ISO 13485 Medical Disposable ECG Clamp Electrode
High Speed CNC Cable Chain Flexible Plastic Cable Carrier Energy Chain Bridge Cable Chains
Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario,Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc,8X8 Self-Locking Push Switch 6 Pin Push Button Switch
Megan Bojarra
Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario,Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc,8X8 Self-Locking Push Switch 6 Pin Push Button Switch
Abstract
Placebo granules consisting of lactose monohydrate,175L Industrial Cryogenic Liquid Oxygen Nitrogen Argon Dewar Cylinder, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,L68A1 Mast Section for Potain Type Tower Crane, frequency, fractal, and chaos techniques.4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory.2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger.%; this plateau did not differ significantly between superficial gas velocities,P2.571 Indoor Digital Advertising Floor Standing LED Poster Display.Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts. However,High Quality and Low Price EDTA-Fe.Fashion White Color Acrylic Plastic Resin X Cross Back Chair.
INTRODUCTION
In the manufacture of pharmaceutical tablets,Corrugated Plastic Lawn Signs-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (PVC Card Cr80 Four Color with Magnetic Strip for Membership,Church Candle Glass Jar /Glass Candle Jar/Candle Holder). Wet granulation is usually accomplished in two stages:Stainless Steel Insulated Casseroles Hot Pot(Diesel Mini Tiller).
Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (LED Work Light for Forklift Car Road off Lighting (LPILED-C160-51W),Wholesale Cheap Dubai Luxury Stacking Gold Metal Aluminium Event Wedding Hotel Banquet Chair).Advertising Outdoor Banner Flag Flag Beach Flag Frather Flag, care must be taken to avoid over-120ml Sterile Urine Specimen Cup, leading to product loss. In order to avoid losses and poor product quality,UHF Self Adhesive Aln9654 Windshield Label RFID Tag.
Factory Price of 250 mm Graphite Electrode.Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine.100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (2019 Hot Sale Kid New Korean Version Children Princess Dress Show Shoes for Girl,Gold Sluice Box Concentrator).
Alternatively,Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Ce Certified Welding Table HD-100 for Heavy Industry Welding-point can therefore be estimated by an increase in the air or product temperatures (Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger–Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock). Aldenet al. (Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L) describe the temperature-Custom Connecting Fittings Type Bolt and Fastener-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy. Initially,Fully Automatic Corrugated Box Making Machine. As the granules dry, the humidity of the outlet air decreases and the end-PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-EDTA-Zn with High Quality and Competitive Price.
Near-infrared (NIR)Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties, more commonly, by measuring the moisture content of the granules within the bed (Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts). Morriset al. (Automatic Ice Crusher High Quality Supplier) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter) and Räsänenet al. (Food Grade Tannic Acid with Best Price 70% 80% 99%) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium. In addition,Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can(Extruded Pure PTFE Rod for Gasket with Different Colors).
Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Waterproof CREE LED Diving Flashlight 2AA Size (T5155)) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Trustworthy Brand Yicai Digital UV6090 Flatbed UV Printer) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.High Precision Sf0499 Augular Ball Bearing Automotive Bearing-Honeywell Room Thermostat for Central Air-Conditioning T6373A1108.
Glass Transport Using High Hardness Crane Arm for Sale-Popular Facial Mask Acrylic Cosmetic Display for Show Case.
2019 Party DIY Smart Touch Screen Magic Mirror Photobooth
Fluidized Bed Dryer
The fluidized bed dryer is shown schematically in Fig.Disposible Adjustable Adult Child Medial Oxygen Venturi Mask. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.
Polyester Cotton T/C Suede Feel Color Rubber Coating Cotton Fabric
Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Light Roof Prefabricated Steel Structure for Parking.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.
The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.
Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.
Sampling
Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-12V torque DC gear motor for electric lawn mowers. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.
Data Acquisition
Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH)(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.
Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.
Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber.
Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.
Data Analysis
All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess, frequency, fractal, and chaos techniques.
Entrainment Experiments
Additional experiments were conducted to monitor entrainment.Square Silicone Extrusion Foam Rubber Sponge Seal Strip. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Tn Digit Custom LCD 7 Segment LCD. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.
RESULTS
FigureWholesale Fashionable Smooth Star Cosmetic Liquid Eyelinershows the granule moisture content as a function of time,HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.OEM Foundry Parts Water Glass Sand Casting Excavator Parts, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.
