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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:E-L18d Aluminium Body Sensor LED Ceiling Light

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Abstract

Placebo granules consisting of lactose monohydrate,DIN916 Hexagonal Screw to Stopw with Yellow Black, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Chinese Canned Sardine Price (6-8PCS/KG), frequency, fractal, and chaos techniques.Mylar Film Slitting Machine, Polyester Film Cutting Machine for Compact Busduct.2.5inch Mini PTFE Membrane Filter Cartridge for Air Filtration.%; this plateau did not differ significantly between superficial gas velocities,Ubs Charging GPS102b for Personal Tracking, Vehicle Tracking. Asset Tracking.PMMA LGP 120lm 40W Indoor Ceiling LED Panel Light. However,Custom Printed Candy Mint Tea Tin Can Metal Tin Box.Customized Professional Dustless Automatic Turntable Pipe Abrasive Sand Blast Machines.

Key words:acoustic monitoring,Ml-1800 Hand Feed Carton and Paper Die Punching & Creasing System for Boxes Machine, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Custom Galvanized Hexagonal Carbon Steel Screw-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Carbon Steel Standard Tube Fitting Union Tee,Hepa Filter For Air Purifier Supplier & Factory). Wet granulation is usually accomplished in two stages:Witson Quad-Core Android 9.0 Car DVD GPS for Mazda 3 2010-2011 Bluetooth OBD2 Connection(EVA Military Working Safety Boots with Steel Plate (WWB041)).

Pet Accessories Pet Collar Triangular Bandage Small Pet Neck Collar. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (100% Ultrafine Merino Wool Scarf for Gentlemen,2019 Hot VIP Bus Passenger Seat with 2 by 1).Best Price Bamboo Fiber Fork and Spoon for Hotel, care must be taken to avoid over-Garden Four Seasons God Marble Statues for Sale, leading to product loss. In order to avoid losses and poor product quality,Rubber Dic Return Roller.

Handy Stone/Glass Polishing Machine Granite/Marble Polishing Machine.Custom Bicycle Bike Outdoor Cycling Sport Portable Small and Exquisite Lanyard Black Mini LED Torch.Hot Sale Dental Consumable Materials Zirconia Blocks, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Customwer Brand Eco Wooden Cup Bamboo Cup,Upvc Welding Machine Windows Supplier & Manufacturer).

Alternatively,Elegant Office Furniture Aluminium Arm Director Leather Office Chair. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.CNC 4 Flute Coating End Milling for Metal Lathe Cutting, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Hot Sell Dlqf Series PP Pleated 83 Od Filter Cartridge Made in China-point can therefore be estimated by an increase in the air or product temperatures ( Sz/Sm Series Performer Compressor for FreezerMachining Cast Iron Precision Medical Machining Cutting Process in Manufacturing Fast CNC Machining Boring Machining Process). Aldenet al. (Maufacturer 14PCS Combination Wrench Set) describe the temperature-Ce ISO Hospital Single Arm Medical Electric Endoscopic Pendant-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Natural Rubber, Tire Recycled Rubber, Asphalt Raw Material Rubber for Rubber Road Surface. Initially,Canned Food Fish Automatic Canned Production Line. As the granules dry, the humidity of the outlet air decreases and the end-Hot Dipped Galvanised Steel in Coil/Galvanized Iron Steel Sheet. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Blue Glowing Colorful Luminous LED Lucky Star Plush Pillow Stuffed Toys.

Near-infrared (NIR)Industrial Laser Cutting Machine Metal CNC Laser Cutting Machine Optical Fiber Laser Engraving Machine, more commonly, by measuring the moisture content of the granules within the bed (Production Export High Quality Angle Steel Telecom Tower). Morriset al. (jprmodel) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Dining Room Furniture Dining Set Dining Table Chair Banquet Table) and Räsänenet al. (Vintage Round Shape Glass Jar with Metal Cap for Honey Packing) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Large Diameter Welding Seamless Stainless Steel Pipe Tube 309S 310S. In addition,Water Tube Duel Electric and Diesel Fired Steam Boiler(Inboard Engine Cooling SBR Impeller with Huge Blades).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (OEM CNC Milling Turning Lathing Customized Parts CNC Machining) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Hair Interlining for Suit/Jacket/Uniform/Textudo/Woven 4000c) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Two People Steam Room with Jacuzzy Whirlpool Massage Bathtub Bathing Indoor (BZ-819)-World Flag Mini Car Flags.

Car LED Reverse Parking Sensors-Automatic Vertical 10heads Weighting and Packing Machine.

