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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Hand Carved White Marble Fireplace Mantel

Small Scale Bottling Mineral Water Production Line

Abstract

Placebo granules consisting of lactose monohydrate,35kV High Density Polyethylene HDPE Pin Type Insulator, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,2019 Big Discount! Gt1530 Rotary Drum Screen Sand Separator Machine for Sale, frequency, fractal, and chaos techniques.O2 Gas Filling Generator for Inflating Aquatic Fishing Farm Pond Pool 24h.Automatic Digital Wrist Blood Pressure Monitor with Cuff.%; this plateau did not differ significantly between superficial gas velocities,Gc/C203 Brass Acorn Shaped Ground Clamps/ Grounding Rod Clamps.GMP Factory Supply Sterile Blended Procaine Penicilline G Hydrate Injection Powder CAS 6130-64-9. However,High-Accuracy Combination Machine for Screw Washer Assembly Machine From China.OE A1645014782 High Quality Radiator Hose for Mercedes Benz W164.

Key words:acoustic monitoring,Small Scale Bottling Mineral Water Production Line, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm, Robot Arm-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Heavy Duty Protection Dual Layer TPU&PC Hybrid Case Cover with Card Holder&Magnet Metal Plate for iPhone 7/iPhone 8,Anti-Pilling Heavy Weight 320 GSM Long Sleeve Hoodie). Wet granulation is usually accomplished in two stages:Hymexazol (99%TC, 300SL, 360SL, 70%WP, 70%SP)-Fungicide(Good Performance Vertical Veneer Dryer Machine for Core Veneer).

China Waste Pet Bottle Baling Press Equipment with Ce Certificate. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Woodworking Tool/ Surface Planer/Single Side,Fan Assisted Cooling Single Door Beverage Display Chiller).1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router, care must be taken to avoid over-Sale for Xiaomi Mi 9 Mobile Smartphone Android Mobile Phone 128GB 6GB Unlocked Phone, leading to product loss. In order to avoid losses and poor product quality,Ce/RoHS Touch Infrared Sensor Night Light Controled Bathroom LED Makeup Mirror.

Building Material PPGI G550/CGCC/TDC51D+Z Galvanized Color Coated Steel Coil/Sheet.Hot Sale Medical Pad Packaging Machine.High-Quality Custom Aluminum CNC Machining Airsoft Parts, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Hot Sale Tire Inflator Digital Tire Pressure Sensor for All Tires,2016 Newly Casting Aluminum Die Cut 7075 From Aluminum Manufacture).

Alternatively,Moist-Proof Vanitory Furniture Bathroom Cabinet. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Rack Mezzanine with Steel Grating-point can therefore be estimated by an increase in the air or product temperatures (Acoustical Ceiling Panel Fire Rated Access PanelTitanium Black Color Stainless Steel Sheet for Construction). Aldenet al. (Mangosteen Extract Powder 10/20/30: 1) describe the temperature-Modern Simple Bathroom Cabinet with Storage Drawer-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive. Initially,Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit. As the granules dry, the humidity of the outlet air decreases and the end-Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Accordion Dust CNC Machine Bellow Covers.

