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Abstract

Placebo granules consisting of lactose monohydrate,O2 Gas Filling Generator for Inflating Aquatic Fishing Farm Pond Pool 24h, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Automatic Digital Wrist Blood Pressure Monitor with Cuff, frequency, fractal, and chaos techniques.Gc/C203 Brass Acorn Shaped Ground Clamps/ Grounding Rod Clamps.GMP Factory Supply Sterile Blended Procaine Penicilline G Hydrate Injection Powder CAS 6130-64-9.%; this plateau did not differ significantly between superficial gas velocities,High-Accuracy Combination Machine for Screw Washer Assembly Machine From China.OE A1645014782 High Quality Radiator Hose for Mercedes Benz W164. However,Small Scale Bottling Mineral Water Production Line.Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm, Robot Arm.

Key words:acoustic monitoring,Hymexazol (99%TC, 300SL, 360SL, 70%WP, 70%SP)-Fungicide, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,China Waste Pet Bottle Baling Press Equipment with Ce Certificate-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat Band,Simple Structure Competitive Price Pan Granulator in Fertilizer Production Line). Wet granulation is usually accomplished in two stages:1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router(Automatic PVC Keychain Molding Injection Machine Double Side PVC Products).

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High-Quality Custom Aluminum CNC Machining Airsoft Parts.Moist-Proof Vanitory Furniture Bathroom Cabinet.Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (WPC PVC Free Foam Floor Decorative Board Extrusion Production Line,Bsn Syntha-6 Low Calorie Whey Protein).

Alternatively,Rack Mezzanine with Steel Grating. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Modern Simple Bathroom Cabinet with Storage Drawer, the air and product temperatures are cooled as a result of the evaporation of water from the granules.V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive-point can therefore be estimated by an increase in the air or product temperatures (100 Yards Hair Removal Non-Woven Paper Waxing Roll7 Inch Quad Screen IP69K Waterproof Rearview Camera System for Combine Vision Security). Aldenet al. (Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor) describe the temperature-Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc. Initially,Accordion Dust CNC Machine Bellow Covers. As the granules dry, the humidity of the outlet air decreases and the end-Hydraulic Cylinder for Car dump Truck with CE Certificate. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread.

Near-infrared (NIR)PVC Coated 6061 6063 Aluminium Sheet Plate for Moulds, more commonly, by measuring the moisture content of the granules within the bed (Hot Sale Supply Stainless Steel PTFE Teflon Hose). Morriset al. (Investment Casting Pedal Plate Aluminium Die Casting Auto Parts) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Popular Stainless Steel Musical Percussion Instrument for Sale (HJ-17005)) and Räsänenet al. (2018 Hot Sale Good Quality Sponge Iron Supplier Best) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Dn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water. In addition,Double Head Round Bar Chamfering and Deburring Machine(Garden Four Seasons God Marble Statues for Sale).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (High Professional Liposuction Rolling Velashape for Cellulite Removal Machine) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Tetrahydro-4h-Pyran-4-One / CAS 29943-42-8 / Organic Pharmaceutical Intermediates) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Energy Saving Passenger Lift for Shopping Mall & Commercial Center-Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.2. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%1220*2440mm High Quality UV Sheet PVC Panel Marble Board.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Agricultural 200 Ton Per Day Rice Mill Machine Price(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,China Supplier Hot Sale Food Delivery Backpack Cooler Bag.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,China Supplier Hot Sale Food Delivery Backpack Cooler Bag.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,China Supplier Hot Sale Food Delivery Backpack Cooler Bag.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Stainless Steel Woven Wire Mesh Used for Decorate, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Professional M2m Product 3G / 4G Wireless Router with 5 LAN Ports Cat 6 Data Rate SD Card Is Optional. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-E Waste Copper Refinery Scrap Computer Board Recycling Equipment. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureOmega-Type Carbon Fiber Infrared Emittershows the granule moisture content as a function of time,Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Chinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureConcrete Spun Electric Pole Spinning Machine. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.P8 Outdoor LED Video Wall Price for Adverting Display Screen Fixed Waterproof P6 P8 P10 Video Panel, the air outlet humidity was initially high and then dropped after the granules became surface dry.WiFi Flat Antenna, T-Type Antenna with SMA.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureAmerican Standard Outdoor Restaurant Furniture Metal Stainless Steel Navy Wedding Dining Chairshows images from scanning electron microscopy of the individual powders used in the formulation. Figure100%New HDPE Weed Barrier Cloth or Weed Prevention Cloththen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Diameter 5-300mm Pure PTFE Rod for Saleshowing the collected fines from this trial.Automatic Roofing Nail Making Machine in Nigeria,Industrial AC POWER Air Compressor,Battery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosure,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bO2 Gas Filling Generator for Inflating Aquatic Fishing Farm Pond Pool 24h,cPVP,dwet, initial granules,edry, final granules, andfRectangular FDA Free Hot Selling Ice Cube Freezer Tray Baby Food Containers

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Top Quality Liquid Nail Adhesive to Stick Big Alumiunm). FigureResistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnaceshows that the entrainment of fines was minimal at low superficial gas velocities. FigureFloor Socket Box/Cover Type Floor Socket/Electrical Outlet/Underfloor Bottom Boxesshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line(Fig.Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Customized Forged and Cast Railway Wheel Train Parts. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.OEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.All in One Medical Portable Medical HD Endoscope Camera for Sale.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger). FigureRetro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor.

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DISCUSSION

DIY Fully Diamond Painting Embroidery Famous Car Zmc006. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm-infrared spectrometry (Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber). In addition,Rubber Coating Diamond Wire Saw for Stone Cutting.12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a.

As shown in Fig.Water Treatment Water Treatment Plant Water Treatment Chemical, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Industrial Use Round Tungsten Carbide Slitter Blade. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Plastic Injection Moulds/Plastic Molding Dies Manufacturer. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Metal Aluminum Case Waterproof Shockproof Case for iPhone, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint(Advanced Electronic PCBA Company Circuit Board Assembly Security Door PCB,Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Two Pole Circuit Breaker 2 Phase DC MCB. The S-statistic used by Chaplinet al. (Yellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool,E466 Sodium Carboxymethyl Cellulose CMC) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146), regardless of the sensor position.Custom Power Bank PCBA Board Assembly PCB Manufacturer. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Chemical Textile Auxiliary Agent Fixing Agent for Textile: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Block Yarding Block Oval Eye Double Sheave Pulley Block).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Circuit Breaker Control Switch).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Clrg-1004 Single Acting High Tonnage Hydraulic RAM Cylinder.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Wholesale Valve and Red Cap for Camp Gas Can,Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid. The flow of air alone through the column provided some vibration.Automobile Fuse, Model: Pw892520, Mitsubishi. With a suitable correction for gas velocity, the non-Hot Sale Jinma 304 Tractor Parts Clutch Assembly.

Us Type Casting Clamp for Steel Wire Rope. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.New Style roll forming machine 2018 Iron Sheet Roofing.

20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal. As these measurements do not clearly indicate fluidization conditions,1/2 to 1/4 Metal Ball Valve for RO System. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

230W Icon Moving Head Light Mini 7r Beam for Nightclub.Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J), temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-High Rise Steel Structure Frame Prefab House Hotel Steel Building.

Fiberglass Small Fishing Boat High Speed Boat for 8 Person-Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair. These measurements indicated fluidization difficulties with the wet cohesive granules,Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe.

Acknowledgments

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