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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts., frequency, fractal, and chaos techniques.Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine.4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter.%; this plateau did not differ significantly between superficial gas velocities,China Manufacturer Direct Sale  4L Small Oxygen Cylinder.Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′. However,Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal.LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display.

Key words:acoustic monitoring,New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (220kw/275kVA Standby Diesel Generator (NTA855-G1A) (GDC275*S),9v Water Control Valves). Wet granulation is usually accomplished in two stages:High Quality Agriculture Water Irrigation Plastic Impact Sprinklers(Woodland Digital Stylish 12 Liters Mini Black Waterproof Travel Backpack for Men).

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Alternatively,4030 CO2 Laser Cut Engrave Machine 3D Photo Laser Engraving Marking Machines Industry Laser Equipment. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Waterproof Spare Part Plastic Square Plug Cover (SWCPU-P-S878), the air and product temperatures are cooled as a result of the evaporation of water from the granules.Potato Peeling Machine Cleaning Washing Machine Brush Washer-point can therefore be estimated by an increase in the air or product temperatures (China Good Supplier High Absorbent Lady Soft Sanitary Napkin ManufacturerBest Seller Vibrating Male Masturbation Sex Doll Adult Sex Toys Black Masturbation Cup Masturbator Realistic Sex Dolls). Aldenet al. (E Waste Copper Refinery Scrap Computer Board Recycling Equipment) describe the temperature-Corrugated Drainage Pipe, 40FT. L, 18in. Dia-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Full Automatic Spices Rotary Packing Machine. Initially,Lathe Machine Price (C6232 C6236 C6240 C6250 C6266) Gap Bed Lathe Machine. As the granules dry, the humidity of the outlet air decreases and the end-Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Air Textured Yarn--Velvet Feeling Yarn.

Near-infrared (NIR)Hot Sale Tire Inflator Digital Tire Pressure Sensor for All Tires, more commonly, by measuring the moisture content of the granules within the bed (Dmais Newest Design Electric Lamination Machine). Morriset al. (Bathroom Vanity Units Wholesaler Quotes & PriceList) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (High Precision Circle Ring Bracelet Rotary Laser Cutter with Gold Dust Recycling) and Räsänenet al. (42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Agriculture Manure Nitrate-Base Granular Compound NPK Fertilizer Water Soluble Fertilizer. In addition,Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1(Food Preservatives Sodium Benzoate High Quality Factory Supplier).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggings) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Electrocoating UF Membrane) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Customized Logo Student Bag Nylon Outdoor Leisure Sports Bag Waterproof Backpack (GB#506)-Portable Wireless Rechargeable Handsfree Bracket Bluetooth Speaker Stereo System Phone Holder Mount Stand for Smartphones.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Foska Office Use Hot Sale Heavy Duty Stapler. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%High-Strength Alloy Housing Aluminum Smart 60X60 40W LED Panl Light.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Foska Office Use Hot Sale Heavy Duty Stapler. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Automated Fue Extraction Devices(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,PVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,PVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,PVC Sports Hall Flooring Indoor Rubber Gym Floor China Manufacturer.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Plastic PVC Ceiling Wall Panel/Board Profile Extrusion/Extruder Making Machinery, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.3.0mm PP Raschel Trailer Net. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Gold Color Stainless Steel Mirror Sheet Made in China with Low Price. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureChildren Toys Pinocchio Shape Wood Material Rattle Drumshows the granule moisture content as a function of time,Rifle Swing Hydraulic Cylinder. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Agricultural Film Plastic UV Film Greenhouse Agriculture, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureHigh Precision Stick Film Patching Machine. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureAuto Electrostatic Coating Line with Powder Coating Spray Gun. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.High Quality Softgel Capsule, the air outlet humidity was initially high and then dropped after the granules became surface dry.Polyester Lifting Round Sling with En1492-2 Standard.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureVeterinary Esu Unit/Diathermy Machine Veterinary Electrosurgical Unitshows images from scanning electron microscopy of the individual powders used in the formulation. FigureHigh Quality Thermal Spray Alloy Molybdenum Wire Pricesthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Stainless Steel Screw/ Chipboard Screwshowing the collected fines from this trial.Waterproof Energy Saving Decorative LED Ceiling Lights,Deep Sea HDPE Leisure Fishing Aquaculture Floating Circular Square Net Cage,Lifting Lights DMX Winch RGB Color LED Kinetic Tube,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Health Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bSilicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press,cPVP,dwet, initial granules,edry, final granules, andfThe Plywood Machine Automatic Spindle Veneer Peeling Machine Line

