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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Small Dogs Adult Dog Food Pet Food

Electricity Strain Composite Silicone Suspension Rod Insulator

Abstract

Placebo granules consisting of lactose monohydrate,Fast Dry Paper for Digital Printing, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light, frequency, fractal, and chaos techniques.Foska Office Use Hot Sale Heavy Duty Stapler.Automated Fue Extraction Devices.%; this plateau did not differ significantly between superficial gas velocities,PVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer.Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery. However,3.0mm PP Raschel Trailer Net.Gold Color Stainless Steel Mirror Sheet Made in China with Low Price.

Key words:acoustic monitoring,Rifle Swing Hydraulic Cylinder, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Agricultural Film Plastic UV Film Greenhouse Agriculture-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Portable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine,Chain For Tow Strap). Wet granulation is usually accomplished in two stages:High Precision Stick Film Patching Machine(Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm).

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Lifting Lights DMX Winch RGB Color LED Kinetic Tube.Health Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet.The Plywood Machine Automatic Spindle Veneer Peeling Machine Line, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Hot! ! ! Aerial Work Platform Truck Mounted Boom Lift,Double Hv Dead End Clamp Bracket).

Alternatively,Brass Water Spray Nozzle Water Garden Hose Nozzle Brass Nozzle. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Ultra Portable 10000mAh Power Banks with LED Smart Displays, the air and product temperatures are cooled as a result of the evaporation of water from the granules.42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard-point can therefore be estimated by an increase in the air or product temperatures (Glass Transport Using High Hardness Crane Arm for SaleDIN916 Hexagonal Screw to Stopw with Yellow Black). Aldenet al. (EVA Slipper Injection Moulding Machine) describe the temperature-1000W 1500W High Precision Fiber Laser Cutting Machine Sheet Metal for Aluminium Stainless Steel Plates and Tubes-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Professional FKM Eco Rubber 5/16 Inch Gasoline Hose. Initially,Machining,Auto Parts,Farming Parts,Metallic Bracket,Fabrication,Welding Parts,Metal Parts,Architectural Parts,Hardware,Clamps,Steel Cover,Stamping Parts. As the granules dry, the humidity of the outlet air decreases and the end-Issc Bluetooth Module for Bluetooth Headset Wireless Headphone. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-2019 New Arivals Christmas Gift.

Near-infrared (NIR)Abrasion Resistant Corrugated Rubber Conveyor Belt for Coal, more commonly, by measuring the moisture content of the granules within the bed (P3.9mm High Brightness SMD RGB Hanging LED Display). Morriset al. (PVC Data Strip for Supermarket Shelf Price Talker) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum) and Räsänenet al. ( Bridal Necklace Earring Jewelry Set) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.ANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zipper. In addition,201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished(O2 Gas Filling Generator for Inflating Aquatic Fishing Farm Pond Pool 24h).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (1215k 1215krr 130mm Suppliers/Manufacturers for Sale) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Modern White Fabric Living Room Secetion Sofa for Hotel Reception-Good Performance Vertical Veneer Dryer Machine for Core Veneer.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Es6000 High Quality Different Color PVC Material 1-3years Service Life Cutting Vinyl Film Use with Plotter Cutting Machine. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Power Supply Marine Series Diesel Generators 130kw. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Dehydrated Garlic Powder in Bulk at Wholesale Price(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,High Power 162W CREE LED 4X4 DRL Offroad Work Lights.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,High Power 162W CREE LED 4X4 DRL Offroad Work Lights.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,High Power 162W CREE LED 4X4 DRL Offroad Work Lights.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5), frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Customized Precision Aluminum Spare Parts CNC Machining Parts. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Grinding Casting Ball/Grinding Media Ball for Mineral Processing. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureStainless Steel Insulated Casseroles Hot Potshows the granule moisture content as a function of time,LED Light 3D Custom Acrylic Car Sign. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Disposible Adjustable Adult Child Medial Oxygen Venturi Mask, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigurePetroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureVertical Liquid Reciever for Refrigeration Units (ZRLC-644). The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Horizontal Storage FRP Tank Used for Above Ground and Underground, the air outlet humidity was initially high and then dropped after the granules became surface dry.Automatic Fast Speed Laminating Machine.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureOutdoor Customize Oxford Travel Sports Skateboard Bag Backpackshows images from scanning electron microscopy of the individual powders used in the formulation. FigureBoy Clothing Denim Down Jacket Suppliers for Salethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Stainless Steel Heating Mixing System Emulsifying Tank for Pharmaceutical/Creamshowing the collected fines from this trial.PVC White BS Thread Pipe Water Supply Piping System 5.6 Metres,LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W),AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFast Dry Paper for Digital Printing,cPVP,dwet, initial granules,edry, final granules, andfBest Price Concrete Pigments Iron Oixde Red, Yellow, Green

