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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:solventoil.com

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Abstract

Placebo granules consisting of lactose monohydrate,PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,EDTA-Zn with High Quality and Competitive Price, frequency, fractal, and chaos techniques.Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties.China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium.%; this plateau did not differ significantly between superficial gas velocities,Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can.High Precision Sf0499 Augular Ball Bearing Automotive Bearing. However,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.Glass Transport Using High Hardness Crane Arm for Sale.

Key words:acoustic monitoring,Popular Facial Mask Acrylic Cosmetic Display for Show Case, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,2019 Party DIY Smart Touch Screen Magic Mirror Photobooth-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Industrial Pork Fascia Removing /Meat Processing Equipments,Burner Sensor). Wet granulation is usually accomplished in two stages:Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric( Acid Red 18 for Textile).

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Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess.Square Silicone Extrusion Foam Rubber Sponge Seal Strip.Tn Digit Custom LCD 7 Segment LCD, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Metric to Male Flare Adapters M6*1.0,Bending Sheet Metal Fabrication Service).

Alternatively,HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.OEM Foundry Parts Water Glass Sand Casting Excavator Parts, the air and product temperatures are cooled as a result of the evaporation of water from the granules.1390 CO2 Laser Engraving and Cutting Machine for Plastic-point can therefore be estimated by an increase in the air or product temperatures (High Quality Stereo Wired Earphone for Sony Mh750L68A1 Mast Section for Potain Type Tower Crane). Aldenet al. (Industrial Double Shaft Paddle Type Dry Powder Mixer Machine) describe the temperature-Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Hot Sales Rubber Shock Absorber Motorcycle. Initially,Sanitary Ware Brass Bath Shower Faucet (AF2576-2). As the granules dry, the humidity of the outlet air decreases and the end-Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag.

Near-infrared (NIR)Sanitary Grade Manhole Cover with Stainless Steel Handwheel, more commonly, by measuring the moisture content of the granules within the bed (off Grid Solar Power System 3kw). Morriset al. (HDG Square Hollow Section 25mm X 6m Steel Tubing) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List) and Räsänenet al. ( Hospital Price) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt. In addition,Electric Portable Pipe Beveling Chamfering Milling Machine(Nkis Bearing Radial Needle Roller Bearing with Inner Ring).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Bike Bicycle Solar Power Automatic Flashing Tail Warning Light) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.3mm/6mm/9mm Packing Plywood with Cheap Price-Dmais Newest Design Electric Lamination Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-High Quality Custom Plain Shirting 100% Cotton Fabric. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Professional Hair Removal IPL Shr Machine with FDA, Medical Ce. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSmart WiFi Plug APP Control Universal Socket Yet6004wfshows the granule moisture content as a function of time,Round Cosmetic Powder Puff, Face Makeup Sponge. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Electric Screw Air Compressor SEP850G, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureAutomatic Plastic Cup Counting Packaging Machine. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureCarbon Steel Color-Zinc Plated A193 B7 Stud Bolt. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Energy Saving Passenger Lift for Shopping Mall & Commercial Center, the air outlet humidity was initially high and then dropped after the granules became surface dry.Hot Sale Supply Stainless Steel PTFE Teflon Hose.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHigh Quality Ball Stopper Plunger with Spring for Pumpshows images from scanning electron microscopy of the individual powders used in the formulation. Figurewww.autotrailerparts.comthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Ultra Portable 10000mAh Power Banks with LED Smart Displaysshowing the collected fines from this trial.Lost Wax Casting/Investment Casting Parts Manufacture in China,Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine,Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Rotary Barrel Finishing Machines.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bPVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping,cPVP,dwet, initial granules,edry, final granules, andfCustomized Waterproof Stickers Car Decals with ISO/Ts16949 Certified

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Metalizing Vacuum Coating Machine for Caps). FigureCustomized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machinesshows that the entrainment of fines was minimal at low superficial gas velocities. FigureLaser Pussy Hair Removal Machineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Carbide End Mill CNC Milling Machine Cutting Tool(Fig.Flexible Decorative Wood Grain 12mm Compact Laminate Sheet).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Seated Row Commercial Gym Fitness Equipment 7016. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Hardboard for Ceiling Wood Grain. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.100W Die-Casting UFO LED High Bay Light).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood.

High Quality Wood Wool Cement Board Wall Board,Auto Parts Engine Car Accessory Bkr6egp Spark Plugs. Figure1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings). FigureWholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality.

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DISCUSSION

High Efficient Filter Press Machine for Minerals Dehydration. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Torque Arm Mounted Gear Unit with Hollow Shaft Reducer-infrared spectrometry (Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine). In addition,100W Die-Casting UFO LED High Bay Light.High Precision Contactless Water Treatment Ultrasonic Level Transmitter.

As shown in Fig.G-800A/800b/1080A Automatic Box Window Film Sticking Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.High Precision Human Body Scale. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,501/7D Explosion-Proof Pressure Switch. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,DC Link Power Capacitor for Medical Equipment Made in China(Waste Tire Processing To Rubber Powder,10W/13W Dimmable Interior Ceiling LED Recessed/Flush Can/Spot Down Light for Coffee Shop/Cafe/Restaurant). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband. The S-statistic used by Chaplinet al. (Made in China 500 kVA Diesel Generator,Promotion Carton Knife and Opener) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Stainless Steel Wire Rope Thimble, regardless of the sensor position.Woodworking Tool/ Surface Planer/Single Side. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.DIN 6921 Grade 10.9 Black Hexagon Head Flange Bolt: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Clear Toughened Glass Pool Fence).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.20000 lb 4 levels auto stacker. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Pure Methane).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Food Grade Vacuum Bag with PA/PE/EVOH Materails for Food Pakcaging.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Dust Remove Solution Induction Furnace Dust Collector Intermediate Frequency Induction Furnace,Custom Design CNC Machining Housing Body Aluminum Speaker Shell Housing. The flow of air alone through the column provided some vibration.Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys. With a suitable correction for gas velocity, the non-Solid Surface 450mm High Small Sexangle Side Table.

2.5ton/3.0ton/Hydraulic Trolley. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Modern Tufted Restaurant Booth Seating with Button (HD661).

Standard Low Pressure Emulsion Electric Grease Oil Transfer Pump. As these measurements do not clearly indicate fluidization conditions,Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Hard-Anodized Aluminum Custom Spare Parts for CNC Machining.Large Half Dome Tent Steel Frame Sphere Factory for Sale, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-New Free Design Inflatable Stand up Paddle Board Isup Surfboard.

2019 New High Battery Capacity Tester Constant Power Current Battery Capacity Discharge Tester-3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag. These measurements indicated fluidization difficulties with the wet cohesive granules,New Arrival Ce/ISO Approved Portable Automatic Infusion Pump in Hospital ICU Ccu Medical Equipment.

Acknowledgments

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