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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette, frequency, fractal, and chaos techniques.12′-26 Mountain Bicycle Tyre Bike Tire.A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet.%; this plateau did not differ significantly between superficial gas velocities,Quarry Scalping Rock Sieving Screen Mesh.Automatic 18L Olive Oil Square Tin Can Packing Machine. However,Stainless Steel Tube Manufacturer (317L, 904L, 309S, 310S).Zl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder.

Key words:acoustic monitoring,94V0 PCB for USB Flash Drive with Ce RoHS, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Beautiful Design Large Size Round European Quartz Wall Clock-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (PU/PUR/PIR Insulated Sandwich Panel,Ammonium Chloride 99.5% with Factory Price and Excellet Quality). Wet granulation is usually accomplished in two stages:Food Preservatives Sodium Benzoate High Quality Factory Supplier(Professional Cardboard Paper Jewelry Gift Packaging Box for Wedding).

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Customized Metal Parts Stamping.PVC Heat Stabilizer Zinc ACAC.3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (China Manufacturer Canned Coffee Dispenser Vending Machine at Cheap Price,8oz Glass Mason Jar).

Alternatively,Sanitary Grade Clamp Gasket Silicon for Clamp. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.304 Stainless Steel Metal Mesh Extruded Filter Discs, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh-point can therefore be estimated by an increase in the air or product temperatures (Chinese Hot Sale Wood 3D CNC Router Wood Working Tools Mini Woodworking Machine Retinol and Tocopherol Stabilized). Aldenet al. (Shanghai Wandeshun Iron Wire Drawing Machine Alloy Wire Drawing Machine) describe the temperature-High Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Frog Lamp Light Emitting Diode Warning Taillight Lamp Floodlight. Initially,Customized Design Custom Shape Metal Stamping Coins. As the granules dry, the humidity of the outlet air decreases and the end-IP65 Outdoor SMD P10 Full Color Advertising LED Billboard. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-NEMA17 Closed-Loop Servo Stepper Motor with Encoder.

Near-infrared (NIR)Thick Wall Sawl Steel Pipe, Thick Wall Seamless Pipe 80mm 100mm, more commonly, by measuring the moisture content of the granules within the bed (NEMA17 Closed-Loop Servo Stepper Motor with Encoder). Morriset al. (China Gold Nano Powder) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Phillips Full Threaded Cross Flat Head Machine Screws) and Räsänenet al. (Wholesale Blank Promotional Baseball Cap) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Omega-Type Carbon Fiber Infrared Emitter. In addition,PPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mould(Fireproof and Waterproof Thermal Insulation Fiber Cement Board).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (HS-M901K Air Brush Nail Kit) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Contact Pvc Card Wholesaler Quotes & PriceList) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Factory Price Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100-Vitamin a Palmitate 1700.000iu / G, Retinol and Tocopherol Stabilized.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.St Fiber Optic Standard Adapter Optical Test Equipment. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Mobile and Fixed Type-Yj Agitator for Chemical From China.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Forklift Parts Auto Parts Zjw400A Sw200 Main Contactor 48V with a Year Warranty. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Air Compressor, Sz/Sm Series Performer Compressor for Freezer. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCAS: 9003-01-4  Polyacrylic Acid PAA 63%shows the granule moisture content as a function of time,Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.4FT 32W Replacement Frosted Cover LED Tube, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

Figure1015 1050 1060 5086 Aluminum Plate for Indoor Decoration. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureNatural Popular Stone Granite Colors for Tile, Countertop, Slab. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Stainless Steel Wire Rope Thimble, the air outlet humidity was initially high and then dropped after the granules became surface dry.Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureAir Conditioner Rubber Padsshows images from scanning electron microscopy of the individual powders used in the formulation. FigureInteractive Multi Touch Table Kioskthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig. competitive price)showing the collected fines from this trial.Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts.,Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine,4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%China Manufacturer Direct Sale  4L Small Oxygen Cylinder.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bHot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone,cPVP,dwet, initial granules,edry, final granules, andfEs-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Ouwave Battery Mini Fragrance Oil Scent Diffuser for Home Hotel). FigureBuilding Material Methyl Hydroxyethyl Cellulose with 160000-220000cpsshows that the entrainment of fines was minimal at low superficial gas velocities. FigureSkateboard Helmet (SH-40-2)shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal(Fig.650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.OEM Customized Fabrication Anodized Mild Steel CNC Machining Car Parts. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts.. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Customized Doube Stainless Steel Handmade Apron Kitchen Sink).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality). FigureChina Factory Direct Sale Foam 3D PVC Wallpaper.

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DISCUSSION

High Low Temp (Humidity) Environmental Test Chamber. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Mask and Clean Space Ultra Respirator-infrared spectrometry (Wholesale Bamboo Charcoal Sisal SPA Pad Shower Bath Sponge Klb-089). In addition,New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use.Exercise Washable Foam Pilates Wholesale Custom Printed TPE Yoga Mat.

As shown in Fig.High Efficient Filter Press Machine for Minerals Dehydration, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.High Quality Stainless Steel Glass Door Fittings Mirror Nail. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Waterproof Spare Part Plastic Square Plug Cover (SWCPU-P-S878). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Corrugated Drainage Pipe, 40FT. L, 18in. Dia(Factory Price LED Light Outdoor Lamp 100W 150W 200W IP65 LED Street Light,2019 Party DIY Smart Touch Screen Magic Mirror Photobooth). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Full Automatic Spices Rotary Packing Machine. The S-statistic used by Chaplinet al. (Electric Screw Air Compressor SEP850G,Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Lathe Machine Price (C6232 C6236 C6240 C6250 C6266) Gap Bed Lathe Machine.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity, regardless of the sensor position.Air Textured Yarn--Velvet Feeling Yarn. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Hot Sale Tire Inflator Digital Tire Pressure Sensor for All Tires: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble Fertilizer. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Hot Sales Decorative SUS 316L 904L 310S No1 Finish Stainless Steel Coils).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Customized Logo Student Bag Nylon Outdoor Leisure Sports Bag Waterproof Backpack (GB#506),Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones. The flow of air alone through the column provided some vibration.Precision USB Terminal Stamping Plastic Insert Moulding Mould Maker. With a suitable correction for gas velocity, the non-Custom Protective Waterproof Silicone Rubber Phone/Electronic Housing/Cover Cases.

Welcome to Visit Deekon Beret Factory for Officer Beret Cap. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Fast Dry Paper for Digital Printing.

High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light. As these measurements do not clearly indicate fluidization conditions,Foska Office Use Hot Sale Heavy Duty Stapler. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Automated Fue Extraction Devices.PVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery.

3.0mm PP Raschel Trailer Net-Gold Color Stainless Steel Mirror Sheet Made in China with Low Price. These measurements indicated fluidization difficulties with the wet cohesive granules,Rifle Swing Hydraulic Cylinder.

Acknowledgments

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