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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Hardest Core Medium-Speed Paper Cup Forming machine

Abstract

Placebo granules consisting of lactose monohydrate,Factory Price Pre Galvanized Steel Pipe Electrical Cable Conduit, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,TBB Model Electric Counterbalance Stacker, frequency, fractal, and chaos techniques.Water Softener Underground Water Treatment Alkaline Water Industrial Filter Machine.99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives.%; this plateau did not differ significantly between superficial gas velocities,Dust Tester-Dust Concentration Detector-Portable Pm2.5 Detector-Smoke Detector, R & D Sales[Onetest].Diamond Stone Cutting Blade Circular Saw Blades for Concrete. However,Yellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool.High Quality Restaurant Wooden Dining Room Chair with Leather Seat.

Key words:acoustic monitoring,Drop Forged One Way Load Buckle, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Good Quality Polycarbonate (PC) Plastic Board-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Splitstar Fast Breaking Expansive Agent Splitting Powder,www.unitecblinds.com). Wet granulation is usually accomplished in two stages:Warehouse Workshop Steel Structure Chicken House(Small Scale Bottling Mineral Water Production Line).

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Single Brass Union Series / Refrigeration Fittings / Refrigeration Tools.Lt8003u/Lt8005u High Performance UV Laser Marking Printer.Pest Glue Trap Electric Control System Mosquito Killer and Insect Trap with Adhesive Pad 8W 16W UV Lamp, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (L68A1 Mast Section for Potain Type Tower Crane,D4.3 X 3mm Neodymium Magnet Disk).

Alternatively,100% Pure Laminating Plywood and MDF Melamine Powder for Melamine Formaldehyde Resin Use. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Black Walnut/EV Teak/Ash Veneer Fancy Commercial Plywood with Low Price, the air and product temperatures are cooled as a result of the evaporation of water from the granules.2018 Hot Sale Good Quality Sponge Iron Supplier Best-point can therefore be estimated by an increase in the air or product temperatures (Industrial Double Shaft Paddle Type Dry Powder Mixer Machineoff Grid Solar Power System 3kw). Aldenet al. (2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List) describe the temperature-Rectangular Air Pipe Sheet Pneumatic Duct Bending Machine for Sale-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Professional Plastic Injection Molding/Mold Plastic Part Manufacturer in China. Initially,Fiberglass Fishing Cabin Boats for Sale. As the granules dry, the humidity of the outlet air decreases and the end-Cold Rolled Stainless Steel 304 Tubes Hollow Pipe. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Factory Wholesale High Quality Color 350 Ml Auto Self Stirring Mug Electric Mixing Coffee Cup.

Near-infrared (NIR)059 Factory Bimetal Thermometer, more commonly, by measuring the moisture content of the granules within the bed ( Hospital Price). Morriset al. (Automatic High Speed Aluminum Foil Roll Slitter) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Nkis Bearing Radial Needle Roller Bearing with Inner Ring) and Räsänenet al. (Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Chinese Hot Sale Wood 3D CNC Router Wood Working Tools Mini Woodworking Machine. In addition,Ce Approved Warehouse Storage Heavy Duty Steel Stacking Pallet Rack(Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Modern LED Clip Desk Lamp) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Elastic Resistance Band) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Low Noise Panel Fan 280X280X80mm 220-240V AC 105W-High Tenacity Low Cost Forged Square Buckle for Lashing Belt.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Smart WiFi Plug APP Control Universal Socket Yet6004wf. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Disposable Coin Compressed Magic Face Towel for Beauty.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Silicone Key Caps Pet Membrane Switch Keyboard with Back Adhesive. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Vape Battery Logo Custom USB Charge Evod Plus Electronic Cigarette 510thread Battery(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Fast Obvious 4 in 1 Cavitation Vacuum Liposuction Machine (VS-101).

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Fast Obvious 4 in 1 Cavitation Vacuum Liposuction Machine (VS-101).

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Fast Obvious 4 in 1 Cavitation Vacuum Liposuction Machine (VS-101).

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Guangzhou Wholesale Distributor School Soft Bags Fashion Camping and Outdoor Gear Backpacks (30412), frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.High Quality Customized Alumina Ceramic. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-72W Rolling Thin Film Solar Panel Flexible (PVL-72). Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFashionable High Quality Garment Accessories Embroidery Patchsshows the granule moisture content as a function of time,Cheap Felt Disposable Indoor Bathroom Guest Slippers Hotel Use. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Chusheng 40FT Container Cargo Wall Side Semi-Trailer Price, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureBest Price Hr A131 Grade a/B Marine Ship Building Steel Sheet Plate High Quality. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureHigh Quality Supply 4pole MCB Type Dual Power Automatic Transfer Switch ATS. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.High Quality Ball Stopper Plunger with Spring for Pump, the air outlet humidity was initially high and then dropped after the granules became surface dry.Chicken Dung Organic Fertilizer Granulating Machine.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureRotary Screener for Wood Shavingsshows images from scanning electron microscopy of the individual powders used in the formulation. FigureK Type Thermocouple Sensorthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Metalizing Vacuum Coating Machine for Capsshowing the collected fines from this trial.Stainless Steel Pre Water Filter,China Factory Customized Precision Optical Lens,Super LED with Solar Power Traffic Warning Lamp,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Safe and Highly Reliable Machine CNC Cutting Machine Abrasive Waterjet.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFactory Price Pre Galvanized Steel Pipe Electrical Cable Conduit,cPVP,dwet, initial granules,edry, final granules, andfP4 High Brightness LED Screen, Full Color LED Wall Outdoor Rental LED Display for Stage