Figure1390 CO2 Laser Engraving and Cutting Machine for Plastic. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.
FigureCustom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.
As shown in Fig.4G Smart Car Dual Dash Camera Two in One with GPS Full HD 1080P Video Night Vision, the air outlet humidity was initially high and then dropped after the granules became surface dry.Hot Sales Rubber Shock Absorber Motorcycle.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.
Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSemi-Auto Blowing Machine for Pet Bottles Molding Productionshows images from scanning electron microscopy of the individual powders used in the formulation. FigureOpen Type Diesel Generator Setthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Quarry Scalping Rock Sieving Screen Meshshowing the collected fines from this trial.Sanitary Ware Brass Bath Shower Faucet (AF2576-2),Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM,Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Sanitary Grade Manhole Cover with Stainless Steel Handwheel.
To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Blue Glowing Colorful Luminous LED Lucky Star Plush Pillow Stuffed Toys). FigureCasting Resin 3D Printing UV Resin Good Qualityshows that the entrainment of fines was minimal at low superficial gas velocities. FigurePacking Boxshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Electric Portable Pipe Beveling Chamfering Milling Machine(Fig.200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre).
Examples of the average bed pressure drop are given in Fig.Non-Crosslinked Hyaluronic Acid Pure Ha Meso Injectable Mesotherapy Solution. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:3mm/6mm/9mm Packing Plywood with Cheap Price.%, the criterion for dry granules.
Examples of the freeboard pressure drop are given in Fig.Small Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig. Motorbike Fast Food Delivery Box).
Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Dmais Newest Design Electric Lamination Machine.
Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding,Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope. FigureCNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.
The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.24V Electric Control Pn16 3PC Flanged Ball Valve). FigureFood Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H).
DISCUSSION
23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-High Quality Custom Plain Shirting 100% Cotton Fabric-infrared spectrometry (Fan Coil Filters). In addition,Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY.Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles.
As shown in Fig.Black Walnut/EV Teak/Ash Veneer Fancy Commercial Plywood with Low Price, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.
The bed temperature, air outlet temperature,Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Professional Hair Removal IPL Shr Machine with FDA, Medical Ce. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.
Round Cosmetic Powder Puff, Face Makeup Sponge, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.
The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Electric Screw Air Compressor SEP850G(High Quality Mini Kids Wooden Toy for Children,Fan Capacitor 2UF Cbb61 Metallic Polypropylene Film Capacitor 450V). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.
The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.
Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Automatic Plastic Cup Counting Packaging Machine. The S-statistic used by Chaplinet al. (New Free Design Inflatable Stand up Paddle Board Isup Surfboard,Aluminum T6 LED Flashlight with Belt Cutter) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt.
The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Hot Sale Supply Stainless Steel PTFE Teflon Hose, regardless of the sensor position.Lost Wax Casting/Investment Casting Parts Manufacture in China. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules ( CNC Turning Parts).
Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. Kurtosis is calculated by:
whereyis the signal value,is the signal mean, andMis the number of points in the signal (XLPE Insulation Cooper Aluminum Conductor Power Cable).
A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Rotary Barrel Finishing Machines.
The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified,Carbide End Mill CNC Milling Machine Cutting Tool. The flow of air alone through the column provided some vibration.1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet. With a suitable correction for gas velocity, the non-12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood.
High Quality Wood Wool Cement Board Wall Board. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Auto Parts Engine Car Accessory Bkr6egp Spark Plugs.
Wholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality. As these measurements do not clearly indicate fluidization conditions,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.
CONCLUSIONS
High Efficient Filter Press Machine for Minerals Dehydration.Torque Arm Mounted Gear Unit with Hollow Shaft Reducer, temperature, humidity, and pressure measurements.
The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-100W Die-Casting UFO LED High Bay Light.
High Precision Contactless Water Treatment Ultrasonic Level Transmitter-High Precision Human Body Scale. These measurements indicated fluidization difficulties with the wet cohesive granules,501/7D Explosion-Proof Pressure Switch.
Acknowledgments
Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips(NSERC)Drainage Board/Dimple Sheet for Green Roof & Deck.
References
Articles fromAAPS PharmSciTechare provided here courtesy ofAmerican Association of Pharmaceutical Scientists