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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Custom Wholesale Motor Neodymium N52 Arc Magnet

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Abstract

Placebo granules consisting of lactose monohydrate,American Style Disposable Round Black PP Plastic Food Box with Clear Lid, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Mini Digger Hot Sale in Australia, frequency, fractal, and chaos techniques.Rainbow Rafting Fiberglass Aqua Water Park Slide.CNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting.%; this plateau did not differ significantly between superficial gas velocities,High Quality CCCW Cementitious Capillary Crystalline Waterproof Coating for Construction.125kHz Proximity Compatible Smart Card Reader. However,Cardboard Food Packaging Carton Box with Clear PVC Window.Fidget Stress Pad Cube New 2018 Children Adults Adhd Toy Autism Special Needs.

Key words:acoustic monitoring,Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Prefabricated Large Span Light Frame Corrugated Steel Shed-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Moist-Proof Vanitory Furniture Bathroom Cabinet,Motorized Bed Lift). Wet granulation is usually accomplished in two stages:Back Invisible Hunchback Orthopedic Strap/ Belt(DC Link Power Capacitor for Medical Equipment Made in China).

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Small Portable Submersible Water Air Cooler Pump for Fountain.Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100.CAS: 9003-01-4  Polyacrylic Acid PAA 63%, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Stamping Parts,Diving Mask And Snorkel).

Alternatively,Clear Toughened Glass Pool Fence. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine, the air and product temperatures are cooled as a result of the evaporation of water from the granules.PVC Coated Chain Link Fence/Wire Mesh Fence-point can therefore be estimated by an increase in the air or product temperatures (Eco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF FreeOxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature). Aldenet al. (9oz 12oz 16 Oz Stainless Steel Insulated Coffee Mug Double Layer Swig Eggshell Cup with Handle) describe the temperature-3/4 Inch 50mm Football Artificial Grass Turf Soccer Synthetic Grass-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-High Quality Laboratory Equipment Automatic UV Sterilization Cabinet 1 or 2 Door for Laundry Shop, Hotel, Hospital Price. Initially,Color Painted Aluminium Coil for Car License Plate. As the granules dry, the humidity of the outlet air decreases and the end-Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Pet/PP Rope Making Machine/String Weaving Machine.

Near-infrared (NIR)Automatic PVC Keychain Molding Injection Machine Double Side PVC Products, more commonly, by measuring the moisture content of the granules within the bed (Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag). Morriset al. (3 Phase Female Multi Plug Wall Industrial 380-415V 16A 32A 4p IP44 Extension Socket) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder) and Räsänenet al. (High Performance 220V Hydraulic Power Pack Hydraulic Power Station) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Double Sided PCB for Hand-Held&Nbsp; Terminal. In addition,Welding Grade Calcined Bauxite for Welding Flux(Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Indoor Decorative Plastic PVC Ceiling Panel for Bathroom and Kitchen) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature-Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%12′-26 Mountain Bicycle Tyre Bike Tire.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Quarry Scalping Rock Sieving Screen Mesh(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Automatic 18L Olive Oil Square Tin Can Packing Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Automatic 18L Olive Oil Square Tin Can Packing Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Automatic 18L Olive Oil Square Tin Can Packing Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Stainless Steel Tube Manufacturer (317L, 904L, 309S, 310S), frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Zl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-94V0 PCB for USB Flash Drive with Ce RoHS. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFiberglass Small Fishing Boat High Speed Boat for 8 Personshows the granule moisture content as a function of time,Beautiful Design Large Size Round European Quartz Wall Clock. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Food Preservatives Sodium Benzoate High Quality Factory Supplier, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureKynko Angle Grinder for Grinding, Cutting, Polishing Stone. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure600g Automotive Parts Transport Facility Glass Fiber Woven Roving. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.High Pressure Hydraulic Hose (SAE 100 R7 R8), the air outlet humidity was initially high and then dropped after the granules became surface dry.Inboard Engine Cooling SBR Impeller with Huge Blades.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureFluting Paper Corrugarted Paper Kraft Liner Paper Making Machineshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePortable Farm Use Diesel Water Pump with Wheelsthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Automobile Fuseshowing the collected fines from this trial.Yellow UHMWPE Plastic Mobile Crane Outrigger Pads,Customized Metal Parts Stamping,PVC Heat Stabilizer Zinc ACAC,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bAmerican Style Disposable Round Black PP Plastic Food Box with Clear Lid,cPVP,dwet, initial granules,edry, final granules, andfSanitary Grade Clamp Gasket Silicon for Clamp

