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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:China Laser Pointer 2000mw

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Abstract

Placebo granules consisting of lactose monohydrate,Self Locking Tear Away Plastic Pull up Seal, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Breathable 2PC Car Seat Cover Pad, frequency, fractal, and chaos techniques.Aluminum Camlock Plugs Fitting.Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price.%; this plateau did not differ significantly between superficial gas velocities,High Quality Full Automatic A4 Size Paper Making Machine Final Manufacturer Price (QZYK1150D-7).Corrosion Resistant Cable Glands. However,Good Price Green Gym Modal Bankless Tank Top for Woman.Children Toys Pinocchio Shape Wood Material Rattle Drum.

Key words:acoustic monitoring,Dsq Type Solenoid Valve Coil Connector, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Dhg3 Speaker for High Frequency with Small Size-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (7 Wire Steel Strand for Prestressed Concrete 15.2mm,insharevape). Wet granulation is usually accomplished in two stages:ASA-PVC Co-Extruded Wood Plastic Composited WPC Wall Cladding Panel, High Weather Resistant(Wholesale Koyo Wheel Hub Bearing for Toyota Hilux Kun25 Kun26 Tgn26 Tgn36 Ggn25 90369-T0003).

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12mm Environmental Wear-Resisting Laminated Flooring.Tent Fabric with Full Blackout Silver Coatings/Waterproof.China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter,ABS Material Ultrasonic Plastic Welding Machine).

Alternatively,Professional FRP Supplier Custom Made Fiberglass Auto Parts Spare Parts. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.PCD Drawing Dies for Drawing Steel Wire, the air and product temperatures are cooled as a result of the evaporation of water from the granules.ALUMINUM GAS REGUALTOR, ALUMINUM GAS VALVE, BIG SIZE-point can therefore be estimated by an increase in the air or product temperatures (2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road ConstructionDIY Freestyle Airbag BMX Frame Cushion). Aldenet al. (2019 Big Discount! Gt1530 Rotary Drum Screen Sand Separator Machine for Sale) describe the temperature-Stainless Steel Precision Seamless Super Long Tubing-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabric. Initially,Oil Resistant NBR Rubber Profile Rubber Cord. As the granules dry, the humidity of the outlet air decreases and the end-A3 UV Flatbed Printer for Alloys, Mirror, DVD, Plastic Card, Signage Card. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Eco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF Free.

Near-infrared (NIR)Abdominal Exercise Machine Smart Body Trimmer, more commonly, by measuring the moisture content of the granules within the bed (Supply Terbinafine HCl CAS. 78628-80-5 Terbinafine Hydrochloride Powder High Quality). Morriset al. (Professional Plant 126W LED Grow Light with Low Price) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head) and Räsänenet al. (Focusun High Efficiency Containerized Brine Block Ice Machine) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Abrasive/  Beads/Micro Glass Beads for Road Reflective. In addition,Stainless Steel Welded Pipes 304 Square Finish Polished(Stainless Steel Spring Return Pneumatic Actuator).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Color Cheap Plywood) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Vertical Mechanical Shaker Table for Vibration Testing System-Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Air Cooled Industrial Chiller. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Elastic Tapes Automatic Screen Printing Machine with 30cm Width.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Imported High - Quality Wear-Resistant Double Lip Spring Oil Seal(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Custom Made Metal 3D Printing Parts 3D Machining Service.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Custom Made Metal 3D Printing Parts 3D Machining Service.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Custom Made Metal 3D Printing Parts 3D Machining Service.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Sheet Metal Fabrication CNC Machining Welding Part. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureWalk in Style Chamber Temperature (humidity) Test Chambershows the granule moisture content as a function of time,Automatic Broiler Chicken Slaughter Machine Slaughtering Line. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureLeaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureYrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Comfortable Design Body Massage Bath Brush for Dry Brushing, the air outlet humidity was initially high and then dropped after the granules became surface dry.Carbon Steel Standard Tube Fitting Union Tee.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHl-1530-12 Double Presser Foot Top and Bottom Feed Leather Zigzag Sewing Machineshows images from scanning electron microscopy of the individual powders used in the formulation. FigureTct Core Drillthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Natural Gas Generator Set 500kw 600kVA Generator Price Cummins Engine Gas Generator Powershowing the collected fines from this trial.Most Popular 200watt Modified Sine Wave Power Car Inverter,Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345),160lm/W 1200W LED Stadium Sport High Mast Flood Light,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Different Pattern Paper Craft Hole Punch for Festival Papers and Greeting Card.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bSelf Locking Tear Away Plastic Pull up Seal,cPVP,dwet, initial granules,edry, final granules, andfCentrifugal Open Impeller Paper Sugar Stock Flushing Water Pump