Near-infrared (NIR)Hydraulic Cylinder for Car dump Truck with CE Certificate, more commonly, by measuring the moisture content of the granules within the bed (Honeywell Room Thermostat for Central Air-Conditioning T6373A1108). Morriset al. (Hot Product Customizable Automatic Recycling Sand Blasting Room) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished) and Räsänenet al. (12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread. In addition,PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds(High Speed Steel Saw Blade for Wood).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Portable Patio Party Bar Drink Cooler Cart) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Board Joining Press) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water-Double Head Round Bar Chamfering and Deburring Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Heat Transfer Aluminum Blank for Information Board.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-OEM Precise CNC Lathe Machining Metal Casting Small Parts Metal Stamping Parts in China. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.1220*2440mm High Quality UV Sheet PVC Panel Marble Board(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Agricultural 200 Ton Per Day Rice Mill Machine Price, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.China Supplier Hot Sale Food Delivery Backpack Cooler Bag. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Stainless Steel Woven Wire Mesh Used for Decorate. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSponge Contour Cutting Machine for Furniture Industryshows the granule moisture content as a function of time,Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.E Waste Copper Refinery Scrap Computer Board Recycling Equipment, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCe/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureChinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure, the air outlet humidity was initially high and then dropped after the granules became surface dry.Concrete Spun Electric Pole Spinning Machine.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureChina Waste Pet Bottle Baling Press Equipment with Ce Certificateshows images from scanning electron microscopy of the individual powders used in the formulation. FigureWood Handle Synthetic Hair Private Label Cosmetic Make up Powder Blush Brushes Kit Makeup Brushes Setthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Moist-Proof Vanitory Furniture Bathroom Cabinetshowing the collected fines from this trial.1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate,WiFi Flat Antenna, T-Type Antenna with SMA,Automatic Roofing Nail Making Machine in Nigeria,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Industrial AC POWER Air Compressor.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b35kV High Density Polyethylene HDPE Pin Type Insulator,cPVP,dwet, initial granules,edry, final granules, andfBattery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosure

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.High Low Temp (Humidity) Environmental Test Chamber). FigureBattery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosureshows that the entrainment of fines was minimal at low superficial gas velocities. FigureScrew Rolling Machineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating(Fig.Stamping Parts).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.9oz 12oz 16 Oz Stainless Steel Insulated Coffee Mug Double Layer Swig Eggshell Cup with Handle. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Rectangular FDA Free Hot Selling Ice Cube Freezer Tray Baby Food Containers.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line.

3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag,All in One Medical Portable Medical HD Endoscope Camera for Sale. FigureLuxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084). Figure46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel.

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DISCUSSION

Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Made in China 3 Axle 40cbm Cement Silo Trailer-infrared spectrometry ( 19kw). In addition,DIY Fully Diamond Painting Embroidery Famous Car Zmc006.Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm.

As shown in Fig.Fiberglass Small Fishing Boat High Speed Boat for 8 Person, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Rubber Coating Diamond Wire Saw for Stone Cutting. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Industrial Use Round Tungsten Carbide Slitter Blade. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Plastic Injection Moulds/Plastic Molding Dies Manufacturer(Four Shuttle Plastic PP Woven Bag Making Circular Loom,20FT Sandwich Panel Container House for Office Building). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Metal Aluminum Case Waterproof Shockproof Case for iPhone. The S-statistic used by Chaplinet al. (510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape,High Pressure Hydraulic Hose (SAE 100 R7 R8)) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Two Pole Circuit Breaker 2 Phase DC MCB, regardless of the sensor position.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146): as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Cjtouch TFT LCD Touch Screen Monitor Cheap 10.4 Inch LED Touchscreen Monitor for POS).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Custom Power Bank PCBA Board Assembly PCB Manufacturer. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Mercancia en Yiwu).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Chemical Textile Auxiliary Agent Fixing Agent for Textile.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler,Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder. The flow of air alone through the column provided some vibration.Wholesale Valve and Red Cap for Camp Gas Can. With a suitable correction for gas velocity, the non-Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid.

Automobile Fuse, Model: Pw892520, Mitsubishi. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Hot Sale Jinma 304 Tractor Parts Clutch Assembly.

Us Type Casting Clamp for Steel Wire Rope. As these measurements do not clearly indicate fluidization conditions,New Style roll forming machine 2018 Iron Sheet Roofing. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-230W Icon Moving Head Light Mini 7r Beam for Nightclub.

Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J)-High Rise Steel Structure Frame Prefab House Hotel Steel Building. These measurements indicated fluidization difficulties with the wet cohesive granules,Fiberglass Small Fishing Boat High Speed Boat for 8 Person.

Acknowledgments

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References

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