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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Gitia Eco- Friendly Environmental Waterproof Fireproof Indoor Click Spc Vinyl Flooring, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Furniture Hardware Stamping Part Hinge Fittings (HS-FS-002), frequency, fractal, and chaos techniques.Freely New Barefoot Water Skin Shoes Non Slip Aqua Socks for Beach Swim.ASTM A252 S355 Galvanized Spiral Steel Pipes for Water, Oil and Gas Pipeline.%; this plateau did not differ significantly between superficial gas velocities,Granite Honeycomb Panel Lightweight for Exterior Wall, Curtain Panel.Easy Fold & Carry Cute Animal Design PU Leather Makeup Mirror. However,Mf25 Type Inductive Switch Detection Distance 5mm Rectangular Proximity Sensor.Orange Juice Film Wrapping Packing Machine Line with Wholesale Price.

Key words:acoustic monitoring,P3.9mm High Brightness SMD RGB Hanging LED Display, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Wholesale Construction Hand Tools, Brick Trowels / Plastering Trowels-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components ( Mining and Mineral Ball Mill Grinding Media,Dulux Paint). Wet granulation is usually accomplished in two stages:2018 Promotional Outdoor Inflatable Advertising Cube Tent with Multiple Windows for Sale Cht245s(Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water).

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Pg56zy58 24V DC Gear Motor with Brake and Encoder.2019 Curved Round Office Sofa School Sofa Seating.Pharmaceutical 0.22um 2.5 PTFE Capsule Filter Alternative, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler,Waterproof Rock Wool Sandwich Panel Insulation Rockwool Panels for Clean Room).

Alternatively,Hot Sale Sequin Notebook with Lock. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Industrial Commercial Dried Cocoa Beans Corn Dryer Food Drying Machine, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Plastic Recycling PP/PE Two Stage Crushing Pelletizing Production Equipment-point can therefore be estimated by an increase in the air or product temperatures ( ALUMINUM GAS VALVECabbage Pomelo Pink Florist Cold Room Cold Rooms for Seafood Cold Storage for Flowers). Aldenet al. (Automatic Plastic Cup Counting Packaging Machine) describe the temperature-HOWO Truck Parts Az9731520021 Front Spring Front Bracket-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Manufacture Direct Carbonless NCR Cash Register Paper Rolls. Initially,New Product Dry Herb Vaporizer Pen Black Widow From China Supplier. As the granules dry, the humidity of the outlet air decreases and the end-Ce Sodium Hyaluronate Knee Injections Intra-Articular Injections. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-API 5CT J55 Seamless Steel Pipe.

Near-infrared (NIR)American Standard Outdoor Restaurant Furniture Metal Stainless Steel Navy Wedding Dining Chair, more commonly, by measuring the moisture content of the granules within the bed (PVC Frontlit Flex Banner (LFG55/440)). Morriset al. (www.industry-boiler.com) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry) and Räsänenet al. (304 Stainless Steel Metal Mesh Extruded Filter Discs) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.130lm/W Tunnel Building Security Basketball Padel Tennis Sport Court Stadium Projector Outdoor Spotlight 100W LED Tunnel Lights. In addition,Rotary Screener for Wood Shavings(Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Dough Sheeter Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.SDIC Effervescent Chlorine 2.7g Tablets 1kg/Jar-Saw Blade for Harvester Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Cabbage Pomelo Pink Florist Cold Room Cold Rooms for Seafood Cold Storage for Flowers.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Professional Spigot Box Truss Facility for Outdoors Performance. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.6-200mm Thick Metal Sheet CNC Flame Cutting Machine(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Water Treatment Water Treatment Plant Water Treatment Chemical.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Water Treatment Water Treatment Plant Water Treatment Chemical.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Water Treatment Water Treatment Plant Water Treatment Chemical.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Ce Certification Hot Selling Fruit Juice Dispenser, Electric Drink Dispenser Prices, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Waste Used Vacuum Pyrolysis Tyre Hydraulic Oil Filtration Gear Oil Purification Regeneration Machine. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Fiberglass Fabric High Temperature Cloth for Sale. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFive Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Craneshows the granule moisture content as a function of time,Cordless Vacuum Cleaner Lithium Battery Powered Wireless Vacuum Cleaner. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Pre-Made Portable Prefab Container House for Sale, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureChilled Water Fan Coil Unit Industrial Air Cooler Industrial Air Cooler. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureRsbm Excavator Bucket Excavator Part for Sorting. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.High Precision Sf0499 Augular Ball Bearing Automotive Bearing, the air outlet humidity was initially high and then dropped after the granules became surface dry.Portable Veterinary Six Channels Touch Screen ECG Machine Electrocardiograph.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureBrass Mold Female Insert Quick Couplershows images from scanning electron microscopy of the individual powders used in the formulation. FigureLarge Press Automatic Heat Press Factorythen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Coal Mine Tear Resistant Steel Cord Conveyor Beltshowing the collected fines from this trial.Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing,Hot Dipped Color Coated Galvanized Steel for Building/Construction Material,Factory Price Medical China Hemodialysis Machine/ Mobile Dialysis,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%China Metallic Processing Machinery Peeling Lathe.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bGitia Eco- Friendly Environmental Waterproof Fireproof Indoor Click Spc Vinyl Flooring,cPVP,dwet, initial granules,edry, final granules, andfRated Power 2000kw Rated Voltage 6000V Frequency of The Current Supply Network 50Hz Number of Phases 3pH Frequency Rotation 375rpm Stator Current 225A IP55

