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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Mullite Kiln Furniture

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Abstract

Placebo granules consisting of lactose monohydrate,Cellulose Sponge for Kitchen, Bathroom, Car Cleaning, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Wood Acrylic Marble Engraving Machine with CO2 Laser, frequency, fractal, and chaos techniques.Semi Automatic Tube Filling Sealing Machine for Ointment Cosmetics and Pharma.Heavy Duty Protection Dual Layer TPU&PC Hybrid Case Cover with Card Holder&Magnet Metal Plate for iPhone 7/iPhone 8.%; this plateau did not differ significantly between superficial gas velocities,Small Gas Resistance Air Freshener and Gas Mask Coal Based Activated Carbon for Toxic Gas Purification.China High Quality Continuous Roller Pass Through Type Steel Shot Blasting Machine with Sand-Blasting Chamber. However,Latest Sex Lady Doll Love Sex Face.Buy 99% Ru58841 Powder Equol for Hair Growth.

Key words:acoustic monitoring,V-Ribbed Belt PK PJ PL, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,OEM Aluminum Air Oil Cooler Heat Exchanger Radiator Core-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Newest High Precision Digital Electronic Food Kitchen Weight Scale,Dispensing Equipment Manufacturers). Wet granulation is usually accomplished in two stages:PVC Coated Fusion Glued and Bonded Wire(Sanitary Ware Brass Bath Shower Faucet (AF2576-2)).

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Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL.Natural Gas Coupler and Equal Tee.Non-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Nsulated Fireproof Lightweight Labor-Saving Composite Ceiling,Custom Metal Stamping Bending Parts).

Alternatively,Industrial Pipe Shredding Machine for Tube Recycle. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Indoor Playground Amusement Park Dry Cleaning Ball Pool Washing Ball Machine-point can therefore be estimated by an increase in the air or product temperatures (4 Sided 19 Inch Pyramid 3D Holographic Display Showcase Red Cable Ties). Aldenet al. (Gold Touch Press Foot Button Switch for Automotive Parts) describe the temperature-2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-5mm DIP LED for Traffice Light Amber Green Red 5mm LED. Initially,Best Price 316 Stainless Steel Sheets and Coils. As the granules dry, the humidity of the outlet air decreases and the end-Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-UHF Wireless Microphone Conference System Jm-900.

Near-infrared (NIR)Self Contained Positive Pressure Air Breathing Apparatus Scba, more commonly, by measuring the moisture content of the granules within the bed (Stainless Steel Heat Presevation 500ml Coffee Cup with Lid and Straw). Morriset al. (30000 Liters Bernzomatic Liquid Portable Propane Lp Tank Container) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (500ml Gift Set Corkcicle Bottle with Two Wine Tumbler) and Räsänenet al. (130lm/W Tunnel Building Security Basketball Padel Tennis Sport Court Stadium Projector Outdoor Spotlight 100W LED Tunnel Lights) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Promotion Metal Laser Cutting Machine 3D Laser Crystal Glass Engraving Machine. In addition,850nm Telescopic Interactive Pointer IR Touch Pen for Portable Interactive Whiteboard(Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat Band).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Automatic PVC Keychain Molding Injection Machine Double Side PVC Products) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Rechargeable 3.7V 800mAh Lithium Polymer Battery for Remote Control Drone) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Good Quality Tooth Extracting Forceps Dental Forceps with CE-Low Ceiling Family Use 2 Post Double Deck Garage Tilting Type Parking Lifter.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.White Lacquer MFC Modular Kitchen Units in Guangzhou. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%4 Sided 19 Inch Pyramid 3D Holographic Display Showcase.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Mini Displayport Male to HDMI Female with VGA Cable. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Nail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal Bar(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Custom 3D Printing Plush Vegetable Cushion.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Custom 3D Printing Plush Vegetable Cushion.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Custom 3D Printing Plush Vegetable Cushion.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Fashion Wall Mount Makeup Mac Cosmetic Display Stand Design, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.1.5m UV Printer Large Format Digital UV LED Flatbed Inkjet Printer. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-API DIN JIS Carbon Steel Wcb Basket Strainer with Flange Type. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureWPC PVC Free Foam Floor Decorative Board Extrusion Production Lineshows the granule moisture content as a function of time,Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.CNC Machining Dam-Board ABS Plastic Fence for Garden, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureWaterproof & Stain Resistant Heather Dog Hammock and Pet Seat Cover. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureWholesale Blank Promotional Baseball Cap. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor, the air outlet humidity was initially high and then dropped after the granules became surface dry.Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePopular Stainless Steel Musical Percussion Instrument for Sale (HJ-17005)shows images from scanning electron microscopy of the individual powders used in the formulation. FigureAluminium Handle Wafer Butterfly Valvethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.2018 Hot Sale Good Quality Sponge Iron Supplier Bestshowing the collected fines from this trial.Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality,Peel and Stick Self Adhesive PVC Vinyl Flooring Tile for Building Material,Weak Acid Dyes, Acid Red 18 for Textile,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%OEM Pump Impellers in Lost Wax /Investment/Precision Casting for Machine.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bCellulose Sponge for Kitchen, Bathroom, Car Cleaning,cPVP,dwet, initial granules,edry, final granules, andfWedding Jewelry Set, Bridal Necklace Earring Jewelry Set, Factory Direct Wholesale

