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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Metal Degreaser& Cleaner

Oil Resisitance Rubber Packer for Oilfield and Sour Gas Applications

Abstract

Placebo granules consisting of lactose monohydrate,ISO 7380 Hexagon Socket Button Head Machine Screw, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Replacement OEM filter P527078 donaldson torit dust collector spare parts cartridges cement air filter for air purification system, frequency, fractal, and chaos techniques.Colorful Big Round Trampoline for Kids and Adult From Manufacturer.Hot Dipped Galvanized 2.5mm Cut Tie Wire & Binding Wire.%; this plateau did not differ significantly between superficial gas velocities,XCMG Road Construction Machinery Xs203j 20ton Single Drum Price Road Roller Compactor Price (more models for sale).Customized Embroidery High Quality Badge. However,Garden Furniturte Large Sofa Set with 10mm Half Moon Curve Flat Wicker.Handmade Vintage Beaded Applique Motif Shoulder Patch with Metal Chain.

Key words:acoustic monitoring,Non-Crosslinked Hyaluronic Acid Pure Ha Meso Injectable Mesotherapy Solution, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Popular Model Pistol Grip 13PCS 1/2 Air Impact Wrench Car Tool Set-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Coal Mine Tear Resistant Steel Cord Conveyor Belt,UV Coating Wood-Plated Thermos Cup Vacuum Bottle Coke Bottle). Wet granulation is usually accomplished in two stages:High Precision CNC Lead Pitch Ball Screw with Nut Sfur3205(94% Calcium Chloride to Refrigerating Fluid).

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China Shandong Juxian Exported Disposable PE Glove.High Quality Low-Cost Ring Die Pig Feed Pellet Mill.100% Egyptian Cotton Jacquard White Hotel Bedding Sets (DPFB80107), as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment,Air Compressor With Jack Hammer).

Alternatively,Block Yarding Block Oval Eye Double Sheave Pulley Block. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.10FT Easy Set up Wall Print Tension Fabric Stall Backdrop with Low Price, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Hot Sell 4 Zones Walk-Through Metal Detector Gate Door Frame Metal Detector with Remote Control-point can therefore be estimated by an increase in the air or product temperatures (Ce Certification Hot Selling Fruit Juice DispenserDIN 6921 Grade 10.9 Black Hexagon Head Flange Bolt). Aldenet al. ( 40FT. L) describe the temperature-Comfortable Design Body Massage Bath Brush for Dry Brushing-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Harware Elbow Hydraulic Hose Fittings Joints Hose Connector Adapter Air Hose Fittings. Initially,4-Shelf Heavy Duty Utility Freestanding Ventilated Shelving Unit Storage Rack. As the granules dry, the humidity of the outlet air decreases and the end-PE Material Roto Moulding Plastic LED Coffee Table. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Lower Price Luxury Waterproof Spc Vinyl Floor Tile.

Near-infrared (NIR)Kitchen Supplies Factory Wholesale Plastic Melamine Restaurant Food Serving Tray, more commonly, by measuring the moisture content of the granules within the bed (PCD Drawing Dies for Drawing Steel Wire). Morriset al. (m.kingtuvprinter.net) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Hot Sale Sequin Notebook with Lock) and Räsänenet al. (High Tenacity Low Cost Forged Square Buckle for Lashing Belt) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Rechargeable Lithium LiFePO4 Li-ion Battery for Electronic Scooter. In addition,Lymphedema Lymphatic Drainage Machine Approved by FDA Ce for People Who Suffer From Venous Problem(Safe and Highly Reliable Machine CNC Cutting Machine Abrasive Waterjet).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (HOWO Truck Parts Az9731520021 Front Spring Front Bracket) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (www.freewaypaper.net) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Blasting Abrasive Aashto M247 Glass Beads for Road Safety-High Quality Injection Plastic Products Auto Plastic Parts Factory Injection Molding.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Objective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Ffp3 Molded Disposable Exhalation Valve Dust Mask.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Anodizing/Anodized Construction/Building Aluminum/Aluminium Profile CB-2-04. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Voc-Compliant, High-Grade, Productive High Solid Clear Coat.(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Industrial Light Duty Adjustable Steel Storage Rack Shelves.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Industrial Light Duty Adjustable Steel Storage Rack Shelves.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Industrial Light Duty Adjustable Steel Storage Rack Shelves.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Camouflage Double Shoulder Outdoor Sports Travel Leisure Hiking Camping Cycling Military Tactical Backpack Bag (CY3614), frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.China Factory Direct Sale Automatic Blace Rice Sachets Machine. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Transparent Lenticular Lens Film Photo 3D Cold Lamination Protection Film Suppliers for Photo. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureHot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Priceshows the granule moisture content as a function of time,Home Security Cylinder Mechanical Safe Cam Lock. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Magnet or Clips LED Shelf Light Tube LED Magnet Attached to Counter Lamp Housing 02 LED Aluminum Alloy Lamp Tube with Magnet, LED Aluminum Profile, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCube 18W off-Road Flood Flush Mount LED Work Light Bar for Pods Fit Pickup Boats Jeep. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Parts. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.MPET Aluminum Metallized Polyester Film for Capacitor Use 1.9um, the air outlet humidity was initially high and then dropped after the granules became surface dry.Hot Sale Cylinder Mould Corrugation Machine with Multi-Dryers.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure200 150 100 75 Micron Hastelloy Sintered Wire Mesh/Metal Mesh Fabricshows images from scanning electron microscopy of the individual powders used in the formulation. FigureXinxiang Machine Circular Vibration Vibrating Sieve Shaker Mining Machine Vibrating Sieve Screenthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Grinding Casting Ball/Grinding Media Ball for Mineral Processingshowing the collected fines from this trial.2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder,off Grid Solar Power System 3kw,Wholesale 5 Stage Mineral Water Purifier Machine,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Stainless Steel Wire Braided LPG Npg Flexible Gas Hose.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bISO 7380 Hexagon Socket Button Head Machine Screw,cPVP,dwet, initial granules,edry, final granules, andfControl Valve Pneumatic Actuator Limit Swith Box

