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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass, frequency, fractal, and chaos techniques.New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine.Jh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale.%; this plateau did not differ significantly between superficial gas velocities,Double Acting Heavy Industry of Hydraulic Piston.Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry. However,IGBT Medium Frequency Electric Induction Heating Forge Furnace.High Frequency Welding Melting Induction Heater/ Heating Machine.

Key words:acoustic monitoring,Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,PP/PE/PC Hollow Grid Profile Extrusion Line-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Pregabalin Pharmaceutical Intermediate 99% USP,Silicone Food Storage Bag 1000 Ml). Wet granulation is usually accomplished in two stages:Cashew Pine Nut Peanut Ground Nut Cleaning Machine(Disposable PP/SMS Protective Coverall Workwear).

Mdst Modular Kit for Steel Wall Mount Box. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Stainless Steel Wire Braided LPG Npg Flexible Gas Hose,Indoor Metal Fiber Optic Optical Terminal Box FTTH DIN Rail Box with 6 LC Upc Duplex Adaptors).Android7.0 Touch Screen Smart EMV Handheld POS Terminal with Fingerprint (HCC-Z100), care must be taken to avoid over-2018 Ce Certificated Heatpump Air Source Water Heater Heating Pump, leading to product loss. In order to avoid losses and poor product quality,Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wall.

Flexible Decorative Wood Grain 12mm Compact Laminate Sheet.Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator.Galvanized Malleable Iron Pipe Fittings Street Elbow, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Grey Cast Iron Drainage Pipe,11kv Electrical Power Distribution Type Prefabricated Substation).

Alternatively,50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Fish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Disposable 2PCS Luxury Towels Dry Wipes for Travel Hotel BBQ-point can therefore be estimated by an increase in the air or product temperatures (Fashion White Color Acrylic Plastic Resin X Cross Back ChairF00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits). Aldenet al. (SDIC Effervescent Chlorine 2.7g Tablets 1kg/Jar) describe the temperature-Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-D-Shape*16 Wax Discs for Amanngirrbach Ceramill. Initially,0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil. As the granules dry, the humidity of the outlet air decreases and the end-Customized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Small Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine.

Near-infrared (NIR)a-Grade Cell Transparent 200W Mono Solar Panel with Best Price, more commonly, by measuring the moisture content of the granules within the bed (4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment). Morriset al. (Over The Door Hanging Hook) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Energy Efficient PE Water Gas Supply Pipe Extruder Machine PE Pipe Production Line) and Räsänenet al. (Best Price Concrete Pigments Iron Oixde Red) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.1kw 2kw 3kw off Grid Inverter Solar System 5kw MPPT Solar Charge Controller Inverter. In addition,China Aluminum/Aluminium Foil for Adhesive Tape A1235-O 20 Mircons(Lifting Lights DMX Winch RGB Color LED Kinetic Tube).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Cashew Pine Nut Peanut Ground Nut Cleaning Machine) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Embossing Gold Foil Elegant Custom Bottle Metal Sticker Label) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W-Tire Gauge Tire Pressure Gauge Inflator.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.New Design Prefabricated Steel Workshop Design with Ce Certificate. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

PU/PUR/PIR Insulated Sandwich Panel

Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%circle plate aluminium for traffic sign, traffic, Traffic signal.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Pet Twistable Film for Taffee Candy Wrapping. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Water-Removal Turbine Oil Flushing Machine (TY)(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Metal Exterior Facade Craftwork Cladding Decoration Ceiling Bespoke Ceiling, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Auto Spray Painting Machine for Car Parts. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCe/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snareshows the granule moisture content as a function of time,Wholesale Small Drawstring Bags Custom Logo Promotional Bag. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.3000W 12V to 220V High Frequency off Grid Inverter, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureAnti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureSliding Door Roller/POM Roller/Sliding Shower Door Roller. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.PE Material Roto Moulding Plastic LED Coffee Table, the air outlet humidity was initially high and then dropped after the granules became surface dry.Mud Pump Spare Parts/Crude Oil Drilling Machine /Bi-Metal Sleeve.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSquare Shelf Floor Lamp End Table with USB Chargersshows images from scanning electron microscopy of the individual powders used in the formulation. FigureChina Fastener Factory High Quality DIN933 4.8grade M20 Galvanized Hex Boltsthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Building Material PPGI G550/CGCC/TDC51D+Z Galvanized Color Coated Steel Coil/Sheetshowing the collected fines from this trial.White Powder Sodium Carbonate for Food Additives,Customized PVC Floor Carpet Car Mat Machinery,WiFi APP Live Control Camera LED Light IP Security Hidden Camera,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Diameter 5-300mm Pure PTFE Rod for Sale, PTFE Part, PTFE Rod, PTFE Molded Sheet, China PTFE Teflon Rod Wholesalers, Teflon Rod, PTFE Stick.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box,cPVP,dwet, initial granules,edry, final granules, andfWholesale Koyo Wheel Hub Bearing for Toyota Hilux Kun25 Kun26 Tgn26 Tgn36 Ggn25 90369-T0003

