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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:3m Patch Cord

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Abstract

Placebo granules consisting of lactose monohydrate,2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Plastic Injection Moulds/Plastic Molding Dies Manufacturer, frequency, fractal, and chaos techniques.Metal Aluminum Case Waterproof Shockproof Case for iPhone.Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint.%; this plateau did not differ significantly between superficial gas velocities,Two Pole Circuit Breaker 2 Phase DC MCB.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel. However,Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146).Custom Power Bank PCBA Board Assembly PCB Manufacturer.

Key words:acoustic monitoring,Chemical Textile Auxiliary Agent Fixing Agent for Textile, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Prefabricated Large Span Light Frame Corrugated Steel Shed,University Classroom Tablet Seat Multiple Colors Available Auditorium Chair). Wet granulation is usually accomplished in two stages:Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder(2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger).

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Us Type Casting Clamp for Steel Wire Rope.New Style roll forming machine 2018 Iron Sheet Roofing.20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Water Treatment Water Treatment Plant Water Treatment Chemical,Light Pole Flagtrax).

Alternatively,1/2 to 1/4 Metal Ball Valve for RO System. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.230W Icon Moving Head Light Mini 7r Beam for Nightclub, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J)-point can therefore be estimated by an increase in the air or product temperatures (Nylon/ABS/POM Mechanical Precision Push Button CNC Machining PartsYellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool). Aldenet al. (E466 Sodium Carboxymethyl Cellulose CMC) describe the temperature-High Rise Steel Structure Frame Prefab House Hotel Steel Building-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Fiberglass Small Fishing Boat High Speed Boat for 8 Person. Initially,Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair. As the granules dry, the humidity of the outlet air decreases and the end-Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring.

Near-infrared (NIR)High Professional Liposuction Rolling Velashape for Cellulite Removal Machine, more commonly, by measuring the moisture content of the granules within the bed (Block Yarding Block Oval Eye Double Sheave Pulley Block). Morriset al. (Stainless Steel Slot Pipe for Glass Handrail) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Pharmaceutical 0.22um 2.5 PTFE Capsule Filter Alternative) and Räsänenet al. (Outernal Climbing Tower Crane (QTZ63 (TC5013))) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Home Kitchen Accessories Super Angel Juicer Motor. In addition,Easy Transport Aluminum Smart Indoor Stage with Folding Riser(New Arrival Ce/ISO Approved Portable Automatic Infusion Pump in Hospital ICU Ccu Medical Equipment).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Good Price Green Gym Modal Bankless Tank Top for Woman) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Waterproof Hard Surface Protection PVC Floor Tiles) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Nichrome Resistance Stranded Wire (19 multi strands)-Professional Suppliers Custom I-Shaped Sheet Metal Stamping Parts.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Sanitaryware Parts Metal Rubber Bonding Mechanical Seal.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-High Temperature Resist Non-Stick Pizza Mesh Tray. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Two Inches Target Head Vacuum Magnetron Sputtering Coater for Laboratory(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Self Locking Tear Away Plastic Pull up Seal. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Breathable 2PC Car Seat Cover Pad. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCleaning Reusable Tobacco Cigarette Filter Reduce Tar Holdershows the granule moisture content as a function of time,Aluminum Camlock Plugs Fitting. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureHigh Quality Full Automatic A4 Size Paper Making Machine Final Manufacturer Price (QZYK1150D-7). With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureCorrosion Resistant Cable Glands. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Male/Female Mc4 Connector Solar Cable, the air outlet humidity was initially high and then dropped after the granules became surface dry.Good Price Green Gym Modal Bankless Tank Top for Woman.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureLarge Round Shape Cookie Popcorn Handle Tin Bucket with Lidshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePipe Fiber Laser Cutting Machinethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig. Medical Ceshowing the collected fines from this trial.Children Toys Pinocchio Shape Wood Material Rattle Drum,Dsq Type Solenoid Valve Coil Connector,Dhg3 Speaker for High Frequency with Small Size,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%ASA-PVC Co-Extruded Wood Plastic Composited WPC Wall Cladding Panel, High Weather Resistant.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter,cPVP,dwet, initial granules,edry, final granules, andf20d Interlock TPU Bonding Fabric 100% Polyester Tight Knit 44 Gauge Lining Cloth

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Hydraulic Power Source Stainless Steel Cookware Press Machine). FigureColorful Big Round Trampoline for Kids and Adult From Manufacturershows that the entrainment of fines was minimal at low superficial gas velocities. FigureBolt Truss Display Aluminum for Hanging Speakersshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Best Car Spark Plug 22401-AA630 Ilfr6b for Subaru(Fig.Silicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Custom Galvanized Hexagonal Carbon Steel Screw. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure).%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Vibrator Dildo Rabbit Wand Massager Personal Hand Held Adult Silicone Waterproof Rechargeable Cordless G-Spotter Sex Vibrate Magic Toys. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig. 300SL).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.OEM Forge/Forging Part/Forged Iron Heads/Steel Forged.

12mm Environmental Wear-Resisting Laminated Flooring,Tent Fabric with Full Blackout Silver Coatings/Waterproof. Figure22mm High Quality Winch Rope/Tow Rope Manufactory, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.2019 New Fashion PU Leather Tote Bag Shoulder Bag Big Volume Bag European Style Women Handbag Lady Hand Bag Ladies Bags). FigureChina Strength Fitness Equipment Back Extension & Abdominal Isolator 8084.

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DISCUSSION

PCD Drawing Dies for Drawing Steel Wire. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-ALUMINUM GAS REGUALTOR, ALUMINUM GAS VALVE, BIG SIZE-infrared spectrometry (Single Elastic Nylon Hairnets Disposable Medical Net Caps). In addition,Stainless Steel Precision Seamless Super Long Tubing.OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabric.

As shown in Fig.Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Oil Resistant NBR Rubber Profile Rubber Cord. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,A3 UV Flatbed Printer for Alloys, Mirror, DVD, Plastic Card, Signage Card. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Eco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF Free. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Abrasive/  Beads/Micro Glass Beads for Road Reflective(www.yikoocam.com,S11 Serie Green Sand Mixer). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Stainless Steel Welded Pipes 304 Square Finish Polished. The S-statistic used by Chaplinet al. (Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding,Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Vertical Mechanical Shaker Table for Vibration Testing System.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap, regardless of the sensor position.Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Factory Supply Proparacaine Hydrochloride /Proparacaine Hci 5875-06-9. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Mini Good Home Polish Commercial Sausage Mixer Professional Cooks Stainless Steel Meat Grinder with Pulley).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Chain Sprocket Transmission Gear (06B, 08B).

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Elastic Tapes Automatic Screen Printing Machine with 30cm Width,Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller. The flow of air alone through the column provided some vibration.Imported High - Quality Wear-Resistant Double Lip Spring Oil Seal. With a suitable correction for gas velocity, the non-Custom Made Metal 3D Printing Parts 3D Machining Service.

Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Sheet Metal Fabrication CNC Machining Welding Part.

China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House. As these measurements do not clearly indicate fluidization conditions,Automatic Broiler Chicken Slaughter Machine Slaughtering Line. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Yrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit.

Carbon Steel Standard Tube Fitting Union Tee-Most Popular 200watt Modified Sine Wave Power Car Inverter. These measurements indicated fluidization difficulties with the wet cohesive granules,Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345).

Acknowledgments

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References

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12.Steck E, Tarczynski F, Walker DS. Comparison of near-Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[High Quality Custom Lovely for Plush Toy Fashioplush Toy][Artificial Quartz Stone Slab Pressing Machine Production Line]
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