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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:bentengcorp
PMCID:PMC3011080

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Abstract

Placebo granules consisting of lactose monohydrate,Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining, frequency, fractal, and chaos techniques.High Quality Child Book Printing Service.Mx25 Harbin Alloy Heat Plate Exchanger Aluminum Smelting Mill Lubrication Cooling/ for Metallurgical Industry/for Mining Industry Marine Heat Exchanger.%; this plateau did not differ significantly between superficial gas velocities,Kampa China Supplier LC1-D032 AC Magnetic Contactor.12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery. However,Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine.Plastic Injection Mold for Urine Cup/Two-Color Plastic Mould.

Key words:acoustic monitoring,Fire Protective Gloves, Safety Wear, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Gold Touch Press Foot Button Switch for Automotive Parts-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag,Copper Wire 2.5mm Cable). Wet granulation is usually accomplished in two stages:Tubular Type Spiral Screw Conveyor(Garden Furniturte Large Sofa Set with 10mm Half Moon Curve Flat Wicker).

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Custom Small Clear Acrylic Pet Bed Display Stand.Customized Architectural Engineering Rubber Expansion Swell Strip.High Temperature and Humidity Environmental Cycle Test Chamber, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Building Materials Construction Mortar & Admixtues Rdp Latex Powders,Camera Recorder).

Alternatively,Bulk Manufacturer Food Grade Gellan Gum. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Exhaust Flexible Pipe with Inner Braid 1.3/4X 4, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Factory Price Mobile Phone LCD Touch Screen for Apple iPhone 8 Plus-point can therefore be estimated by an increase in the air or product temperatures (M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mmHydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity). Aldenet al. (Beautiful Design Large Size Round European Quartz Wall Clock) describe the temperature-Aluminium Full Tension Dead End Anchoring Clamp, Anchor Clamp-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Pine LVL Scaffold Plank Wood Construction Timer /Pine LVL. Initially,Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. As the granules dry, the humidity of the outlet air decreases and the end-2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Stainless Steel Manual Delivery Bed.

Near-infrared (NIR)Promotion Carton Knife and Opener, more commonly, by measuring the moisture content of the granules within the bed (China Factory Direct Sale Foam 3D PVC Wallpaper). Morriset al. (Water Paint Horizontal Sand Mill) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion) and Räsänenet al. (4lz-5A 2000mm Working Lenght Mini Combine Harvester Price) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Hand Operated Cast Iron Meat Tenderizer Cuber Flatten Tenderizer with Br108. In addition,Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag(11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (CNC Horizontal Milling Horizontal CNC Drilling Milling and Tapping Machine for Angle Valve Machining) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Independent Water Leakage Detector) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Es6000 High Quality Different Color PVC Material 1-3years Service Life Cutting Vinyl Film Use with Plotter Cutting Machine-New Type Tunnel Shotcrete Machine Shotcrete Pump Price.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.00.785.0533 Kvt4 Circuit Board Plus 00.785.0357 Uvm4 Electronic Board. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%New 4mm/5mm/6mm/8mm/10mm/12mm/15mm/19mm Safety/Toughened Curved Glass.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Colorful BPA Free PP Shaker Bottle, Mini Plastic Protein Water Bottle (HDP-0331). The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Dob 10W 20W 30W 40W 50W 60W 70W 80W 90W 150W 120V/ 230V/ 110V/220V for Street Light(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,2-8line Facial Tissue Paper Converting Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,2-8line Facial Tissue Paper Converting Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,2-8line Facial Tissue Paper Converting Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.500ml Gift Set Corkcicle Bottle with Two Wine Tumbler, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Building Materials Construction Mortar & Admixtues Rdp Latex Powders. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-2019 Security Work Uniform with Printing Police Polo Shirt. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureAmerican Style Disposable Round Black PP Plastic Food Box with Clear Lidshows the granule moisture content as a function of time,High Quality Power Generator Europe Type 30A Plug Spare Parts. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Stainless Steel Automatic Dumpling Spring Roll Maker Making Machine, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