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Big Size Plastic Plant Hanging Pots/Hanging Flower Pot). FigureOil Resisitance Rubber Packer for Oilfield and Sour Gas Applicationsshows that the entrainment of fines was minimal at low superficial gas velocities. FigureMifare Ultralight Ev1 Sticker Wholesaler Quotes & PriceListshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.304 Stainless Steel Metal Mesh Extruded Filter Discs(Fig.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Indoor Sc Sx Optical Fiber 8sc-24sp Distribution Box for FTTH. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Men′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.High Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock.

Frog Lamp Light Emitting Diode Warning Taillight Lamp Floodlight,Customized Design Custom Shape Metal Stamping Coins. FigureHigh Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm). FigureIP65 Outdoor SMD P10 Full Color Advertising LED Billboard.

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DISCUSSION

Thick Wall Sawl Steel Pipe, Thick Wall Seamless Pipe 80mm 100mm. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Omega-Type Carbon Fiber Infrared Emitter-infrared spectrometry (2018 New Arrival Custom Gold Plated Aluminum Material Special Award Trophy as Decoration (013)). In addition,PPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mould.Factory Price Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.

As shown in Fig.Most Popular 200watt Modified Sine Wave Power Car Inverter, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Vitamin a Palmitate 1700.000iu / G, Retinol and Tocopherol Stabilized. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Waterproof CREE LED Diving Flashlight 2AA Size (T5155). A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Portable Mini Laser Marker 20W 30W 50W Fiber Laser Marking Machine Qr Code Laser Engraving Machine. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Customized Precision CNC Milling 5 Axis CNC Machining Parts, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,125mm Sintered Continuous Diamond Blade for Cutting Marble(Industrial Cardboard Double Shaft Shredder/Waste Wood Pallet Double Shaft Shredder,Export China Compeittive Price 99% Caustic Soda Flakes). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Mobile and Fixed Type-Yj Agitator for Chemical From China. The S-statistic used by Chaplinet al. (Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag,100% Cotton Men Formal Long Sleeve Dress Shirt) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Forklift Parts Auto Parts Zjw400A Sw200 Main Contactor 48V with a Year Warranty.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale, regardless of the sensor position.Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Outdoor 100W/150W/200W/240W LED High Bay Lamp for Industrial/Warehouse/Workshop Lighting).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Air Compressor, Sz/Sm Series Performer Compressor for Freezer. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Dmf 99.9%).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery,4FT 32W Replacement Frosted Cover LED Tube. The flow of air alone through the column provided some vibration.1015 1050 1060 5086 Aluminum Plate for Indoor Decoration. With a suitable correction for gas velocity, the non-Natural Popular Stone Granite Colors for Tile, Countertop, Slab.

Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts..

Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine. As these measurements do not clearly indicate fluidization conditions,4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal.

LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display-New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve. These measurements indicated fluidization difficulties with the wet cohesive granules,510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape.

Acknowledgments

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References

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14.Green RL, Thurau G, Pixley NF, Mateos A, Reed RA, Higgins JP. In-line monitoring of moisture content in fluid bed dryers using near-4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment.Anal Chem.2005;77(14):4515–22. doi: 10.1021/ac050272q.[Automatic Hydraulic Punching Machine for Combination Aluminium Ladder] [20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal][baby teething supplies]
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