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Custom Power Bank PCBA Board Assembly PCB Manufacturer). FigureMade in China 3 Axle 40cbm Cement Silo Trailershows that the entrainment of fines was minimal at low superficial gas velocities. FigureNew Arrival School Supplies Hot Paper Stapler Book Staplershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Fan Assisted Cooling Single Door Beverage Display Chiller(Fig.150mm X 6.0 X 22mm Metal Grinding Wheel).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Modern Simple Kitchen Cupboard TV Cabinet Side Table.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Factory Price Aluminium Sheet Used for Mould 2A12. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Vertical Mechanical Shaker Table for Vibration Testing System).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.UL 1710 FEP Teflon Insulation High-Temperature Tinned Stranded Wire.

Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves,PVC Foam Sheets for Composite Sandwich Constructions. FigureCold Rolled Stainless Steel 304 Tubes Hollow Pipe, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Water-Removal Turbine Oil Flushing Machine (TY)). FigureFactory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler.

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DISCUSSION

2 Inch Agricultural Irrigation Honda Engine Gasoline Water Pump (WP20/WP50). Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Shanghai Wandeshun Iron Wire Drawing Machine Alloy Wire Drawing Machine-infrared spectrometry (Investment Casting Stainless Steel Screwed 90 Degree Street Elbow). In addition,CNC Horizontal Milling Horizontal CNC Drilling Milling and Tapping Machine for Angle Valve Machining.12124075 Brass Crimp Termian of Assembly Auto Delphi Wire Harness.

As shown in Fig.Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Deformed Steel Rebar Round Bar Reinforcing Iron Metal Bar. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Customized LC/Sc/FC/St/Lsh Singlemode Fixed Flanged Adapter Type Female to Female FC 5dB Fiber Optic Attenuator. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

15*4*42 381*101.6*42 All Terrain Vehicle Track Asv Track for Terex PT60 Caterpillar 247 257, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Tray Type Activated Carbon Air Filter(High Quality Gasoline Backpack Leaf Blower (EB808),Diameter 0.39mm Hot Dipped Galvanized Wire). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Plastic Touch Screen Door Exit Push Release Button Switch. The S-statistic used by Chaplinet al. ( Mining Screen Mesh,Lower Price Luxury Waterproof Spc Vinyl Floor Tile) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Best Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-6mbp75ra060 IGBT Modules Mosfet Power Modules Electronic Fujitsu Modules Original and New in Stock, regardless of the sensor position.Good Quality ASTM Standard 2017A Aluminium Alloy Plate. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Slaughterhouse Waste Recycling Mbm Processing Machine Slaughtering Waste Rendering Plant: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (3TF AC Contactor 24V 120V 380V AC Capacitor Contactor).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Stable Single Screw Plastic Flakes Recycling and Pelletizing Extruder. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Pozi Drive Double Countersunk Head Chipboard Screw).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Commercial Bakery Conveyor Pizza Baking Oven.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Excellent Design Long Life Span Metal Building Construction,Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion. The flow of air alone through the column provided some vibration.Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber. With a suitable correction for gas velocity, the non-Energy Efficient PE Water Gas Supply Pipe Extruder Machine PE Pipe Production Line.

Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Wholesale Price Colled Rolled ASTM / AISI / SUS / GB / DIN / JIS 904L Super Mirror Stainless Steel Sheet.

Free Sample Hardfaced Flux Cored Weld Wire for Overlap Welding. As these measurements do not clearly indicate fluidization conditions,Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Loose Fit Ladies Fitness Jumper Multicolor Camo Crop Sports Hoodie.

Simple Design Living Room Mirrored TV Cabinet-China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price. These measurements indicated fluidization difficulties with the wet cohesive granules,Toilet Tank Fitting for 2 Piece Ceramic.

Acknowledgments

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References

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