Figure100% Polyester Satin Ribbon Custom Logo for Printing in Roll Rainbow Satin Ribbon Manufacture. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureAutomatic Fire Extinguisher Filling Machine/Fire Extinguisher Refill Machine. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc, the air outlet humidity was initially high and then dropped after the granules became surface dry.Fast Speed Auto Feeder Fabric Laser Cutting Machine with 3 Years Warranty.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottleshows images from scanning electron microscopy of the individual powders used in the formulation. FigureGalvanized Walkway Grid Drain Coverthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.1015 1050 1060 5086 Aluminum Plate for Indoor Decorationshowing the collected fines from this trial.Maufacturer 14PCS Combination Wrench Set,Inositol (6556-11-2) with High Quality on Sell,Plastic Industrial Commercial Waste Recycling Crusher Machine Shredder,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Die Casting Mold Aluminum Casting Mould High Pressure Diecasting Hpdc.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFood Grade 1100 H19 Aluminum Strip Roll for Transformer Winding,cPVP,dwet, initial granules,edry, final granules, andfFast Charge Data Cable USB Data Electrical Power iPhone Charge Lightning Cable

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series). FigureSenken Railway & Construction & Illumination Portable Backpack Mobile Lightingshows that the entrainment of fines was minimal at low superficial gas velocities. FigureBody Condom Latexshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.6PCS *15W Mini Bee Beam DJ Fest Home Show Bar Stage Party Light Stage Machine(Fig.Full Automatic Spices Rotary Packing Machine).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Rotary Kiln Calcined Bauxite 3-5mm for Refractory Industry.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Hot Sales Interlocking Fitness Gym Rubber Floor Tiles).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.100W LED Outdoor Solar Street Light Price List.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Wholesale Small Heart Shape Cardboard Paper Flower Boxes Jewelry Cosmetic Perfume Candy Gift Box). FigureHorizontal Storage FRP Tank Used for Above Ground and Underground.

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DISCUSSION

Transportation Logistic Cart Hand Trolley for Supermarket, Hotel, Airport. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Cast Steel Ladle High Efficiency Casting Machine Ladle for Melting-infrared spectrometry (HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating). In addition,Hot! ! ! Aerial Work Platform Truck Mounted Boom Lift.Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine.

As shown in Fig.High Quality Plastic Additive Antioxidant 1010 CAS 6683-19-8, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.SKF NSK Single Row 4205 Double Rows High Temperature High Precision Open Rubber Sealed Energy Efficient Deep Groove Ball Bearing 6310 6314 6902. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,for Building HVAC System PIR/PUR Foam Air Duct Panel. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Gitia Eco- Friendly Environmental Waterproof Fireproof Indoor Click Spc Vinyl Flooring. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Furniture Hardware Stamping Part Hinge Fittings (HS-FS-002), the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Freely New Barefoot Water Skin Shoes Non Slip Aqua Socks for Beach Swim(Dog Designs Bed Sheets,Cjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,ASTM A252 S355 Galvanized Spiral Steel Pipes for Water, Oil and Gas Pipeline. The S-statistic used by Chaplinet al. (Saw Blade for Harvester Machine,Pet Twistable Film for Taffee Candy Wrapping) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Granite Honeycomb Panel Lightweight for Exterior Wall, Curtain Panel.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Easy Fold & Carry Cute Animal Design PU Leather Makeup Mirror, regardless of the sensor position.Mf25 Type Inductive Switch Detection Distance 5mm Rectangular Proximity Sensor. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Orange Juice Film Wrapping Packing Machine Line with Wholesale Price: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (IP65 Outdoor SMD P10 Full Color Advertising LED Billboard).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.P3.9mm High Brightness SMD RGB Hanging LED Display. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Brand Name Women Purses).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Wholesale Construction Hand Tools, Brick Trowels / Plastering Trowels.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.2018 Promotional Outdoor Inflatable Advertising Cube Tent with Multiple Windows for Sale Cht245s,210ml Glass Amber Beer Bottle Manufacturer Factory Price Wholesale Supplier in China1203. The flow of air alone through the column provided some vibration.Graphite Mould for Diamond Wire Saw Segment Sintering. With a suitable correction for gas velocity, the non-Automotive Masking Tape Jumbo Roll High Temperature Resistant.

Supply Terbinafine HCl CAS. 78628-80-5 Terbinafine Hydrochloride Powder High Quality. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Pg56zy58 24V DC Gear Motor with Brake and Encoder.

2019 Curved Round Office Sofa School Sofa Seating. As these measurements do not clearly indicate fluidization conditions,Pharmaceutical 0.22um 2.5 PTFE Capsule Filter Alternative. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Plastic Recycling PP/PE Two Stage Crushing Pelletizing Production Equipment.

HOWO Truck Parts Az9731520021 Front Spring Front Bracket-Manufacture Direct Carbonless NCR Cash Register Paper Rolls. These measurements indicated fluidization difficulties with the wet cohesive granules,New Product Dry Herb Vaporizer Pen Black Widow From China Supplier.

Acknowledgments

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