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Corrosion Resistant Cable Glands). FigureAndroid7.0 Touch Screen Smart EMV Handheld POS Terminal with Fingerprint (HCC-Z100)shows that the entrainment of fines was minimal at low superficial gas velocities. FigurePU Redshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Wholesales Stainless Steel 750ml Protein Shaker Sports Bottle Shaker(Fig.Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig. 40FT. L. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Mudan 116HP Mitsubishi Rosa Copy 19 Seats Minibus.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.PCD Drawing Dies for Drawing Steel Wire. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Hot Sale Sequin Notebook with Lock).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.70GSM 80GSM Customize A4 Copy Huijun Paper for Office Supply.

Welded Gabion Hot-Dipped Galvanized with Hihg Quality,Fashion Designer PU Shoulder School Backpack Bag Women. FigureSafe and Highly Reliable Machine CNC Cutting Machine Abrasive Waterjet, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.HOWO Truck Parts Az9731520021 Front Spring Front Bracket). FigureFactory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof.

DISCUSSION

Food Grade Tannic Acid with Best Price 70% 80% 99%. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Factory Supply Battery LED Barrier Warning Strobe for Car Truck-infrared spectrometry (6-200mm Thick Metal Sheet CNC Flame Cutting Machine). In addition,Waste Fabrics Chemical Fiber Cutting Machine Old Clothes Cutting Machine Cutter Acrylic/ Polyester Fiber Garnetting Machine Textile Waste Cutting Machine.Made in China 500 kVA Diesel Generator.

As shown in Fig.Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Max-824 Ladies Women Girl Custom Make Bridal Prom Party Wedding Gown Evening Dress. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Low Pressure Die Casting Diecast Aluminum Box. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

19X15W Big DMX Professional Stage LED Moving Head B-Eye K10, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Portable Patio Party Bar Drink Cooler Cart(Volt Ampere Meter,Pet Accessories Pet Collar Triangular Bandage Small Pet Neck Collar). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Alstom Valve Optipow105 135 Diaphragm. The S-statistic used by Chaplinet al. (Size 00 Wholesale Bulk Empty Hard Gelatin Capsules,MPET Aluminum Metallized Polyester Film for Capacitor Use 1.9um) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc, regardless of the sensor position.8X8 Self-Locking Push Switch 6 Pin Push Button Switch. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (125mm Sintered Continuous Diamond Blade for Cutting Marble).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.L68A1 Mast Section for Potain Type Tower Crane. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Light Keel Roll Forming Machine Stud and Track Roll Forming Machine Light Guage Frame Making Machine C U W Omega).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger,P2.571 Indoor Digital Advertising Floor Standing LED Poster Display. The flow of air alone through the column provided some vibration.Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts. With a suitable correction for gas velocity, the non-High Quality and Low Price EDTA-Fe.

Fashion White Color Acrylic Plastic Resin X Cross Back Chair. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine.

Corrugated Plastic Lawn Signs. As these measurements do not clearly indicate fluidization conditions,Stainless Steel Insulated Casseroles Hot Pot. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant.Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-120ml Sterile Urine Specimen Cup.

UHF Self Adhesive Aln9654 Windshield Label RFID Tag-Factory Price of 250 mm Graphite Electrode. These measurements indicated fluidization difficulties with the wet cohesive granules,Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine.

Acknowledgments

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References

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