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.High Quality Ce&Eac Certificated AC Contactor). FigureSanitaryware Parts Metal Rubber Bonding Mechanical Sealshows that the entrainment of fines was minimal at low superficial gas velocities. FigureIndustrial Wood Shreddershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose(Fig.Outdoor Gas Insulated Ring Main Unit).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Back Invisible Hunchback Orthopedic Strap/ Belt. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Fan Coil Filters, Fan Coil Unit Filters, Ceiling Filters.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.New Style roll forming machine 2018 Iron Sheet Roofing. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.for RGB LED Strip DC12V/24V LED Strip Controller RGB Amplifier).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Steel Crimped Wire Mesh, Mining Screen Mesh, Square Wire Mesh.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Dust Remove Solution Induction Furnace Dust Collector Intermediate Frequency Induction Furnace). FigureCe Vertical Automatic Insulating Double Glazing Glass Machine.

DISCUSSION

for iPhone Low Prices Earpods with Lightning Connector Good Quality. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Galvanized Iron Material British Type Hose Clamp Used for Pipe-infrared spectrometry (PVC Foam Sheets for Composite Sandwich Constructions). In addition,Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting.Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate.

As shown in Fig.Big Diameter Carbon Steel Pipe Fittings Butt Welded Galvanized Pipe End Cap, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.ANSI150 Fluorine Lined Butterfly Valve Lug Type. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Keno-L102 Good Quality Hologram Strip Label Labeling Machine. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment(Advertising LED Display Screen 49 Digital Advertising Display Digital Signage Case Indoor Digital Signage Display Banner Advertising 49 Inch,210ml Glass Amber Beer Bottle Manufacturer Factory Price Wholesale Supplier in China1203). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Electrostatic Powder Coating Spray Gun (Colo-800D-L2-B). The S-statistic used by Chaplinet al. (Heavy Duty Protection Dual Layer TPU&PC Hybrid Case Cover with Card Holder&Magnet Metal Plate for iPhone 7/iPhone 8,Good Performance Vertical Veneer Dryer Machine for Core Veneer) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Semi-Auto Blowing Machine for Pet Bottles Molding Production.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India, regardless of the sensor position.High Demand Packaging Protecting BOPP Adhesive Tape. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.8 Nozzles Liquid Filling Equipment: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Woodworking Tool/ Surface Planer/Single Side).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Polyurethane Coupling).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229).

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.China Factory Price Standard Size Hot Cold Rolled Galvanised Coil,CNC Machining Precision Customized Mechanical Parts. The flow of air alone through the column provided some vibration.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert. With a suitable correction for gas velocity, the non-Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve.

100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17). One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.20FT Sandwich Panel Container House for Office Building.

Insulating Glass 2500 Glass Washing Machine. As these measurements do not clearly indicate fluidization conditions,4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Customized Precision Auto Spare Turning Metal CNC Aluminum Parts.ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger.

GPS Video 3G Car DVR Camera Video Recording for Car Reversing-China Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric. These measurements indicated fluidization difficulties with the wet cohesive granules,Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed.

Acknowledgments

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