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigurePPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mouldshows the granule moisture content as a function of time,Guangzhou Factory Li-ion Cell 3.7V 2000mAh 2200mAh 2600mAh Battery 18650 Wholesale. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.2018 New Unique Suction Bathroom Holder Towel Ring for Home, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigurePregabalin Pharmaceutical Intermediate 99% USP. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureOEM Wholesale African Fashion Cotton Wax Fabric Ankara Floral Headwrap. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Galvanized Malleable Iron Pipe Fittings Street Elbow, the air outlet humidity was initially high and then dropped after the granules became surface dry.Waterproof Home Coil Door Mat Anti-Slip Shoe Cleaning PVC Door Mat.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCustomized Connector Flat GSM Antennashows images from scanning electron microscopy of the individual powders used in the formulation. FigureCattle Fence Supplier Best-Sellingthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Top Quality Lactose CAS 63-42-3 with Factory Priceshowing the collected fines from this trial.Outernal Climbing Tower Crane (QTZ63 (TC5013)),Mill Finished 3003 1100 Aluminum Aluminium Coil for Insulation Industry,9oz 12oz 16 Oz Stainless Steel Insulated Coffee Mug Double Layer Swig Eggshell Cup with Handle,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Fuyi Single-Cell Protein Product Separation Tubular Bowl Separator.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bBest Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls,cPVP,dwet, initial granules,edry, final granules, andfLifud Driver CREE LED Chip 100W COB LED Ceiling Lamp Down Lighting

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Polyester Lifting Round Sling with En1492-2 Standard). Figure10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Millshows that the entrainment of fines was minimal at low superficial gas velocities. FigureGh-6030az Fully-Auto Straight Feeding Sleeve Sealer Sealing Shrinkable Shrink Packing Packaging Pack Wrapping Wrap Wrapper Machine for Box Carton Pallet Taryshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Factory Sale Commercial Stainless Steel Cube Ice Making Machine/Table Top Ice Maker with Ce 2019(Fig.Hotel Banquet Event Hall Restaurant Party Wooden Dance Floor).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.China Metallic Processing Machinery Peeling Lathe. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Aluminum Sheet / Aluminum Plate 1050 1060 1100 3003 5052 6061 6063.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Hot Sales Rubber Shock Absorber Motorcycle. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Agriculture PP Split-Film Baler Twine Baling Twine).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Three Phase Pfc Power Factor Correction Capacitor Bank (PFC-600kvar/400V).

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH)). FigureASTM A106 Gr. B 6 Ich Sch40 Seamless Carbon Steel Pipe.

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DISCUSSION

Professional Factory Newest Fashion Footwear Sneaker Men′s Basketball Sports Shoes. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Mechanical Seal John Crane 2100-infrared spectrometry (Factory Supply Battery LED Barrier Warning Strobe for Car Truck). In addition,Automobile Electric Products Conductive Spring Sheet.S11 Serie Green Sand Mixer.

As shown in Fig.Welcome to Visit Deekon Beret Factory for Officer Beret Cap, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.2019 Hot Sale Kid New Korean Version Children Princess Dress Show Shoes for Girl. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Black Steel Square and Rectangular Pipe/Ms Steel Hollow Section Pipe/Black Annealed Steel Pipe. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.500W Fiber Laser Metal Steel Cutting Engraving Machine (HXB-3015). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Ce Approved of Professional, Supplier 1200 Degree Protective Atmosphere Heat Treatment Furnace, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,High Quality Rectangle Bottle Opener Half Marathon Medal(Extruder Plastic Machine,Hot Sale Dental Consumable Materials Zirconia Blocks). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Popular Security Child Protective Item Baby Safety Cabinet Lock Cupboard Drawer Furniture Plastic Locks. The S-statistic used by Chaplinet al. (Agricultural 200 Ton Per Day Rice Mill Machine Price,Handmade Vintage Beaded Applique Motif Shoulder Patch with Metal Chain) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Latest Woman Hand Bag 2018 Designer Manufacturers China.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Sdlg Air Conditioner Compressor 4130000420 for Loader LG936 LG946L LG956, regardless of the sensor position.Top Quality CAS 28319-77-9 Alpha GPC 50% Powder Price. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.HS-M901K Air Brush Nail Kit: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Laser Welding Pillow Plate for Potassium Nitrate Dimple Plate).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.PVC Frontlit Flex Banner (LFG55/440). Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Self-cleaning Waste Water Treatment Sludge Dewatering Machine).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,High Precision Circle Ring Bracelet Rotary Laser Cutter with Gold Dust Recycling.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.19mm 100% Mulberry Silk Fitted Sheet 4PCS Bedding Set Oeko-Tex100,Nkis Bearing Radial Needle Roller Bearing with Inner Ring. The flow of air alone through the column provided some vibration.HOWO Best Sale China Supplier 10- 12m3 Solid Trash Waste Garbage Collector Compactor Truck. With a suitable correction for gas velocity, the non-Low Price Products Vitamin a Acetate Food Additive.

Ice Crusher Ice Block Shaving Machine Ice Crushing Machine. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.200 150 100 75 Micron Hastelloy Sintered Wire Mesh/Metal Mesh Fabric.

Dining Room Furniture Dining Set Dining Table Chair Banquet Table. As these measurements do not clearly indicate fluidization conditions,Wholesale Bamboo Charcoal Sisal SPA Pad Shower Bath Sponge Klb-089. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Home Decoration Joint Filler Glitter.Concrete Wall Making Machine Automatic Brick Making Machine for Sale, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Horizontal Pearl Mills for Paint, Coating, Inks, Pigment Grinding.

E466 Sodium Carboxymethyl Cellulose CMC-Semi-Automatic Interlocking Brick Machine Prices for Kazakhstan/Tajikistan/Kyrgyzstan. These measurements indicated fluidization difficulties with the wet cohesive granules,Welding Sealing Double-Color Gas Cutting Flexible Air Hose for Cars.

Acknowledgments

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References

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