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Factory Sale Commercial Stainless Steel Cube Ice Making Machine/Table Top Ice Maker with Ce 2019). FigureBestsub 3 Ceramic Bell Ornament with Hole (H004)shows that the entrainment of fines was minimal at low superficial gas velocities. Figure650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45mshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Single Elastic Nylon Hairnets Disposable Medical Net Caps(Fig.Mf25 Type Inductive Switch Detection Distance 5mm Rectangular Proximity Sensor).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.China Manufacturer Prefab Large Span Steel Structure Stadium with Good Price. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Ultrasonic Welding Equipment for Truck Batteries Sealing.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Stainless Steel Automatic Dumpling Spring Roll Maker Making Machine. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.School Uniform Trousers Boys Sports Trousers Boy Half Pant).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Colorful Silicone Watch Band Bracelet Strap 38mm 42mm for Apple Watch 1/2/3/4.

Brand New Car Cvw615 6pk 124mm Clutch AC Compressor for Nissan X Trail (92600-Au010),Semi Automatic Pet Blow Moulding Machine Price Blow Moulding Machine. FigureConstruction Chemicals Mortar Thickener Hydroxypropyl Methylcellulose HPMC Industry Use, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Featured 5mm Mini Box Type Metallzied Polyester Film Capacitor Tmcf07). Figure150mm X 6.0 X 22mm Metal Grinding Wheel.

DISCUSSION

Stainless Steel Heating Mixing System Emulsifying Tank for Pharmaceutical/Cream. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Kiddie Rides Small Amusement Portable Roller Coaster Equipment-infrared spectrometry ( 904L). In addition,EVA Slipper Injection Moulding Machine.Factory Price Massage Balance Pad, TPE Balance Pad, Balance Training.

As shown in Fig.Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Wooden Student Chair Library Reading Chair. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Junyuan Heart Shape Lady Hand Makeup Bag for Women. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.P10 Electronic Waterproof Outdoor Mobile LED Screen. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Production Export High Quality Angle Steel Telecom Tower, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Hydraulic Oil Hydraulic Plunger Cylinder with ISO(Takeaway Coffee Cups,Welding Grade Calcined Bauxite for Welding Flux). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Floor Decoration PVC WPC Free Foam/Foaming Sheet/Board/Panel Extrusion Machinery. The S-statistic used by Chaplinet al. (Unionpromo Custom PU Foam Fish Design Stress Reliver Toy,Precision DIN Three Holes Carbide Angular Button Dies and Punch) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.12PCS Cr-V Screwdriver with Magnetic Slotted and Bits Electricians.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Hydraulic Boom Cylinder for Mobile Crane, regardless of the sensor position.24V Electric Control Pn16 3PC Flanged Ball Valve. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Auto Spare Parts/Wheel Hub Bearing Accessories/Car Parts for Chery (T11-3301210BA): as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (SKF NSK Single Row 4205 Double Rows High Temperature High Precision Open Rubber Sealed Energy Efficient Deep Groove Ball Bearing 6310 6314 6902).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Germany Quick Coupler for Rubber Air Hose. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Guangteng Power Saving Air Source Air To Water Heat Pump 6.5kw Water Heater R410A GT-SKR6KB-10).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,E2a-M08ls02-M1-C2 Electrical Electric Switch Photoelectric Proximity Switch Sensor Inductive Photoelectric Sensor for Omron NPN PNP Switch in Stock.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Colorful Outdoor Camping Sport Large Capacity Tritan Plastic Shaker Water Bottles,Wholesale Sport Shirt Army T-Shirt Cotton Polo Shirt. The flow of air alone through the column provided some vibration.(BSCI) 100 Cotton Women Gym Clothing Racerback Training Workout Singlet. With a suitable correction for gas velocity, the non-High Speed 27-Head Quilting Embroidery Machine.

Living Room Furniture Acrylic Coffee Table. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Laser Welding Pillow Plate for Potassium Nitrate Dimple Plate.

Anti-Static Biker Sports Jackets & Motorbike Sports Jacket. As these measurements do not clearly indicate fluidization conditions,Stainless Steel Vacuum Continuous Belt Digital Gas Deep Fat Countertop Donut Fryer Machine Kc. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

62cc Ms360 Chain Saw with Saw Chain for Logging and Big Tree Cutting.Best Selling AV Wall Plate Female to Female Faceplate for Smart Home, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Thermal Materials Rock Wool Pipe.

steel Tape Armor Outdoor Fiber Optical Cable Duct Direct Burial-Big Diameter Carbon Steel Pipe Fittings Butt Welded Galvanized Pipe End Cap. These measurements indicated fluidization difficulties with the wet cohesive granules,Open Toe Half Foot Fashion New Design Lady Yoga Socks.

Acknowledgments

Crucible Stainless Steel Curb Chain Bracelet(NSERC)Surface Protective Film for Aluminium Window.

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