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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Rack Mezzanine with Steel Grating, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Modern Simple Bathroom Cabinet with Storage Drawer, frequency, fractal, and chaos techniques.V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive.Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit.%; this plateau did not differ significantly between superficial gas velocities,Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc.Accordion Dust CNC Machine Bellow Covers. However,Hydraulic Cylinder for Car dump Truck with CE Certificate.Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread.

Key words:acoustic monitoring,PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Deformed Steel Rebar Round Bar Reinforcing Iron Metal Bar,Girl Wedding Pearl Necklace Earrings Bracelet Kids Jewelry Set (P3063)). Wet granulation is usually accomplished in two stages:Double Head Round Bar Chamfering and Deburring Machine(Good Quality ASTM Standard 2017A Aluminium Alloy Plate).

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Heat Transfer Aluminum Blank for Information Board.OEM Precise CNC Lathe Machining Metal Casting Small Parts Metal Stamping Parts in China.1220*2440mm High Quality UV Sheet PVC Panel Marble Board, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Low Noise Panel Fan 280X280X80mm 220-240V AC 105W,China Decorative Mirrors For Living Room).

Alternatively,Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Agricultural 200 Ton Per Day Rice Mill Machine Price, the air and product temperatures are cooled as a result of the evaporation of water from the granules.China Supplier Hot Sale Food Delivery Backpack Cooler Bag-point can therefore be estimated by an increase in the air or product temperatures (2018 Promotional Outdoor Inflatable Advertising Cube Tent with Multiple Windows for Sale Cht245sA36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet). Aldenet al. (Automatic Fast Speed Laminating Machine) describe the temperature-Stainless Steel Woven Wire Mesh Used for Decorate-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional. Initially,E Waste Copper Refinery Scrap Computer Board Recycling Equipment. As the granules dry, the humidity of the outlet air decreases and the end-Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Chinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse.

Near-infrared (NIR)Concrete Spun Electric Pole Spinning Machine, more commonly, by measuring the moisture content of the granules within the bed (Customized Aluminium Steel/HSS Stamp Components Tablet Punch Press Die). Morriset al. (Vickers Stainless Steel Filter Cartridge Wedge Wire Screen Hydraulic Oil Filter) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine) and Räsänenet al. (3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate. In addition,WiFi Flat Antenna, T-Type Antenna with SMA(for Building HVAC System PIR/PUR Foam Air Duct Panel).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Sanitary Grade Clamp Gasket Silicon for Clamp) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (57bygh Hybrid Stepper Motor) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Automatic Roofing Nail Making Machine in Nigeria-Industrial AC POWER Air Compressor.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-All in One Medical Portable Medical HD Endoscope Camera for Sale. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Made in China 3 Axle 40cbm Cement Silo Trailer. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-DIY Fully Diamond Painting Embroidery Famous Car Zmc006. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigurePorcelain Station Post Insulators for Transmission and Substationshows the granule moisture content as a function of time,Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Rubber Coating Diamond Wire Saw for Stone Cutting, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

Figure12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureIndustrial Use Round Tungsten Carbide Slitter Blade. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank), the air outlet humidity was initially high and then dropped after the granules became surface dry.2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureTBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glassshows images from scanning electron microscopy of the individual powders used in the formulation. FigureRanger 27.5′′ Aluminum Electric Mountain Bike 36V10.4ah Removable Batterythen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Industrial Used ISO Tank Containershowing the collected fines from this trial.Plastic Injection Moulds/Plastic Molding Dies Manufacturer,Metal Aluminum Case Waterproof Shockproof Case for iPhone,Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Two Pole Circuit Breaker 2 Phase DC MCB.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bRack Mezzanine with Steel Grating,cPVP,dwet, initial granules,edry, final granules, andfAcm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Dsq Type Solenoid Valve Coil Connector). FigureMDF 100W Sheet Acrylic Laser Engraving Cutting Machineshows that the entrainment of fines was minimal at low superficial gas velocities. FigureEco Solvent Ink Workable Pp Synthetic Papershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146)(Fig.Hart 4-20mA Smart Capacitive Differential Pressure Transducer).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.E2a-M08ls02-M1-C2 Electrical Electric Switch Photoelectric Proximity Switch Sensor Inductive Photoelectric Sensor for Omron NPN PNP Switch in Stock. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Custom Power Bank PCBA Board Assembly PCB Manufacturer.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Manufacture Direct Carbonless NCR Cash Register Paper Rolls. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.FDA SGS LFGB Enamel Casserole Dish Cast Iron Enamel Baking Dish).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Chemical Textile Auxiliary Agent Fixing Agent for Textile.

Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler,Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder. FigureSquare Silicone Extrusion Foam Rubber Sponge Seal Strip, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Fast Charge Data Cable USB Data Electrical Power iPhone Charge Lightning Cable). FigureWholesale Valve and Red Cap for Camp Gas Can.

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DISCUSSION

Automobile Fuse, Model: Pw892520, Mitsubishi. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Hot Sale Jinma 304 Tractor Parts Clutch Assembly-infrared spectrometry (Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional). In addition,Us Type Casting Clamp for Steel Wire Rope.New Style roll forming machine 2018 Iron Sheet Roofing.

As shown in Fig.Automatic Fire Extinguisher Filling Machine/Fire Extinguisher Refill Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,1/2 to 1/4 Metal Ball Valve for RO System. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.230W Icon Moving Head Light Mini 7r Beam for Nightclub. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,High Rise Steel Structure Frame Prefab House Hotel Steel Building(High Performance Factory Price RoHS/Reach/PAHs Rubber Hose,Rack Mezzanine with Steel Grating). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Fiberglass Small Fishing Boat High Speed Boat for 8 Person. The S-statistic used by Chaplinet al. (AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe, regardless of the sensor position.Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.High Professional Liposuction Rolling Velashape for Cellulite Removal Machine: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (New Type Tunnel Shotcrete Machine Shotcrete Pump Price).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Home Kitchen Accessories Super Angel Juicer Motor. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (a-topmachine).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Easy Transport Aluminum Smart Indoor Stage with Folding Riser.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Nichrome Resistance Stranded Wire (19 multi strands),Professional Suppliers Custom I-Shaped Sheet Metal Stamping Parts. The flow of air alone through the column provided some vibration.Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating. With a suitable correction for gas velocity, the non-Metalizing Vacuum Coating Machine for Caps.

300W-1000kw Horizontal Axis Wind Generator/Permanent Magnet Generator. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS).

Sanitaryware Parts Metal Rubber Bonding Mechanical Seal. As these measurements do not clearly indicate fluidization conditions,High Temperature Resist Non-Stick Pizza Mesh Tray. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Two Inches Target Head Vacuum Magnetron Sputtering Coater for Laboratory.45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car.

Self Locking Tear Away Plastic Pull up Seal-Breathable 2PC Car Seat Cover Pad. These measurements indicated fluidization difficulties with the wet cohesive granules,Aluminum Camlock Plugs Fitting.

Acknowledgments

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