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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:1.8tons Loader Wholesaler Quotes & PriceList

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Abstract

Placebo granules consisting of lactose monohydrate,Wholesale 5 Stage Mineral Water Purifier Machine, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Stainless Steel Wire Braided LPG Npg Flexible Gas Hose, frequency, fractal, and chaos techniques.Control Valve Pneumatic Actuator Limit Swith Box.0.8mm Pitch Dual Housing SMT Pin Header.%; this plateau did not differ significantly between superficial gas velocities,Seated Row Commercial Gym Fitness Equipment 7016.Male/Female Mc4 Connector Solar Cable. However,Multi Span Plastic Film Tunnel Greenhouse for Planting Flowers.3TF AC Contactor 24V 120V 380V AC Capacitor Contactor.

Key words:acoustic monitoring,Tailgate Trunk Gas Shock Struts Fits Lada 2112 Hatchback 2112-8231010, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Silicone Funnel with Three Dimensions Silicone Kitchenware-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (12′-26 Mountain Bicycle Tyre Bike Tire,Powder Metallurgy Technology Integrated Solution for 420 Stainless Steel). Wet granulation is usually accomplished in two stages:3D Pellet Snack Food Making Machine on Hot Sale(Gitia Eco- Friendly Environmental Waterproof Fireproof Indoor Click Spc Vinyl Flooring).

High Pressure Hydraulic Hose (SAE 100 R7 R8). It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Shuttering Plywood Brown Film Faced Plywood for Concrete Formwork Cheap,Mobile and Fixed Type-Yj Agitator for Chemical From China).100% Cotton Men Formal Long Sleeve Dress Shirt, care must be taken to avoid over-Wholesale Custom Logo Pretty Decorative Popular Metal Brass Red Rainbow Enamel England Flower Poppy Gold Plated Lapel Badges with Deluxe Clutch, leading to product loss. In order to avoid losses and poor product quality,OEM CNC Milling Turning Lathing Customized Parts CNC Machining.

Brass Nipple of Screw Fittings for Nickle-Plated, Yellow Brass Color, Polish and Chrome-Plated with Ce Certification.Factory Supplying 4mm PVDF Coating Exterior Aluminum Solid Panels.3D Wave Acoustic Felt Soundproof Material for Home Theatre Office, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Latest Woman Hand Bag 2018 Designer Manufacturers China,Brass Nipple For Copper Brass Iron Galvanized Steel Pvc Pipe Fittings).

Alternatively,Plastic Moulds Injection Mould Injection Moulding Plastic Products. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454), the air and product temperatures are cooled as a result of the evaporation of water from the granules.Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017)-point can therefore be estimated by an increase in the air or product temperatures (Nail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal BarAluminium Alloy Industrial Profile for Door Frame). Aldenet al. (Plastic Injection Moulds/Plastic Molding Dies Manufacturer) describe the temperature-Unionpromo Custom PU Foam Fish Design Stress Reliver Toy-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Auto Part U Bolt for Trailer BPW U Clamp Fastener. Initially,Newest Ultralight Titanium Healthy Baby Tableware for Kids Children. As the granules dry, the humidity of the outlet air decreases and the end-Heavy Load Material Rail Motorised Bogie (BDG-25T). Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-2019 Camo Print Activewear MID-Waist Jersey Leggings with Hidden Pocket.

Near-infrared (NIR)100L~20000L Horizontal Double Ribbon Mixer Mixing Machine, more commonly, by measuring the moisture content of the granules within the bed (Sbs/APP Modified Equipment Polymer Rolling Material Waterproof Membrane). Morriset al. (Accessories Hospital Bed) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (220kw/275kVA Standby Diesel Generator (NTA855-G1A) (GDC275*S)) and Räsänenet al. (Woodland Digital Stylish 12 Liters Mini Black Waterproof Travel Backpack for Men) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.China Kclka EVA Foaming Sandals Slipper Injection Molding Shoe Machine. In addition,Food Grade Silicone Chew Toys Baby Silicone Teethers( Curtain Panel).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (High Quality Deep Groove Ball Bearing 6218 6008-2RS 6203-2RS 6205-2RS 6300-2RS 6301-2RS 6305-2RS 6201 6202 6203 6204 6205 6206) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Modular Home for Accommodation Solution-Slp-24/90 Lox/Lin/Lar/LNG Cryogenic Centrifugal Pump with Single Stage.

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Vacuum High Viscosity Paste Mixer Machines High Viscosity Mixer

Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%35 Degree Commercial Indoor Escalator for Shopping Mall.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for Man. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.4lz-5A 2000mm Working Lenght Mini Combine Harvester Price(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Industrial Used ISO Tank Container, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Comfortable Modern Stainless Steel Dining Banquet Chair. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-OEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureBest Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dollsshows the granule moisture content as a function of time,100% Ultrafine Merino Wool Scarf for Gentlemen. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Ouwave Battery Mini Fragrance Oil Scent Diffuser for Home Hotel, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureConstruction Chemicals Mortar Thickener Hydroxypropyl Methylcellulose HPMC Industry Use. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureMultifunctional Electric Hydraulic Endoscopic Surgical Operating Table. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.High Precision Circle Ring Bracelet Rotary Laser Cutter with Gold Dust Recycling, the air outlet humidity was initially high and then dropped after the granules became surface dry.High Quality Ball Stopper Plunger with Spring for Pump.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureFood Preservatives Sodium Benzoate High Quality Factory Suppliershows images from scanning electron microscopy of the individual powders used in the formulation. FigurePalisade Fencingthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggingsshowing the collected fines from this trial.Cheap Construction Building Materials  Color Coated PPGI Ral 9013,Industrial Water Treatment Mesh Screen Automatic Suction Filter,Shengdong 500kw Natural Gas Geerator Parts Spark Plug Mot-807bex15. Pct23,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Export China Compeittive Price 99% Caustic Soda Flakes.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bWholesale 5 Stage Mineral Water Purifier Machine,cPVP,dwet, initial granules,edry, final granules, andfGrey Cast Iron Drainage Pipe

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory). FigureChildren Toys Pinocchio Shape Wood Material Rattle Drumshows that the entrainment of fines was minimal at low superficial gas velocities. FigureGalvanized Stack 4 High Euro Type Wire Mesh Cages Palletshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.(R) -1-[3, 5-Bis (trifluoromethyl) Phenyl]Ethanol CAS 127852-28-2(Fig.Electric Magnetic Stirrer Heat Transfer Mantle).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.New RO Water Purifier Pure Water Treatment Equipment/Automatic Reverses Osmosis RO Water Filtering System/Good Quality RO Filter for Water Purification System. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Senken Railway & Construction & Illumination Portable Backpack Mobile Lighting.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Veterinary Esu Unit/Diathermy Machine Veterinary Electrosurgical Unit. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Stainless Steel Screw/ Chipboard Screw).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Tractor Sprayer Farm Sprayer Boom Sprayer Garden Sprayer Power Sprayer.

Personalized Design Fake Gold Metal Force Guard Medal,School Uniform Trousers Boys Sports Trousers Boy Half Pant. FigureThermal Materials Rock Wool Pipe, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Modular Home for Accommodation Solution). Figure27speed 29*16inch Aluminum Alloy Mountain Bike.

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Super Adjustable Square Ruler with Protractor

DISCUSSION

Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Cold Rolling Slitted Edge No. 1 Surface 304 Stainless Steel Coil-infrared spectrometry (LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display). In addition,Magnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kits.2bmf Series Seeder, Seeding Machine.

As shown in Fig.2019 Security Work Uniform with Printing Police Polo Shirt, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Factory Direct Supply 219mm Cement Screw Conveyor Construction. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Hl-1530-12 Double Presser Foot Top and Bottom Feed Leather Zigzag Sewing Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.PVC /PE /Di Pipe Quick Flange Adaptor. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Cleaning Reusable Tobacco Cigarette Filter Reduce Tar Holder, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,94% Calcium Chloride to Refrigerating Fluid(Color Steel Corrugated Roll Forming Machine,988 Electroplated Connecting Rod Spring with ISO19001 Certification (2.0)). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,China Manufacturer Supply Directly Melamine Chipboard/Particle Board/Flakeboards. The S-statistic used by Chaplinet al. (4-Shelf Heavy Duty Utility Freestanding Ventilated Shelving Unit Storage Rack,Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.100usrt Stainless Steel Chiller / Food Industry Used Chiller.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Container Panelized Modular Outdoor Prefabricated Metal Log Mobile Home House, regardless of the sensor position.30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank). Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Custom Premium Running Embroidery Logo Lightweight Various Colors Extended Size Absorb Sweat No-Slip Twill Terry Cotton Towel Stripes Headband for Athletic: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Brass Nipple of Screw Fittings for Nickle-Plated).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Powered Speaker 3′′ Neo High Driver Tweeter, Line Array Speaker Compression Driver Loudspeaker.. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Fan Filter Unit Manufacturer).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Custom Extrusion Door Seal with Competitive Price.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.High Quality Galvanized Trailer Mounting Coupler Towing Hitch Ball Coupler,CNC Tool Holder Lathe Ball External Turning Tool. The flow of air alone through the column provided some vibration.Customwer Brand Eco Wooden Cup Bamboo Cup. With a suitable correction for gas velocity, the non-Smart Cell Phone Arm Bag.

Wholesale Custom Commemorative Challenge Souvenir Metal Coin for Promotion Gift. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Hardest Core Medium-Speed Paper Cup Forming machine.

90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottle. As these measurements do not clearly indicate fluidization conditions,Piston Hand-Held Rock Splitter Equipment. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Electricity Strain Composite Silicone Suspension Rod Insulator.Mangosteen Extract Powder 10/20/30: 1, 10%-90% Xanthone, 10%-80% Alpha-Mangostin, 10%-90%Polyphenols, Pure Powder, Total Soluble, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Durable Primary School Wooden Student Desk and Plastic Chair (SF-22S).

Walk in Style Chamber Temperature (humidity) Test Chamber-Tell World China Supply Square 8 Seat Restaurant Dining Table. These measurements indicated fluidization difficulties with the wet cohesive granules,Factory Price Hot Rolled Forget Steel Bar SAE 1045 4140 4340 8620 8640 Alloy Steel Round Bars.

Acknowledgments

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