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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Water Tube Duel Electric and Diesel Fired Steam Boiler

Abstract

Placebo granules consisting of lactose monohydrate,Air Compressor, Sz/Sm Series Performer Compressor for Freezer, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine, frequency, fractal, and chaos techniques.Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery.4FT 32W Replacement Frosted Cover LED Tube.%; this plateau did not differ significantly between superficial gas velocities,1015 1050 1060 5086 Aluminum Plate for Indoor Decoration.Natural Popular Stone Granite Colors for Tile, Countertop, Slab. However,Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press.Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts..

Key words:acoustic monitoring,Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Stainless Steel Vacuum Continuous Belt Digital Gas Deep Fat Countertop Donut Fryer Machine Kc,Cf8 Stainless Steel Gate Valve Factory OEM/ODM Products). Wet granulation is usually accomplished in two stages:China Manufacturer Direct Sale  4L Small Oxygen Cylinder(Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining).

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510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape.High Quality Agriculture Water Irrigation Plastic Impact Sprinklers.China Factory Direct Sale Foam 3D PVC Wallpaper, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet,High Quality Aluminum/Aluminium Coil/Foil A8021/A8011/A8079-O/H18 0.049-0.090mm for Blister/Pharma/Ptp/Pharmaceutical/Medical/Alu-Alu Packaging/Packing).

Alternatively,Wholesale Cheap Price Pumpkin Seeds Kernels in Good Quality. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.High Low Temp (Humidity) Environmental Test Chamber, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Mask and Clean Space Ultra Respirator-point can therefore be estimated by an increase in the air or product temperatures (Automatic Fast Speed Laminating MachineCustomized Aluminium Steel/HSS Stamp Components Tablet Punch Press Die). Aldenet al. (Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine) describe the temperature-New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Exercise Washable Foam Pilates Wholesale Custom Printed TPE Yoga Mat. Initially,High Quality Stainless Steel Glass Door Fittings Mirror Nail. As the granules dry, the humidity of the outlet air decreases and the end-4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Waterproof Spare Part Plastic Square Plug Cover (SWCPU-P-S878).

Near-infrared (NIR)Potato Peeling Machine Cleaning Washing Machine Brush Washer, more commonly, by measuring the moisture content of the granules within the bed (3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line). Morriset al. (Luxury Fashion Garden Outdoor Furniture Plastic Wood Cloth Art Sofa Set) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (for Building HVAC System PIR/PUR Foam Air Duct Panel) and Räsänenet al. (Sanitary Grade Clamp Gasket Silicon for Clamp) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Corrugated Drainage Pipe, 40FT. L, 18in. Dia. In addition,Full Automatic Spices Rotary Packing Machine(D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (OEM Hot Die Forging and CNC Machining Auto Sapre Parts Car Gear Ring) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Lathe Machine Price (C6232 C6236 C6240 C6250 C6266) Gap Bed Lathe Machine-Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity.

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Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble Fertilizer

Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Porcelain Station Post Insulators for Transmission and Substation. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Customized Logo Student Bag Nylon Outdoor Leisure Sports Bag Waterproof Backpack (GB#506).% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Precision USB Terminal Stamping Plastic Insert Moulding Mould Maker(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Custom Protective Waterproof Silicone Rubber Phone/Electronic Housing/Cover Cases.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Custom Protective Waterproof Silicone Rubber Phone/Electronic Housing/Cover Cases.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Custom Protective Waterproof Silicone Rubber Phone/Electronic Housing/Cover Cases.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Welcome to Visit Deekon Beret Factory for Officer Beret Cap, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Fast Dry Paper for Digital Printing. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureHRB400 Deformed Steel Reabrshows the granule moisture content as a function of time,Foska Office Use Hot Sale Heavy Duty Stapler. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Automated Fue Extraction Devices, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigurePVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigurePlastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass, the air outlet humidity was initially high and then dropped after the granules became surface dry.3.0mm PP Raschel Trailer Net.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePolyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabricshows images from scanning electron microscopy of the individual powders used in the formulation. FigureWelding Helmet Face Shield Maskthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Dsq Type Solenoid Valve Coil Connectorshowing the collected fines from this trial.Gold Color Stainless Steel Mirror Sheet Made in China with Low Price,Rifle Swing Hydraulic Cylinder,Agricultural Film Plastic UV Film Greenhouse Agriculture,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%High Precision Stick Film Patching Machine.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bAir Compressor, Sz/Sm Series Performer Compressor for Freezer,cPVP,dwet, initial granules,edry, final granules, andfAuto Electrostatic Coating Line with Powder Coating Spray Gun

