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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:High Quality PETG Transparent Plastic Film Sheet

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Abstract

Placebo granules consisting of lactose monohydrate,Non-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Industrial Pipe Shredding Machine for Tube Recycle, frequency, fractal, and chaos techniques.Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor.Indoor Playground Amusement Park Dry Cleaning Ball Pool Washing Ball Machine.%; this plateau did not differ significantly between superficial gas velocities,2019 Best Aluminum Housing Hanging Hydroponic LED Grow Light.5mm DIP LED for Traffice Light Amber Green Red 5mm LED. However,Best Price 316 Stainless Steel Sheets and Coils.Five Arms Used Zoomlion Qy50V 50 Ton Mobile Truck Crane.

Key words:acoustic monitoring,UHF Wireless Microphone Conference System Jm-900, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Self Contained Positive Pressure Air Breathing Apparatus Scba-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Stainless Steel Automatic Dumpling Spring Roll Maker Making Machine,High Temperature Heat Resistance Teflon PTFE Self Adhesive Heating Tape). Wet granulation is usually accomplished in two stages:Promotion Metal Laser Cutting Machine 3D Laser Crystal Glass Engraving Machine(School Uniform Trousers Boys Sports Trousers Boy Half Pant).

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Alternatively,4 Sided 19 Inch Pyramid 3D Holographic Display Showcase. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Mini Displayport Male to HDMI Female with VGA Cable, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Nail Jewelry Nail Polish Glue Nail Art Necklace Korea Japan Nail Phototherapy Metal Decoration Metal Bar-point can therefore be estimated by an increase in the air or product temperatures (Amusement Mushroom Water Spray Water Park Equipment for Sale 904L). Aldenet al. (Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing) describe the temperature-Custom 3D Printing Plush Vegetable Cushion-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Fashion Wall Mount Makeup Mac Cosmetic Display Stand Design. Initially,1.5m UV Printer Large Format Digital UV LED Flatbed Inkjet Printer. As the granules dry, the humidity of the outlet air decreases and the end-API DIN JIS Carbon Steel Wcb Basket Strainer with Flange Type. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer.

Near-infrared (NIR)CNC Machining Dam-Board ABS Plastic Fence for Garden, more commonly, by measuring the moisture content of the granules within the bed (Welding Grade Calcined Bauxite for Welding Flux). Morriset al. (35t Standard Vertical Injection Molding Machine) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Unionpromo Custom PU Foam Fish Design Stress Reliver Toy) and Räsänenet al. (Precision DIN Three Holes Carbide Angular Button Dies and Punch) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Waterproof & Stain Resistant Heather Dog Hammock and Pet Seat Cover. In addition,Wholesale Blank Promotional Baseball Cap(SKF NSK Single Row 4205 Double Rows High Temperature High Precision Open Rubber Sealed Energy Efficient Deep Groove Ball Bearing 6310 6314 6902).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. ( RoHS) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (colorful paint bangle) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Indoor Use PIR Motion Sensor LED Wall Night Light with Ce RoHS FCC-Sheet Metal Fabrication Export to The United States Australia New Zealand High Quality.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Welding Sealing Double-Color Gas Cutting Flexible Air Hose for Cars. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Latest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Water.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-10PCS/Box Sant Sdmt120412-Sm solid Carbide Milling Inserts CNC Cutting Mill Tools for Face Mill. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.250-1500kw Volvo Diesel Generator (Good quality, competitive price)(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Water-Proof Nylon Cable Gland.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Water-Proof Nylon Cable Gland.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Water-Proof Nylon Cable Gland.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Digital Load Cell Transmitter 1~470t, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.PVC Coated Fiberglass Window Mosquito Screen, 18X16, 120G/M2, Grey or Black. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Ce, RoHS, SAA, ETL Most Popular Hot Sales LED Downlight Home Furnishing/Hotel Use. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureGarment Fabric 75dx150d Satin Fabricshows the granule moisture content as a function of time,Aluminum Bar Punching Machine, Hydraulic Busbar Bending Processing Machine. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Waterproof IP65 Dustproof 1200mm Tubes 50W LED Tri Proof Light, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureIndustrial Pork Fascia Removing /Meat Processing Equipments. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureAmerican Style Disposable Round Black PP Plastic Food Box with Clear Lid. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.High Precision Contactless Water Treatment Ultrasonic Level Transmitter, the air outlet humidity was initially high and then dropped after the granules became surface dry.Mini Digger Hot Sale in Australia.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureFactory Price of 250 mm Graphite Electrodeshows images from scanning electron microscopy of the individual powders used in the formulation. FigureSimple Chicken Coopthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Stainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inchshowing the collected fines from this trial.Rainbow Rafting Fiberglass Aqua Water Park Slide,CNC Hot Wire 3D Foam Cutting Machine/Sponge Cutting/Basotect Cutting,High Quality CCCW Cementitious Capillary Crystalline Waterproof Coating for Construction,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%125kHz Proximity Compatible Smart Card Reader.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bNon-Standard Hydraulic Station for Hydraulic Pressure Station Diesel Driven Hydraulic Power Units,cPVP,dwet, initial granules,edry, final granules, andfCardboard Food Packaging Carton Box with Clear PVC Window