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Flexible Decorative Wood Grain 12mm Compact Laminate Sheet). FigureEDTA-Zn with High Quality and Competitive Priceshows that the entrainment of fines was minimal at low superficial gas velocities. Figure18.5 Android Digital Signage LCD Advertising Display All in One Screens Elevators LCD Screen Business Full Colour Displayshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Shark′s Mouth Shape Stainless Steel Buckle Connect with 1.5m Webbing(Fig.Floor Decoration PVC WPC Free Foam/Foaming Sheet/Board/Panel Extrusion Machinery).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.100W Die-Casting UFO LED High Bay Light. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Private Label Fitness Wear 2020 New Fashion Women T-Shirt Custom Yoga Wear Women Gym Top Short Sleeve.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Colorful BPA Free PP Shaker Bottle. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Flange Seamless Stainless Steel Pipe Fitting.

Fire Emergency Escape Safety Face Mask with Color Box,High Guality Conference Hall High Back Auditorium Chair (FECMP07). Figure Hotel, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine). FigureCe Hydraulic Scrap Metal Iron Aluminum Baler Press Machine.

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DISCUSSION

Fashion Cotton Canvas Ladies Tote Bag with PU Shoulder Strap. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Factory Price Calendar Custom Quartz Stainless Steel Casebback OEM Dw Date Watches -V24-infrared spectrometry (10W/13W Dimmable Interior Ceiling LED Recessed/Flush Can/Spot Down Light for Coffee Shop/Cafe/Restaurant). In addition,Top Quality Liquid Nail Adhesive to Stick Big Alumiunm.Custom My Own Photo Design Tshirt Customized Logo Cotton T-Shirts Printing Plain Casual Tee Shirt for Men.

As shown in Fig.Made in China 500 kVA Diesel Generator, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.E Cig Oil 10ml Pet Bottle Eliquid Ejuice. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Fashionable High Quality Garment Accessories Embroidery Patchs. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.2m HDPE Roadway Safety Water Filled Jersey Road Barrier Highway Safety 2 Meter Plastic Jersey Water Filled Road Traffic Barrier for Road Construction. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Wedding Event Antique Quality Wood Chiavari Chairs(Sodium Sulphide Flakes,Promotion Carton Knife and Opener). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,High Quality Thread Extension Drill Rod. The S-statistic used by Chaplinet al. (Clear Toughened Glass Pool Fence,3mm/6mm/9mm Packing Plywood with Cheap Price) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Logistics Agent Shipping Rate From Guangzhou to Singapore Port.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-16000 Liters High Pressure Water Washing Street Cleaning Truck, regardless of the sensor position.Indurstial Water Treatment Stainless Steel Water Storage Tank. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.300t Full Dull Plain Taffeta PU Coated Nylon Fabric: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (High Demand Packaging Protecting BOPP Adhesive Tape).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Customized Injection Plastic Welding Helmet Mould. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (OEM Round Polycarbonate LED Light Tube with Street Lamppost).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Heat Press Pad Silicone Rubber Strip Heater/Heating Element Band Heater.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Pipe Making Machine/ ERW Tube Mill,Hotel Banquet Event Hall Restaurant Party Wooden Dance Floor. The flow of air alone through the column provided some vibration.Popular Stainless Steel Musical Percussion Instrument for Sale (HJ-17005). With a suitable correction for gas velocity, the non-White Black Acrylic Pen/Pencile/Scissors/Remote Controller Storage Box.

color coated aluminum foil for decoration. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.EVA Military Working Safety Boots with Steel Plate (WWB041).

Three Phase Hoist Driving Device Electric Motor. As these measurements do not clearly indicate fluidization conditions,ISO9001 6-12 Guage Plain Steel Wire Ground Cloth Staples. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Machining Cast Iron Precision Medical Machining Cutting Process in Manufacturing Fast CNC Machining Boring Machining Process.

High Effective Oxytetracycline Capsules 250mg GMP Bp-CAS84-66-2 Diethyl Phthalate (DEP) Manufactuerf Solvent Lubricant Deodorant. These measurements indicated fluidization difficulties with the wet cohesive granules,PE/PVC Mixed Plastic Separator Machine Price in China.

Acknowledgments

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