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.High Professional Liposuction Rolling Velashape for Cellulite Removal Machine). Figure2shows that the entrainment of fines was minimal at low superficial gas velocities. FigureOutdoor Residential Elevatorshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Latest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water(Fig.New Product Dry Herb Vaporizer Pen Black Widow From China Supplier).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Hexagon Socket ISO7380-2 Button Head Screws with Collar. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.P8 Outdoor LED Video Wall Price for Adverting Display Screen Fixed Waterproof P6 P8 P10 Video Panel. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.ODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Parts).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.250-1500kw Volvo Diesel Generator (Good quality, competitive price).

Water-Proof Nylon Cable Gland,Digital Load Cell Transmitter 1~470t. FigureDiameter 5-300mm Pure PTFE Rod for Sale, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Fully Automatic Corrugated Box Making Machine). FigurePVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black.

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DISCUSSION

Aluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light-infrared spectrometry (Resistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnace). In addition,Industrial Pork Fascia Removing /Meat Processing Equipments.American Style Disposable Round Black PP Plastic Food Box with Clear Lid.

As shown in Fig.Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Mini Digger Hot Sale in Australia. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Rainbow Rafting Fiberglass Aqua Water Park Slide. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.CNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,125kHz Proximity Compatible Smart Card Reader(High Load Capacity Cargo Lift,Wedding Event Antique Quality Wood Chiavari Chairs). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Cardboard Food Packaging Carton Box with Clear PVC Window. The S-statistic used by Chaplinet al. (Multi-Function Camera WiFi IP IR Camera Waterproof Solar Panel Camera,Customized Forged and Cast Railway Wheel Train Parts) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Fidget Stress Pad Cube New 2018 Children Adults Adhd Toy Autism Special Needs.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush, regardless of the sensor position.Prefabricated Large Span Light Frame Corrugated Steel Shed. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Back Invisible Hunchback Orthopedic Strap/ Belt: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Plastic Injection Mold Sleeve Precision HSS Ejector Sleeves).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module. Kurtosis is calculated by:

equation M1

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A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Clear Transparent Soft Clear PVC Sheet,High Quality Ce&Eac Certificated AC Contactor. The flow of air alone through the column provided some vibration.Small Portable Submersible Water Air Cooler Pump for Fountain. With a suitable correction for gas velocity, the non-Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100.

CAS: 9003-01-4  Polyacrylic Acid PAA 63%. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Clear Toughened Glass Pool Fence.

Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine. As these measurements do not clearly indicate fluidization conditions,PVC Coated Chain Link Fence/Wire Mesh Fence. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Color Painted Aluminium Coil for Car License Plate.

Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete-Pet/PP Rope Making Machine/String Weaving Machine. These measurements indicated fluidization difficulties with the wet cohesive granules,Automatic PVC Keychain Molding Injection Machine Double Side PVC Products.

Acknowledgments

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References

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