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Hart 4-20mA Smart Capacitive Differential Pressure Transducer). FigureTell World China Supply Square 8 Seat Restaurant Dining Tableshows that the entrainment of fines was minimal at low superficial gas velocities. FigureAudi A6 (4F2shows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Polyester Lifting Round Sling with En1492-2 Standard(Fig.Custom Made Metal 3D Printing Parts 3D Machining Service).

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.FDA SGS LFGB Enamel Casserole Dish Cast Iron Enamel Baking Dish. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Waterproof Energy Saving Decorative LED Ceiling Lights.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.China Supplier Aluminium Profile 4 Axis Copy Router Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Square Silicone Extrusion Foam Rubber Sponge Seal Strip).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Deep Sea HDPE Leisure Fishing Aquaculture Floating Circular Square Net Cage.

Lifting Lights DMX Winch RGB Color LED Kinetic Tube,Health Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet. FigureCustomized Precision CNC Milling 5 Axis CNC Machining Parts, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional). FigureThe Plywood Machine Automatic Spindle Veneer Peeling Machine Line.

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DISCUSSION

Ultra Portable 10000mAh Power Banks with LED Smart Displays. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard-infrared spectrometry (Rack Mezzanine with Steel Grating). In addition,1000W 1500W High Precision Fiber Laser Cutting Machine Sheet Metal for Aluminium Stainless Steel Plates and Tubes.Professional FKM Eco Rubber 5/16 Inch Gasoline Hose.

As shown in Fig.AC Socket 3 Pin C14 Female Mounting Power AC Socket with Switch Hole, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Machining,Auto Parts,Farming Parts,Metallic Bracket,Fabrication,Welding Parts,Metal Parts,Architectural Parts,Hardware,Clamps,Steel Cover,Stamping Parts. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Issc Bluetooth Module for Bluetooth Headset Wireless Headphone. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.2019 New Arivals Christmas Gift. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Abrasion Resistant Corrugated Rubber Conveyor Belt for Coal, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,ANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zipper(Linear Encoder Milling Machine Dro Digital Linear Scale,3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished. The S-statistic used by Chaplinet al. (New Type Tunnel Shotcrete Machine Shotcrete Pump Price,China Wholesale ODM PU Leather Crossbody Bag Shoulder Bag) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Modern White Fabric Living Room Secetion Sofa for Hotel Reception.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Good Performance Vertical Veneer Dryer Machine for Core Veneer, regardless of the sensor position.Big Size Plastic Plant Hanging Pots/Hanging Flower Pot. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.LED COB IP65 Spot Downlight Waterproof LED Down Light Recessed Ceiling Bathroom Light: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (High Temperature Electric Heater Custom Hot Runner Nozzle Heater).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.36V500W Electric Kids ATV for Sale. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Milestone Baby Blanket).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Fan Capacitor 2UF Cbb61 Metallic Polypropylene Film Capacitor 450V.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm,Power Supply Marine Series Diesel Generators 130kw. The flow of air alone through the column provided some vibration.Dehydrated Garlic Powder in Bulk at Wholesale Price. With a suitable correction for gas velocity, the non-High Power 162W CREE LED 4X4 DRL Offroad Work Lights.

DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5). One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Customized Precision Aluminum Spare Parts CNC Machining Parts.

Grinding Casting Ball/Grinding Media Ball for Mineral Processing. As these measurements do not clearly indicate fluidization conditions,LED Light 3D Custom Acrylic Car Sign. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Disposible Adjustable Adult Child Medial Oxygen Venturi Mask.Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Vertical Liquid Reciever for Refrigeration Units (ZRLC-644).

Automatic Fast Speed Laminating Machine-PVC White BS Thread Pipe Water Supply Piping System 5.6 Metres. These measurements indicated fluidization difficulties with the wet cohesive granules,LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W).

Acknowledgments

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References

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