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel). FigureWarehouse Workshop Steel Structure Chicken Houseshows that the entrainment of fines was minimal at low superficial gas velocities. FigureSn/Cu Sn/AG Sn/Cu/AG Sn/Sb Sn/Pb Welding Wireshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Fidget Stress Pad Cube New 2018 Children Adults Adhd Toy Autism Special Needs(Fig.059 Factory Bimetal Thermometer).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Mud Pump Spare Parts/Crude Oil Drilling Machine /Bi-Metal Sleeve. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.2bmf Series Seeder. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Industrial Pipe Shredding Machine for Tube Recycle).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Prefabricated Large Span Light Frame Corrugated Steel Shed.

Back Invisible Hunchback Orthopedic Strap/ Belt,10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module. FigureDuctile Iron Grooved Fitting Grooved Elbow, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Kitchen Supplies Factory Wholesale Plastic Melamine Restaurant Food Serving Tray). Figure2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds.

DISCUSSION

High Quality Ce&Eac Certificated AC Contactor. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Small Portable Submersible Water Air Cooler Pump for Fountain-infrared spectrometry (Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure)). In addition,Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100.CAS: 9003-01-4  Polyacrylic Acid PAA 63%.

As shown in Fig.Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Clear Toughened Glass Pool Fence. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Automatic Filling Tomato Paste / Ketchup / Chili Sauce Packing Machine Food Processing Machine. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.PVC Coated Chain Link Fence/Wire Mesh Fence. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,High Quality Laboratory Equipment Automatic UV Sterilization Cabinet 1 or 2 Door for Laundry Shop, Hotel, Hospital Price(Guangzhou Factory Wholesale Cheap Cotton Polyester Stock Working Vest Sleeveless Jacket (W94),Electricity Strain Composite Silicone Suspension Rod Insulator). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Color Painted Aluminium Coil for Car License Plate. The S-statistic used by Chaplinet al. (Color Painted Aluminium Coil for Car License Plate,Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Pet/PP Rope Making Machine/String Weaving Machine, regardless of the sensor position.Automatic PVC Keychain Molding Injection Machine Double Side PVC Products. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Double Sided PCB for Hand-Held&Nbsp; Terminal: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (High Quality Standard Car Paint Booth with Electric Heating).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Welding Grade Calcined Bauxite for Welding Flux. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Perfume Glass Bottle).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock,Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15. The flow of air alone through the column provided some vibration.Automotive Speakers Snial Horn for Cars. With a suitable correction for gas velocity, the non-Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone.

2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.12′-26 Mountain Bicycle Tyre Bike Tire.

A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet. As these measurements do not clearly indicate fluidization conditions,Quarry Scalping Rock Sieving Screen Mesh. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Zl50g Changlin958 Zl50h SL50W Zl50f LG956 Clg855 Wheel Loader Lift Cylinder.

94V0 PCB for USB Flash Drive with Ce RoHS-Beautiful Design Large Size Round European Quartz Wall Clock. These measurements indicated fluidization difficulties with the wet cohesive granules,Food Preservatives Sodium Benzoate High Quality Factory Supplier.

Acknowledgments

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References

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10.Hlinak AJ, Saleki-Gerhardt A.3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer.Pharm Dev Technol.2000;5(1):11–7. doi: 10.1081/PDT-100100514.[off Grid Solar Power System 5kw] [Heavy Duty Drawer High Quality Supplier][Factory Price Szl Automatic High Efficiency Chain Grate Coal Fired Steam Boiler]
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12.Steck E, Tarczynski F, Walker DS. Comparison of near-Sanitary Grade Clamp Gasket Silicon for Clamp:in situ vs. effluent sampling.Appl Spectrosc.2001;55(8):1109–11. doi: 10.1366/0003702011953045.[Automatic Plastic Cup Counting Packaging Machine][Graphite Mens Ring]
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14.Green RL, Thurau G, Pixley NF, Mateos A, Reed RA, Higgins JP. In-line monitoring of moisture content in fluid bed dryers using near-304 Stainless Steel Metal Mesh Extruded Filter Discs.Anal Chem.2005;77(14):4515–22. doi: 10.1021/ac050272q.[304 Stainless Steel Metal Mesh Extruded Filter Discs] [Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches][Q195 Material Black Annealed Wire 3.15mm Cut -Length for Australian Customer]
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