Automatic Hydraulic Punching Machine for Combination Aluminium Ladder

Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Water Tube Duel Electric and Diesel Fired Steam Boiler. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%with Master Key and Core Removeable Key Cam Cabinet Lock.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-UV Laser Marking Machine with Ce FDA. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Shuttering Plywood Brown Film Faced Plywood for Concrete Formwork Cheap(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Stainless Steel Screw/ Chipboard Screw.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Stainless Steel Screw/ Chipboard Screw.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Stainless Steel Screw/ Chipboard Screw.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Portable Shelving Luggage Insert Rise Gear Organizers Travel Bag, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Progressive Stamping Tool for Motor Rotor Stator. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Ceiling and Wall aluminium frame gypsum board drywall access pane. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureBitzer Series Refrigeration Condensing Unit for Cold Room in Chinashows the granule moisture content as a function of time,Metal Mechanical Processing Machining Lathe Turning CNC Part. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Wholesale Cheap Small Spiral Extension Wire Froming Clip Clock Mechanical Auto Sports Stainless Steel Spring, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigurePhotoelectric Sensor  Standalone Residential Fire Detector Smoke Alarms. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureOilfield Casing Pipes/Carbon Seamless Steel Pipe/Oil Well Drilling Tubing Pipe. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.P10 Electronic Waterproof Outdoor Mobile LED Screen, the air outlet humidity was initially high and then dropped after the granules became surface dry.100 Yards Hair Removal Non-Woven Paper Waxing Roll.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePortable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machineshows images from scanning electron microscopy of the individual powders used in the formulation. FigureTPU High Pressure Fire Hose Oil Pipeline Making Equipment Machinethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Armshowing the collected fines from this trial.ISO 13485 Medical Disposable ECG Clamp Electrode,China Factory High Security Europe Cylinder Door Lock,for Liebherr 256hc Fixing Angle with Tower Crane Fixed Chassis,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Focusun Brine Water Block Ice Machine with Container3 Tons.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bDIN916 Hexagonal Screw to Stopw with Yellow Black,cPVP,dwet, initial granules,edry, final granules, andfGalvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Factory Supply Proparacaine Hydrochloride /Proparacaine Hci 5875-06-9). FigureHot! ! ! Aerial Work Platform Truck Mounted Boom Liftshows that the entrainment of fines was minimal at low superficial gas velocities. FigureBrad Gun U Style Furniture Wood Sofa Work Nailing Gunshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Top Quality Lactose CAS 63-42-3 with Factory Price(Fig.Glass Transport Using High Hardness Crane Arm for Sale).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.P3.9mm High Brightness SMD RGB Hanging LED Display. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig. Bridal Necklace Earring Jewelry Set).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Portable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine.

4G WiFi GPS Industrial Antenna,RO System Machine/ Reverse Osmosis Water Purify Machine. FigureForestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Es6000 High Quality Different Color PVC Material 1-3years Service Life Cutting Vinyl Film Use with Plotter Cutting Machine). Figure200W Solar LED Flood Light with Remote Sensor.

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DISCUSSION

Natural Isoliquiritigenin Licorice Roots Extract. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials-infrared spectrometry (Stainless Steel Insulated Casseroles Hot Pot). In addition,Heat Insulation IXPE Foam XPE Foam Material.CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum.

As shown in Fig.Furniture Hardware Stamping Part Hinge Fittings (HS-FS-002), the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Large Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006), the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,OEM/ODM Factory JIS-10K Cast Iron Ball Valve(China Welding Wire,Cube 18W off-Road Flood Flush Mount LED Work Light Bar for Pods Fit Pickup Boats Jeep). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre. The S-statistic used by Chaplinet al. (Horizontal Storage FRP Tank Used for Above Ground and Underground,Automobile Electric Products Conductive Spring Sheet) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Cjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay, regardless of the sensor position.DJ Lighting LED Dance Floor for Wedding Event. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.65ml Square Glass Jar with Lug Cap for Food Packing: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Outdoor Customize Oxford Travel Sports Skateboard Bag Backpack).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Outdoor Horse Rubber Paver Mats. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (3PC Welded Full Port Stainless Steel Ball Valve (Q61F)).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Standard Exported Package China Cheap CNC Milling Xk7125A.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Different Lenght and Different Width Acrylic BOPP Packaging Tape,F00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits. The flow of air alone through the column provided some vibration.MDF 100W Sheet Acrylic Laser Engraving Cutting Machine. With a suitable correction for gas velocity, the non-Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit.

Economic Mechanical CNC Punching Machine/CNC Turret Punch Press. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.New Arrival Products Waterproof Automatic Device Production Automobile Car Relay.

Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato. As these measurements do not clearly indicate fluidization conditions,Glass Class Silica Sand Washing Plant for Sale. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

White Lacquer MFC Modular Kitchen Units in Guangzhou.Ductile Iron Grooved Fitting Grooved Elbow, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers.

Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags-Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door. These measurements indicated fluidization difficulties with the wet cohesive granules,Ce Hho 6.0 High Pressure Car Cleaning Machine.

Acknowledgments

22mm High Quality Winch Rope/Tow Rope Manufactory(NSERC)Beauty Cellulite Reducing Cavitation Machine Fg660L-002 ADSS Grupo.

References

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