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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Ce Hho 6.0 High Pressure Car Cleaning Machine

Abstract

Placebo granules consisting of lactose monohydrate,Mudan 116HP Mitsubishi Rosa Copy 19 Seats Minibus, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,70GSM 80GSM Customize A4 Copy Huijun Paper for Office Supply, frequency, fractal, and chaos techniques.Welded Gabion Hot-Dipped Galvanized with Hihg Quality.Fashion Designer PU Shoulder School Backpack Bag Women.%; this plateau did not differ significantly between superficial gas velocities,Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof.SMC Af2000-02 Air Filter Regulator Lubricator. However,Food Grade Tannic Acid with Best Price 70% 80% 99%.Factory Supply Battery LED Barrier Warning Strobe for Car Truck.

Key words:acoustic monitoring,Waste Fabrics Chemical Fiber Cutting Machine Old Clothes Cutting Machine Cutter Acrylic/ Polyester Fiber Garnetting Machine Textile Waste Cutting Machine, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Made in China 500 kVA Diesel Generator-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Leaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b,Reducing Sliding Window Door Guide Teflon Roller Pulley). Wet granulation is usually accomplished in two stages:Max-824 Ladies Women Girl Custom Make Bridal Prom Party Wedding Gown Evening Dress(Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure)).

Low Pressure Die Casting Diecast Aluminum Box. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven,Electricity Strain Composite Silicone Suspension Rod Insulator).HP UHP Carbon Graphite Electrode for Electric Arc Furnace Smelting, care must be taken to avoid over-19X15W Big DMX Professional Stage LED Moving Head B-Eye K10, leading to product loss. In order to avoid losses and poor product quality,Portable Patio Party Bar Drink Cooler Cart.

Alstom Valve Optipow105 135 Diaphragm.High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains.Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Color Painted Aluminium Coil for Car License Plate,High Purity APP Monitoring Medical Psa Oxygen Generator).

Alternatively,8X8 Self-Locking Push Switch 6 Pin Push Button Switch. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder, the air and product temperatures are cooled as a result of the evaporation of water from the granules.L68A1 Mast Section for Potain Type Tower Crane-point can therefore be estimated by an increase in the air or product temperatures (Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making MachineryHigh Quality Standard Car Paint Booth with Electric Heating). Aldenet al. ( Line Array Speaker Compression Driver Loudspeaker.) describe the temperature-4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger. Initially,P2.571 Indoor Digital Advertising Floor Standing LED Poster Display. As the granules dry, the humidity of the outlet air decreases and the end-Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-High Quality and Low Price EDTA-Fe.

Near-infrared (NIR)Fashion White Color Acrylic Plastic Resin X Cross Back Chair, more commonly, by measuring the moisture content of the granules within the bed (Excellent Design Long Life Span Metal Building Construction). Morriset al. (Car Dvr Wifi Dual Camera) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Cordless Vacuum Cleaner Lithium Battery Powered Wireless Vacuum Cleaner) and Räsänenet al. (Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454)) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine. In addition,Corrugated Plastic Lawn Signs(Automatic Vertical 10heads Weighting and Packing Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006)) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Italian Leather Strap) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Stainless Steel Insulated Casseroles Hot Pot-Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Fiberglass Fishing Cabin Boats for Sale. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Ce Certified Welding Table HD-100 for Heavy Industry Welding, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Custom Connecting Fittings Type Bolt and Fastener. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure2019 New High Battery Capacity Tester Constant Power Current Battery Capacity Discharge Testershows the granule moisture content as a function of time,Fully Automatic Corrugated Box Making Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureEDTA-Zn with High Quality and Competitive Price. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigurePlastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel, the air outlet humidity was initially high and then dropped after the granules became surface dry.China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureDn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Watershows images from scanning electron microscopy of the individual powders used in the formulation. FigureBedroom Furniture Pocket Spring with Wave Foam Mattressthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.UV Laser Marking Machine with Ce FDAshowing the collected fines from this trial.Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can,High Precision Sf0499 Augular Ball Bearing Automotive Bearing,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Glass Transport Using High Hardness Crane Arm for Sale.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bMudan 116HP Mitsubishi Rosa Copy 19 Seats Minibus,cPVP,dwet, initial granules,edry, final granules, andfPopular Facial Mask Acrylic Cosmetic Display for Show Case

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler). Figure ALUMINUM GAS VALVEshows that the entrainment of fines was minimal at low superficial gas velocities. FigurePowerful Cellphone Mobile Phone GPS GSM WiFi Signal Signal Jammer/Blocker /Interceptor/Isolatorshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.2019 Party DIY Smart Touch Screen Magic Mirror Photobooth(Fig.Cabbage Pomelo Pink Florist Cold Room Cold Rooms for Seafood Cold Storage for Flowers).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.304 Stainless Steel Metal Mesh Extruded Filter Discs. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Light Roof Prefabricated Steel Structure for Parking.

12V torque DC gear motor for electric lawn mowers,Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). Figure18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Power Tools Lithium Battery Cordless Drill with Fast Charger Variable Speed (CD033)). FigureIndustrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.

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Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess

DISCUSSION

Square Silicone Extrusion Foam Rubber Sponge Seal Strip. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Tn Digit Custom LCD 7 Segment LCD-infrared spectrometry (Waste Used Vacuum Pyrolysis Tyre Hydraulic Oil Filtration Gear Oil Purification Regeneration Machine). In addition,HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers.OEM Foundry Parts Water Glass Sand Casting Excavator Parts.

As shown in Fig.1.8m/6FT USB 3.1 Type C Male to HDMI Male Cable, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.1390 CO2 Laser Engraving and Cutting Machine for Plastic. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Hot Sales Rubber Shock Absorber Motorcycle. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Sanitary Ware Brass Bath Shower Faucet (AF2576-2), the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM(Custom Printed Cotton Fashion Graffiti Sports Sock Men,High Precision Sf0499 Augular Ball Bearing Automotive Bearing). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag. The S-statistic used by Chaplinet al. (Hot Sale Jinma 304 Tractor Parts Clutch Assembly,Brass Mold Female Insert Quick Coupler) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Sanitary Grade Manhole Cover with Stainless Steel Handwheel.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt, regardless of the sensor position.Electric Portable Pipe Beveling Chamfering Milling Machine. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.3mm/6mm/9mm Packing Plywood with Cheap Price: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Coal Mine Tear Resistant Steel Cord Conveyor Belt).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Dmais Newest Design Electric Lamination Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (CO2 Laser Machining Parts for Laser Engraving Machine).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope,Food Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H). The flow of air alone through the column provided some vibration.Kaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh. With a suitable correction for gas velocity, the non-23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.

High Quality Custom Plain Shirting 100% Cotton Fabric. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY.

Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles. As these measurements do not clearly indicate fluidization conditions,Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding.Professional Hair Removal IPL Shr Machine with FDA, Medical Ce, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Round Cosmetic Powder Puff, Face Makeup Sponge.

Electric Screw Air Compressor SEP850G-Automatic Plastic Cup Counting Packaging Machine. These measurements indicated fluidization difficulties with the wet cohesive granules,Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt.

Acknowledgments

Hot Sale Supply Stainless Steel PTFE Teflon Hose(NSERC)Lost Wax Casting/Investment Casting Parts Manufacture in China.

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