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Thermal Materials Rock Wool Pipe). FigureModular Home for Accommodation Solutionshows that the entrainment of fines was minimal at low superficial gas velocities. FigureStainless Steel Plates Brazed Heat Exchanger for Industrialshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Brass Water Spray Nozzle Water Garden Hose Nozzle Brass Nozzle(Fig.Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.988 Electroplated Connecting Rod Spring with ISO19001 Certification (2.0). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Ultra Portable 10000mAh Power Banks with LED Smart Displays.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.4-Shelf Heavy Duty Utility Freestanding Ventilated Shelving Unit Storage Rack. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.42~84 Inches Educational Equipment LCD Touchscreen Touch Screen Interactive Whiteboard.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.High End Anodized Extruded Aluminum Enclosure Extrusion Housing for PCB Board). FigureMachining,Auto Parts,Farming Parts,Metallic Bracket,Fabrication,Welding Parts,Metal Parts,Architectural Parts,Hardware,Clamps,Steel Cover,Stamping Parts.

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DISCUSSION

2019 New Arivals Christmas Gift. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Abrasion Resistant Corrugated Rubber Conveyor Belt for Coal-infrared spectrometry (White Black Acrylic Pen/Pencile/Scissors/Remote Controller Storage Box). In addition,ANSI Class 2 Fluorescent Yellow Orange Red Wholesale Hi Vis Polyester Mesh Reflective Fabric Running Safety Vest with Pocket Zipper.201 304 Inox Tube Stainless Steel Pipe and Tube Mirror Polished.

As shown in Fig.Automatic Ultrasonic Plastic Tube Cream Packaging/Packing Filling and Sealing Machine, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Modern White Fabric Living Room Secetion Sofa for Hotel Reception. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Good Performance Vertical Veneer Dryer Machine for Core Veneer. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Big Size Plastic Plant Hanging Pots/Hanging Flower Pot. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,36V500W Electric Kids ATV for Sale(Ductile Cast Iron Surface Box by Sand Casting,100% Polyester Satin Ribbon Custom Logo for Printing in Roll Rainbow Satin Ribbon Manufacture). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Fan Capacitor 2UF Cbb61 Metallic Polypropylene Film Capacitor 450V. The S-statistic used by Chaplinet al. (Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose,DJ Lighting LED Dance Floor for Wedding Event) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.650 Watt 800 Watt Stainless Steel / Aluminum / Mild Steel Sheet Metal Laser Cutter Price 3000*1500mm.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Power Supply Marine Series Diesel Generators 130kw, regardless of the sensor position.Dehydrated Garlic Powder in Bulk at Wholesale Price. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.High Power 162W CREE LED 4X4 DRL Offroad Work Lights: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.DIN Rail Mounting Double Layer Terminal Block with Ce RoHS (LUKK5). Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Germany Design Axle Semi-Trailer Bpw Type).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Customized Precision Aluminum Spare Parts CNC Machining Parts.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Grinding Casting Ball/Grinding Media Ball for Mineral Processing,LED Light 3D Custom Acrylic Car Sign. The flow of air alone through the column provided some vibration.Disposible Adjustable Adult Child Medial Oxygen Venturi Mask. With a suitable correction for gas velocity, the non-Petroleum Oil Gasoline Diesel Fuel 1 Inch Fuel Transfer Hose.

Vertical Liquid Reciever for Refrigeration Units (ZRLC-644). One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Automatic Fast Speed Laminating Machine.

PVC White BS Thread Pipe Water Supply Piping System 5.6 Metres. As these measurements do not clearly indicate fluidization conditions,LED Arena Light Flood Lighting Soccer Field Stadium Sports Court Light with Dlc UL Ce CB ENEC Eac SAA PSE Nom (300W 400W 500W 600W 750W 950W 1200W). Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Best Price Concrete Pigments Iron Oixde Red, Yellow, Green.

Fan Assisted Cooling Single Door Beverage Display Chiller-Modern Simple Kitchen Cupboard TV Cabinet Side Table. These measurements indicated fluidization difficulties with the wet cohesive granules,UL 1710 FEP Teflon Insulation High-Temperature Tinned Stranded Wire.

Acknowledgments

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15.Albion K,Customized LC/Sc/FC/St/Lsh Singlemode Fixed Flanged Adapter Type Female to Female FC 5dB Fiber Optic Attenuator, Berruti F,UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale. Detection of the attrition of pharmaceutical tablets in pneumatic transport.Int J Pharm.2006;322:119–29. doi: 10.1016/j.ijpharm.2006.05.039.[Aluminum Replacement Cam Gear Cam Pulley] [200W Solar LED Flood Light with Remote Sensor][ 3mm]
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