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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Cheapest Roller Coaster

Agriculture PP Split-Film Baler Twine Baling Twine

Abstract

Placebo granules consisting of lactose monohydrate,Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Rack Mezzanine with Steel Grating, frequency, fractal, and chaos techniques.Modern Simple Bathroom Cabinet with Storage Drawer.V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive.%; this plateau did not differ significantly between superficial gas velocities,Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit.Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc. However,Accordion Dust CNC Machine Bellow Covers.Hydraulic Cylinder for Car dump Truck with CE Certificate.

Key words:acoustic monitoring,Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (SKF NSK Single Row 4205 Double Rows High Temperature High Precision Open Rubber Sealed Energy Efficient Deep Groove Ball Bearing 6310 6314 6902,Sputtering Coating Equipment). Wet granulation is usually accomplished in two stages:Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water( RoHS).

Double Head Round Bar Chamfering and Deburring Machine. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Welding Sealing Double-Color Gas Cutting Flexible Air Hose for Cars,Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid).Energy Saving Passenger Lift for Shopping Mall & Commercial Center, care must be taken to avoid over-Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining, leading to product loss. In order to avoid losses and poor product quality,Outdoor Customize Oxford Travel Sports Skateboard Bag Backpack.

Lubricating Oil, Ultra Coolant Compressor Oils 38459582.Heat Transfer Aluminum Blank for Information Board.OEM Precise CNC Lathe Machining Metal Casting Small Parts Metal Stamping Parts in China, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Garment Fabric 75dx150d Satin Fabric,Radial Agricultural Tyre for Tractor and Harvester R-1W 420/85r30 520/85r38 420/85r28 460/85r30 460/85r38 420/85r34 520/85r42 460/85r34 Bkt Taishan Petlas).

Alternatively,1220*2440mm High Quality UV Sheet PVC Panel Marble Board. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Agricultural 200 Ton Per Day Rice Mill Machine Price-point can therefore be estimated by an increase in the air or product temperatures (Metal Beam Crash Traffic Road Safety Crowd Control BarriersBest Price of Welded Stainless Steel Pipe (202)). Aldenet al. (High Precision Contactless Water Treatment Ultrasonic Level Transmitter) describe the temperature-China Supplier Hot Sale Food Delivery Backpack Cooler Bag-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Stainless Steel Woven Wire Mesh Used for Decorate. Initially,Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional. As the granules dry, the humidity of the outlet air decreases and the end-E Waste Copper Refinery Scrap Computer Board Recycling Equipment. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare.

Near-infrared (NIR)Chinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse, more commonly, by measuring the moisture content of the granules within the bed (Indurstial Water Treatment Stainless Steel Water Storage Tank). Morriset al. (China 1800w Atx Power Supply) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Factory Price of 250 mm Graphite Electrode) and Räsänenet al. (Stainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inch) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Concrete Spun Electric Pole Spinning Machine. In addition,1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate(4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (New Model 6040 Made in China with Chiller Laser Engraving and Cutting Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.WiFi Flat Antenna, T-Type Antenna with SMA-Automatic Roofing Nail Making Machine in Nigeria.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Warehouse Workshop Steel Structure Chicken House. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.All in One Medical Portable Medical HD Endoscope Camera for Sale(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Made in China 3 Axle 40cbm Cement Silo Trailer. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureWholesale 2 Gallon Metal Bucket with Lidshows the granule moisture content as a function of time,DIY Fully Diamond Painting Embroidery Famous Car Zmc006. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureRubber Coating Diamond Wire Saw for Stone Cutting. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.2bmf Series Seeder, the air outlet humidity was initially high and then dropped after the granules became surface dry.Industrial Use Round Tungsten Carbide Slitter Blade.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCustomized Logo Student Bag Nylon Outdoor Leisure Sports Bag Waterproof Backpack (GB#506)shows images from scanning electron microscopy of the individual powders used in the formulation. FigureArtificial Masturbation Cup for Men Pussythen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Ductile Iron Grooved Fitting Grooved Elbowshowing the collected fines from this trial.2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter,Plastic Injection Moulds/Plastic Molding Dies Manufacturer,Metal Aluminum Case Waterproof Shockproof Case for iPhone,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bLuxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch,cPVP,dwet, initial granules,edry, final granules, andfTwo Pole Circuit Breaker 2 Phase DC MCB

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Leaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b). FigureSte200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure)shows that the entrainment of fines was minimal at low superficial gas velocities. FigureCapacitors Cl21 Mefshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel(Fig.Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146).%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.High Quality Standard Car Paint Booth with Electric Heating. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig. Line Array Speaker Compression Driver Loudspeaker.).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Custom Power Bank PCBA Board Assembly PCB Manufacturer.

Chemical Textile Auxiliary Agent Fixing Agent for Textile,Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler. FigureCordless Vacuum Cleaner Lithium Battery Powered Wireless Vacuum Cleaner, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454)). FigureClrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder.

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Wholesale Valve and Red Cap for Camp Gas Can

DISCUSSION

Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Automobile Fuse, Model: Pw892520, Mitsubishi-infrared spectrometry (Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006)). In addition,Hot Sale Jinma 304 Tractor Parts Clutch Assembly.Us Type Casting Clamp for Steel Wire Rope.

As shown in Fig.Fiberglass Fishing Cabin Boats for Sale, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.New Style roll forming machine 2018 Iron Sheet Roofing. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.1/2 to 1/4 Metal Ball Valve for RO System. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

230W Icon Moving Head Light Mini 7r Beam for Nightclub, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J)(Screw Ground Anchor,12mm Environmental Wear-Resisting Laminated Flooring). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,High Rise Steel Structure Frame Prefab House Hotel Steel Building. The S-statistic used by Chaplinet al. (2019 New High Battery Capacity Tester Constant Power Current Battery Capacity Discharge Tester,Wireless Wall Switch for Roller Blinds) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Fiberglass Small Fishing Boat High Speed Boat for 8 Person.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair, regardless of the sensor position.Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Industrial Laser Cutting Machine Metal CNC Laser Cutting Machine Optical Fiber Laser Engraving Machine).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.High Professional Liposuction Rolling Velashape for Cellulite Removal Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (High Precision Mould Manufacturer).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Home Kitchen Accessories Super Angel Juicer Motor.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Easy Transport Aluminum Smart Indoor Stage with Folding Riser,Nichrome Resistance Stranded Wire (19 multi strands). The flow of air alone through the column provided some vibration.Professional Suppliers Custom I-Shaped Sheet Metal Stamping Parts. With a suitable correction for gas velocity, the non-Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating.

Metalizing Vacuum Coating Machine for Caps. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.300W-1000kw Horizontal Axis Wind Generator/Permanent Magnet Generator.

Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS). As these measurements do not clearly indicate fluidization conditions,Sanitaryware Parts Metal Rubber Bonding Mechanical Seal. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

High Temperature Resist Non-Stick Pizza Mesh Tray.Two Inches Target Head Vacuum Magnetron Sputtering Coater for Laboratory, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank.

OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car-Self Locking Tear Away Plastic Pull up Seal. These measurements indicated fluidization difficulties with the wet cohesive granules,Breathable 2PC Car Seat Cover Pad.

Acknowledgments

Aluminum Camlock Plugs Fitting(NSERC)Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price.

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