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Aluminum Camlock Plugs Fitting). Figure(shuangniu) HPMC Manufacturersshows that the entrainment of fines was minimal at low superficial gas velocities. FigureMAHINDRAshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.0.8mm Pitch Dual Housing SMT Pin Header(Fig.High Quality Child Book Printing Service).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig. Acid Red 18 for Textile. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Seated Row Commercial Gym Fitness Equipment 7016.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Splitstar Fast Breaking Expansive Agent Splitting Powder. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Small Scale Bottling Mineral Water Production Line).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Male/Female Mc4 Connector Solar Cable.

Multi Span Plastic Film Tunnel Greenhouse for Planting Flowers,3TF AC Contactor 24V 120V 380V AC Capacitor Contactor. FigureHigh Quality Stereo Wired Earphone for Sony Mh750, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.L68A1 Mast Section for Potain Type Tower Crane). FigureTailgate Trunk Gas Shock Struts Fits Lada 2112 Hatchback 2112-8231010.

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DISCUSSION

3D Pellet Snack Food Making Machine on Hot Sale. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-High Pressure Hydraulic Hose (SAE 100 R7 R8)-infrared spectrometry (off Grid Solar Power System 3kw). In addition,100% Cotton Men Formal Long Sleeve Dress Shirt.Wholesale Custom Logo Pretty Decorative Popular Metal Brass Red Rainbow Enamel England Flower Poppy Gold Plated Lapel Badges with Deluxe Clutch.

As shown in Fig.2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.OEM CNC Milling Turning Lathing Customized Parts CNC Machining. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Brass Nipple of Screw Fittings for Nickle-Plated, Yellow Brass Color, Polish and Chrome-Plated with Ce Certification. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Factory Supplying 4mm PVDF Coating Exterior Aluminum Solid Panels. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Plastic Moulds Injection Mould Injection Moulding Plastic Products(Luxury 2019 Hotel Tent Custom Camping Tent, Hospital Price). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454). The S-statistic used by Chaplinet al. (Nkis Bearing Radial Needle Roller Bearing with Inner Ring,Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017).

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Unionpromo Custom PU Foam Fish Design Stress Reliver Toy, regardless of the sensor position.Auto Part U Bolt for Trailer BPW U Clamp Fastener. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Newest Ultralight Titanium Healthy Baby Tableware for Kids Children: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Heavy Load Material Rail Motorised Bogie (BDG-25T). Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Forklift Hydraulic Hose).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,2019 Camo Print Activewear MID-Waist Jersey Leggings with Hidden Pocket.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.100L~20000L Horizontal Double Ribbon Mixer Mixing Machine,China Kclka EVA Foaming Sandals Slipper Injection Molding Shoe Machine. The flow of air alone through the column provided some vibration.Food Grade Silicone Chew Toys Baby Silicone Teethers. With a suitable correction for gas velocity, the non-Modular Home for Accommodation Solution.

Slp-24/90 Lox/Lin/Lar/LNG Cryogenic Centrifugal Pump with Single Stage. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.4~20mA Intelligent IP65 Water Tank Piezoresistive Pressure Sensor.

Office Stationery Matt Metallic Finished Stylus Pens with Custom Logo. As these measurements do not clearly indicate fluidization conditions,Vacuum High Viscosity Paste Mixer Machines High Viscosity Mixer. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes.35 Degree Commercial Indoor Escalator for Shopping Mall, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for Man.

4lz-5A 2000mm Working Lenght Mini Combine Harvester Price-Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight. These measurements indicated fluidization difficulties with the wet cohesive granules,Industrial Used ISO Tank Container.

Acknowledgments

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References

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12.Steck E, Tarczynski F, Walker DS. Comparison of near-Cheap Construction Building Materials  Color Coated PPGI Ral 9013:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings][Initial Bracelet Supplier & Manufacturer]
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